Now showing items 1-7 of 7

    • Arc is a flexible modular protein capable of reversible self-oligomerization 

      Myrum, Craig; Baumann, Anne; Bustad, Helene J.; Flydal, Marte Innselset; Mariaule, Vincent; Alvira, Sara; Cuéllar, Jorge; Haavik, Jan; Soulé, Jonathan; Valpuesta, José María; Márquez, José Antonio; Martinez, Aurora; Bramham, Clive R. (Portland Press, 2015)
      The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ...
      Journal article
    • HAMLET forms annular oligomers when deposited with phoshpolipid monolayers 

      Baumann, Anne; Gjerde, Anja Underhaug; Ying, Ming; Svanborg, Catharina; Holmsen, Holm A.; Glomm, Wilhelm; Martinez, Aurora; Halskau, Øyvind (Elsevier, 2012-04)
      Recently, the anticancer activity of human α-lactalbumin made lethal to tumor cells (HAMLET) has been linked to its increased membrane affinity in vitro, at neutral pH, and ability to cause leakage relative to the ...
      Journal article
    • HAMLET interacts with lipid membranes and perturbs their structure and integrity 

      Mossberg, Ann-Kristin; Puchades, Maja; Halskau, Øyvind; Baumann, Anne; Lanekoff, Ingela; Chao, Yinxia; Martinez, Aurora; Svanborg, Catharina; Karlsson, Roger (Public Library of Science, 2010-01-23)
      Background Cell membrane interactions rely on lipid bilayer constituents and molecules inserted within the membrane, including specific receptors. HAMLET (human α-lactalbumin made lethal to tumor cells) is a tumoricidal ...
      Peer reviewedJournal article
    • Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line 

      Raasakka, Arne; Ruskamo, Salla; Kowal, Julia; Barker, Robert; Baumann, Anne; Martel, Anne; Tuusa, Jussi; Myllykoski, Matti; Bürck, Jochen; Ulrich, Anne S.; Stahlberg, Henning; Kursula, Petri (Nature Publishing Group, 2017-07-10)
      Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm compartment between two cytoplasmic leaflets ...
      Journal article
    • The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes 

      Skjevik, Åge Aleksander; Mileni, Mauro; Baumann, Anne; Halskau, Øyvind; Teigen, Knut; Raymond C., Stevens; Martinez, Aurora (Elsevier, 2014-01-09)
      Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of catecholamine neurotransmitters, and a reduction in TH activity is associated with several neurological diseases. Human TH is regulated, among ...
      Journal article
    • The Peripheral Binding of 14-3-3γ to Membranes Involves Isoform-Specific Histidine Residues 

      Bustad, Helene J.; Skjærven, Lars; Ying, Ming; Halskau, Øyvind; Baumann, Anne; Rodriguez-Larrea, David; Costas, Miguel; Underhaug, Jarl; Sanchez-Ruiz, Jose M.; Martinez, Aurora (Public Library of Science, 2012-11-26)
      Mammalian 14-3-3 protein scaffolds include seven conserved isoforms that bind numerous phosphorylated protein partners and regulate many cellular processes. Some 14-3-3-isoforms, notably γ, have elevated affinity for ...
      Peer reviewedJournal article
    • Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme 

      Bezem, Maria Teresa; Baumann, Anne; Skjærven, Lars; Meyer, Romain; Kursula, Petri; Martinez, Aurora; Flydal, Marte Innselset (Nature Publishing Group, 2016-07-27)
      Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. TH is a highly complex enzyme at mechanistic, structural, and regulatory levels, and the preparation of ...
      Journal article