Department of Clinical Medicine
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Bowel function and quality of life after superior mesenteric nerve plexus transection in right colectomy with D3 extended mesenterectomy
(Springer, 2016)Background: The aim of this study was to ascertain the impact of injury to the superior mesenteric nerve plexus caused by right colectomy with D3 extended mesenterectomy as performed in the prospective multicenter trial: ...Journal article -
Evaluation of a guided self-help intervention for irritable bowel syndrome - An interdisciplinary approach
(The University of Bergen, 2017-12-16)Background: Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder, defined by recurrent abdominal pain or discomfort, associated with defecation and/or altered bowel habits. Due to the lack ...Master thesis -
Randomized Controlled Trial of Extended Perioperative Counseling in Enhanced Recovery After Colorectal Surgery
(Wolters Kluwer, 2018-06)BACKGROUND: Enhanced recovery after surgery programs reduce the length of hospital stay in patients who undergo elective colorectal resection, but the reasons for this reduction are not well understood. OBJECTIVE: The aim ...Journal article -
Epidemiology of benign external hydrocephalus in Norway - a population-based study
(Elsevier, 2017-08)Background: Benign external hydrocephalus is defined as a rapidly increasing head circumference (occipitofrontal circumference) with characteristic radiological findings of increased subarachnoid cerebrospinal fluid spaces ...Journal article -
C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease
(PLOS, 2017-07-31)The pan lymphocyte marker CD45 exists in various isoforms arising from alternative splicing of the exons 4, 5 and 6. While naïve T cells express CD45RA translated from an mRNA containing exon 4, exons 4–6 are spliced out ...Journal article -
Type 2 diabetes genes : present status and data from Norwegian studies
(Norsk forening for epidemiologi, 2013)The worldwide rise in prevalence of type 2 diabetes has led to an intense search for the genetic risk factors of this disease. In type 2 diabetes and other complex disorders, multiple genetic and environmental factors, as ...Journal article -
The mediating effect of body mass index on the relationship between smoking and hip or knee replacement due to primary osteoarthritis. A population-based cohort study (the HUNT study)
(PLOS, 2017-12-28)To investigate the total effect of smoking on total hip or knee replacement (THR/TKR) due to primary osteoarthritis (OA) and to quantify the indirect effect of smoking through body mass index (BMI). Participants from the ...Journal article -
The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study
(Elsevier, 2017-06)Objective: Smoking has been associated with a reduced risk of hip and knee osteoarthritis (OA) and subsequent joint replacement. The aim of the present study was to assess whether the observed association is likely to be ...Journal article -
Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study)
(BioMed Central, 2017-05-18)Background: To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis. Methods: In a prospective cohort study, data from the second and third survey of the ...Journal article -
The Pharmacogenomics of Bipolar Disorder study (PGBD): Identification of genes for lithium response in a prospective sample
(BioMed Central, 2016-05-05)Background: Bipolar disorder is a serious and common psychiatric disorder characterized by manic and depressive mood switches and a relapsing and remitting course. The cornerstone of clinical management is stabilization ...Journal article -
Negotiating the boundaries of psychosis: A qualitative studyof the service provider perspective on treatment delay incommunity mental health
(Wiley, 2017)Aim: Evidence shows that many patients are detected and treated late in their course of illness, and that substantial delay occurs even after entry to mental health services. Although several studies have examined the ...Journal article -
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
(Nature Publishing Group, 2017)A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple ...Journal article -
Patient and surgical factors affecting procedure duration and revision risk due to deep infection in primary total knee arthroplasty
(BioMed Central, 2017-12-21)Background: The aim of this study was to assess which patient and procedure factors affected both the risk of infection as well as procedure duration. Additionally, to assess if procedure duration affected the revision ...Journal article -
Antibiotic treatment In patients with chronic low back pain and Modic changes (the AIM study): study protocol for a randomised controlled trial
(BioMed Central, 2017-12-15)Background: A previous randomised controlled trial (RCT) of patients with chronic low back pain (LBP) and vertebral bone marrow (Modic) changes (MCs) on magnetic resonance imaging (MRI), reported that a 3-month, high-dose ...Journal article -
Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy
(BioMed Central, 2017-08-14)Background: The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with ...Journal article -
Young people with epilepsy have an increased risk of eating disorder and poor quality diet
(Wiley, 2018-03)Objective: To investigate whether adolescents with epilepsy are at increased risk of having self‐reported eating disorder symptoms and poor quality diet compared to young people from the general population. Methods: We ...Journal article -
Selective intrathecal enrichment of G1m1-positive B cells in multiple sclerosis
(Wiley, 2017-10)Immunoglobulin gamma (IgG) heavy chain genes are associated with susceptibility to multiple sclerosis (MS) and IgG levels in the cerebrospinal fluid (CSF). However, how these variants are implicated in disease mechanisms ...Journal article -
The biology of aging and cancer: A brief overview of shared and divergent molecular hallmarks
(Buck Institute for Age Research, 2017-10)Aging is the inevitable time-dependent decline in physiological organ function and is a major risk factor for cancer development. Due to advances in health care, hygiene control and food availability, life expectancy is ...Journal article -
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
(Nature Publishing Group, 2017-05-17)The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ...Journal article -
Study-protocol for a randomized controlled trial comparing clinical and radiological results after three different posterior decompression techniques for lumbar spinal stenosis: the Spinal Stenosis Trial (SST) (part of the NORDSTEN Study)
(BioMed Central, 2017-03-21)Background: There are several posterior decompression techniques for lumbar spinal stenosis (LSS). There is a trend towards performing less invasive surgical procedures, but no multicentre randomized controlled trials have ...Journal article
