Blar i Department of Clinical Medicine på forfatter "Appel, Silke"
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The Bacterial Preparation OK432 Induces IL-12p70 Secretion in Human Dendritic Cells in a TLR3 Dependent Manner
Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2012-02-21)Dendritic cells (DC) used in therapeutic cancer immunotherapy have to be able to stimulate T cells resulting in an immune response that can efficiently target the cancer cells. One of the critical hurdles has been the lack ... -
Expression of ESE-3 Isoforms in Immunogenic and Tolerogenic Human Monocyte-Derived Dendritic Cells
Sprater, Florian; Hovden, Arnt-Ove; Appel, Silke (Peer reviewed; Journal article, 2012-11-19)Dendritic cells (DC) are the only hematopoietic cells expressing the epithelial specific Ets transcription factor ESE-3. Here we analyzed presence and quantity of isoforms ESE-3a, ESE-3b and ESE-3j in various immunogenic ... -
Inflammatory Stratification in Primary Sjögren’s Syndrome Reveals Novel Immune Cell Alterations in Patients’ Minor Salivary Glands
Bharaj, Tamandeep Kaur; Aqrawi, Lara A.; Fromreide, Siren; Jonsson, Roland; Brun, Johan G.; Appel, Silke; Skarstein, Kathrine (Journal article; Peer reviewed, 2021)There is a critical need to deconvolute the heterogeneity displayed by the minor salivary glands of primary Sjögren’s syndrome (pSS) patients. This is challenging primarily because the disease etiology remains unknown. The ... -
Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses
Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Aarstad, Hans Jørgen; Appel, Silke (Peer reviewed; Journal article, 2011-01-05)Background: Design of tumour specific immunotherapies using the patients’ own dendritic cells (DC) is a fast advancing scientific field. The functional qualities of the DC generated in vitro are critical, and today’s gold ...