• Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma 

      Hossain, Jubayer; Latif, Md Abdul; Ystaas, Lars Andreas Rømo; Ninzima, Sandra; Riecken, Kristoffer; Muller, Arnaud; Azuaje, Fransisco; Vareecal Joseph, Justin; Talasila, Krishna Mukharji; Ghimire, Jiwan; Fehse, Boris; Bjerkvig, Rolf; Miletic, Hrvoje (Peer reviewed; Journal article, 2019)
      Background: Suicide gene therapy for malignant gliomas has shown encouraging results in the latest clinical trials. However, prodrug application was most often restricted to short-term treatment (14 days), especially when ...
    • Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts 

      Leiss, Lina Wik; Mutlu, Ercan; Øyan, Anne Margrete; Yan, Tao; Tsinkalovsky, Oleg; Sleire, Linda; Petersen, Kjell; Rahman, Mohummad Aminur; Johannessen, Mireille Kayitesi; Mitra, Siddharta S.; Jacobsen, Hege; Talasila, Krishna Mukharji; Miletic, Hrvoje; Jonassen, Inge; Li, Xingang; Brons, Nicolas H.C.; Kalland, Karl-Henning; Wang, Jian; Enger, Per Øyvind (Peer reviewed; Journal article, 2017-02-07)
      Background: Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers. Methods: We isolated stromal cells from patient-derived ...