Now showing items 1-10 of 13

    • Activated NK cells are potent effectors against glioblastoma cells due to activating KIR2DS2 and KIR2DS4 - HLA ligand interactions - In vitro study 

      Gras Navarro, Andrea (The University of Bergen, 2013-06-03)
      Background: Glioblastoma (GBM) is the most malignant brain tumor, where patients' median survival is only 14,6 months after diagnosis, thus novel, effective adjuvant therapies are required. Natural Killer (NK) cells ...
      Master thesis
    • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

      Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Springer, 2015-01)
      Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
      Journal article
    • Cancer stem cells as mediators of treatment resistance in brain tumors: Status and controversies 

      Sakariassen, Per Øystein; Immervoll, Heike; Chekenya, Martha (Elsevier, 2007-11)
      Malignant primary brain tumors are characterized by a short median survival and an almost 100% tumorrelated mortality. Despite the addition of new chemotherapy regimes, the overall survival has improved marginally, and ...
      Journal article
    • A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma 

      Yang, Ning; Yan, Tao; Zhu, Huaiyang; Liang, Xiao; Leiss, Lina; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Huang, Bin; Costea, Daniela Elena; Enger, Per Øyvind; Li, Xingang; Wang, Jian (BioMed Central, 2014-10-04)
      Background: Although several studies suggest that stromal fibroblasts mediate treatment resistance in several cancer types, little is known about how tumor-associated astrocytes modulate the treatment response in brain ...
      Journal article
    • Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models 

      Netland, I. A; Førde, H. E; Sleire, L.; Leiss, L.; Rahman, M. A; Skeie, B. S; Gjerde, C. H; Enger, P. Ø; Goplen, D. (BioMed Central, 2016-08-19)
      Background: Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target ...
      Journal article
    • Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma 

      Svendsen, Agnete; Verhoeff, Joost J. C.; Immervoll, Heike; Brøgger, Jan C.; Kmiecik, Justyna; Poli, Aurélie; Netland, Inger A.; Planagumà, Jesús; Torsvik, Anja; Sakariassen, Per Øystein; Bjerkvig, Rolf; Enger, Per Øyvind; Tronstad, Karl Johan (Springer, 2011-08-24)
      Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer ...
      Peer reviewedJournal article
    • Increased infiltration and tolerised antigen-specific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients 

      Bahador, Marzieh; Gras Navarro, Andrea; Rahman, Mohummad Aminur; Dominguez Valentin, Mev; Sarowar, Shahin; Ulvestad, Elling; Njølstad, Gro; Lie, Stein Atle; Kristoffersen, Einar Klæboe; Bratland, Eirik; Enger, Martha Chekenya (Taylor & Francis, 2017)
      Human cytomegalovirus (HCMV) antigens in glioblastoma (GBM) present opportunities for personalised immunotherapy. However, their presence in GBM tissue is still under debate, and evidence of their impact on functional ...
      Journal article
    • A novel GFP nude rat model to investigate tumor-stroma interactions 

      Yang, Ning; Huang, Bin; Tsinkalovsky, Oleg; Brekkå, Narve; Zhu, Huaiyang; Leiss, Lina; Enger, Per Øyvind; Li, Xingang; Wang, Jian (BioMed Central, 2014-12-21)
      Backgroud: A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing a ...
      Journal article
    • Role of Caveolin-1 in Hypoxia and Proneural to Mesenchymal Transition of Glioblastoma 

      Kundu, Somdutta (The University of Bergen, 2018-06-29)
      Glioblastomas (GBM), a grade IV astrocytoma, is the most common and aggressive primary brain tumors in adults, associated with short survival and uniformly fatal outcome irrespective of treatment. GBM is highly heterogeneous ...
      Master thesis
    • Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival 

      Poli, Aurélie; Wang, Jian; Domingues, Olivia; Planagumà, Jesús; Yan, Tao; Rygh, Cecilie Brekke; Skaftnesmo, Kai Ove; Thorsen, Frits Alan; McCormack, Emmet; Hentges, François; Pedersen, Paal-Henning; Zimmer, Jacques; Enger, Per Øyvind; Chekenya, Martha (Impact Journals, 2013-09-09)
      Glioblastoma (GBM) is the most malignant brain tumor where patients’ survival is only 14.6 months, despite multimodal therapy with debulking surgery, concurrent chemotherapy and radiotherapy. There is an urgent, unmet ...
      Journal article