• Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis 

      Gucek, Alenka; Gandasi, Nikhil R.; Omar-Hmeadi, Muhmmad; Bakke, Marit; Doskeland, Stein Ove; Tengholm, Anders; Barg, Sebastian (Peer reviewed; Journal article, 2019-05-20)
      Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the extracellular space, through which small transmitter molecules such as ATP can exit. Co-release of polypeptides and hormones like ...
    • Increased microvascular permeability in mice lacking Epac1 (Rapgef3) 

      Kopperud, Reidun Kristin; Rygh, Cecilie Brekke; Karlsen, Tine Veronica; Krakstad, Camilla; Kleppe, Rune; Høivik, Erling Andre; Bakke, Marit; Tenstad, Olav; Selheim, Frode; Liden, Åsa; Madsen, Lise; Pavlin, Tina; Taxt, Torfinn; Kristiansen, K.; Curry, FE; Reed, Rolf K.; Doskeland, Stein Ove (Peer reviewed; Journal article, 2017-02)
      Aim: Maintenance of the blood and extracellular volume requires tight control of endothelial macromolecule permeability, which is regulated by cAMP signalling. This study probes the role of the cAMP mediators rap guanine ...
    • Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling 

      Edland, Fridtjov; Wergeland, Anita; Kopperud, Reidun Kristin; Åsrud, Kathrine Sivertsen; Hoivik, Erling A; Witsø, Solveig Lund; Æsøy, Reidun; Madsen, L; Kristiansen, K.; Bakke, Marit; Doskeland, Stein Ove; Jonassen, Anne K (Peer reviewed; Journal article, 2016-11-28)
      Background: Obesity is still considered a risk factor for cardiovascular disease, although more recent knowledge also suggests obesity to be associated with reduced morbidity and mortality - the “obesity paradox”. This ...
    • Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy 

      Åsrud, Kathrine Sivertsen; Pedersen, Line; Æsøy, Reidun; Muwonge, Haruna; Aasebø, Elise; Pettersen, Ina Katrine Nitschke; Herfindal, Lars; Dobie, Ross; Jenkins, Stephen; Berge, Rolf Kristian; Henderson, Neil Cowan; Selheim, Frode; Doskeland, Stein Ove; Bakke, Marit (Peer reviewed; Journal article, 2019-09-24)
      The exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) are expressed in a cell specific manner in the liver, but their biological functions in this tissue are poorly understood. The current study was ...
    • New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells 

      Viktorsson, Elvar Örn; Aesoy, Reidun; Støa, Sindre; Lekve, Viola; Doskeland, Stein Ove; Herfindal, Lars; Rongved, Pål (Journal article, 2021)
      Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (3) and myxin (4) exhibit potent and ...