Blar i Department of Clinical Medicine på utgivelsesdato
Viser treff 41-60 av 2064
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Fabry disease model in Zebrafish : Studying molecular mechanisms of Fabry nephropathy in a Gb3-free environment
(Doctoral thesis, 2023-03-21)Bakgrunn: Fabry sykdom (FS) er en X-bundet lysosomal avleiringssykdom betinget i mutasjon i alfa-galactosidase genet (GLA). Enzymet alfa-galactosidase A (α-GAL) er ansvarlig for nedbryting av fettstoffet globotriaocylceramid ... -
Carboxyl ester lipase in pancreatic disease : In vitro and in vivo studies of human pathogenic CEL mutations
(Doctoral thesis, 2023-03-21)Karboksylester-lipase (CEL) er et fordøyelsesenzym som hovedsakelig er uttrykt i bukspytt-kjertelen. Det siste eksonet i CEL-genet inneholder et variabelt antall tandem repetisjoner (VNTR), altså en region av repeterte ... -
From archival tissues to systems biology: Using transcriptomics to investigate the progression of kidney disease
(Doctoral thesis, 2023-03-13)Innledning: Både nyrecellekarsinom og Fabrys sykdom påvirker nyrene på en progressiv måte. Gjennom bruk av RNA-sekvenserings teknologi kan man predikere og øke forståelsen av de ulike mekanismene som driver denne ... -
Radiographic markers of hip dysplasia in young adults: predictive effect of factors in early life
(Journal article; Peer reviewed, 2023-02-11)Background and objectives: Acetabular dysplasia in young adults occurs, despite screening for developmental hip dysplasia (DDH) in the neonatal period. We aimed to examine how early life factors predict radiographic ... -
Biomarkers and risk factors of neurodegeneration in multiple sclerosis
(Doctoral thesis, 2023-02-10)Bakgrunn og mål: Markører på nevrodegenerasjon er tett knyttet til klinisk funksjonsnedsettelse og sykdomsprogresjon hos pasienter med multippel sklerose (MS). Slike biomarkører kan derfor bidra til å identifisere potensielle ... -
Vitamin D, Calcium and Energy intake and the association with bone mineral density among elite level para cyclists and able bodied cyclists
(Master thesis, 2023-01-03)Background: Dietary intakes and supplement use among Paralympic Athletes are generally unknown, and expert advice is scarce. Low bone mineral density (BMD) is an issue many para athletes (PA) meet. Elite cyclists are ... -
Implementing screening for myocardial injury in non-cardiac surgery: perspectives of an ad-hoc interdisciplinary expert group
(Journal article; Peer reviewed, 2023)Objectives. Perioperative myocardial injury (PMI) is increasingly recognised as an important complication of non-cardiac surgery, with often clinically silent presentation, but detrimental prognosis. Active screening for ... -
Histopathological Growth Pattern in Colorectal Liver Metastasis and The Tumor Immune Microenvironment
(Journal article; Peer reviewed, 2023)Almost half of all patients with colorectal cancer present with or eventually develop metastasis, most frequently in the liver. Understanding the histopathological growth patterns and tumor immune microenvironment of ... -
Effects of insufficient sleep on sensorimotor processing in migraine. A randomised, blinded crossover study of event related beta oscillations
(Journal article; Peer reviewed, 2023)Background Migraine has a largely unexplained connection with sleep and is possibly related to a dysfunction of thalamocortical systems and cortical inhibition. In this study we investigate the effect of insufficient sleep ... -
Risk of total hip arthroplasty after elite sport: linking 3304 former world-class athletes with the Norwegian Arthroplasty Register
(Journal article; Peer reviewed, 2023)Objectives: At present, there is no cure for osteoarthritis (OA), but severe hip joint degeneration can require total hip arthroplasty (THA). The literature on OA after elite sport is limited. We hypothesise that elite ... -
Cancer related mortality in multiple sclerosis. A population based cohort study
(Journal article; Peer reviewed, 2023)Background: Cancer is a major cause of death, but how cancer influences mortality risk in Multiple Sclerosis (MS) is unclear. Objectives: Determine all-cause mortality and mortality following a cancer diagnosis among ... -
A Randomised Placebo-Controlled Study of Purified Anthocyanins on Cognition in Individuals at Increased Risk for Dementia
(Journal article; Peer reviewed, 2023)Importance Identifying nutritional compounds which can reduce cognitive decline in older people is a hugely important topic. Objective To study the safety and effect of anthocyanins in maintaining cognitive functioning ... -
What do bereaved relatives of cancer patients dying in hospital want to tell us? Analysis of free-text comments from the International Care of the Dying Evaluation (i-CODE) survey: a mixed methods approach
(Journal article; Peer reviewed, 2023)Purpose We conducted an international survey of bereaved relatives of cancer patients dying in hospitals in seven countries, with the aim to assess and improve the quality of care. The survey used the i-CODE (International ... -
Musculoskeletal pain patterns and association between dizziness symptoms and pain in patients with long term dizziness – a cross-sectional study
(Journal article; Peer reviewed, 2023)Background The impact of long-term dizziness is considerable both on the personal level and in society and may lead to self-imposed restrictions in daily activities and social relations due to fear of triggering the ... -
Dietary fish intake increased the concentration of soluble ACE2 in rats: can fish consumption reduce the risk of COVID-19 infection through interception of SARS-CoV-2 by soluble ACE2?
(Journal article; Peer reviewed, 2023)The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the cells after binding to the membrane-bound receptor angiotensin-converting enzyme 2 (ACE2), but this may be prevented through interception by soluble ... -
Paediatric Ureteroscopy (P-URS) reporting checklist: a new tool to aid studies report the essential items on paediatric ureteroscopy for stone disease
(Journal article, 2023)The burden of urolithiasis in children is increasing and this is mirrored by the number of surgical interventions in the form of ureteroscopy (URS). There exist many challenges in performing this surgery for this special ... -
Embryonic Stem Cells Can Generate Oral Epithelia under Matrix Instruction
(Journal article; Peer reviewed, 2023)We aimed to investigate whether molecular clues from the extracellular matrix (ECM) can induce oral epithelial differentiation of pluripotent stem cells. Mouse embryonic stem cells (ESC) of the feeder-independent cell line ... -
Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson's disease
(Journal article; Peer reviewed, 2023)Aberrant proteostasis is thought to be implicated in Parkinson’s disease (PD), but patient-derived evidence is scant. We hypothesized that impaired proteostasis is reflected as altered transcriptome-proteome correlation ... -
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis
(Journal article; Peer reviewed, 2023)Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. The aim of this study is to identify functional genes and ... -
The Clinical Frailty Scale for mortality prediction of old acutely admitted intensive care patients: a meta-analysis of individual patient-level data
(Journal article; Peer reviewed, 2023)Background This large-scale analysis pools individual data about the Clinical Frailty Scale (CFS) to predict outcome in the intensive care unit (ICU). Methods A systematic search identified all clinical trials that ...