• Adding stress biomarkers to high-sensitivity cardiac troponin for rapid non-ST-elevation myocardial infarction rule-out protocols 

      Restan, Ingar Ziad; Sanchez, Ana Yufera; Steiro, Ole-Thomas; Lopez-Ayala, Pedro; Tjora, Hilde Lunde; Langørgen, Jørund; Omland, Torbjørn; Boeddinghaus, Jasper; Nestelberger, Thomas; Koechlin, Luca; Collinson, Paul; Bjørneklett, Rune Oskar; Vikenes, Kjell; Strand, Heidi; Skadberg, Øyvind; Mjelva, Øistein; Larsen, Alf Inge; Vernon, Bonarjee; Mueller, Christian; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2022)
      Aims This study tested the hypothesis that combining stress-induced biomarkers (copeptin or glucose) with high-sensitivity cardiac troponin (hs-cTn) increases diagnostic accuracy for non-ST-elevation myocardial infarction ...
    • The changing spectrum of microbial aetiology of respiratory tract infections in hospitalized patients before and during the COVID-19 pandemic 

      Serigstad, Sondre; Markussen, Dagfinn Lunde; Ritz, Christian; Ebbesen, Marit Helen; Knoop, Siri Tandberg; Kommedal, Øyvind; Heggelund, Lars; Ulvestad, Elling; Bjørneklett, Rune Oskar; Grewal, Harleen (Journal article; Peer reviewed, 2022-09-30)
      Background: The COVID-19 pandemic was met with strict containment measures. We hypothesized that societal infection control measures would impact the number of hospital admissions for respiratory tract infections, as well ...
    • Diagnostic Performance of Novel Troponin Algorithms for the Rule-Out of Non-ST-Elevation Acute Coronary Syndrome 

      Tjora, Hilde Lunde; Steiro, Ole-Thomas; Langørgen, Jørund; Bjørneklett, Rune Oskar; Skadberg, Øyvind; Bonarjee, Vernon V S; Mjelva, Øistein; Collinson, Paul; Omland, Torbjørn; Vikenes, Kjell; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2022)
      Background The European Society of Cardiology (ESC) rule-out algorithms use cutoffs optimized for exclusion of non-ST elevation myocardial infarction (NSTEMI). We investigated these and several novel algorithms for the ...
    • Diagnostic utility of oropharyngeal swabs as an alternative to lower respiratory tract samples for PCR-based syndromic testing in patients with community-acquired pneumonia 

      Serigstad, Sondre; Knoop, Siri Tandberg; Markussen, Dagfinn Lunde; Ulvestad, Elling; Bjørneklett, Rune Oskar; Ebbesen, Marit Helen; Kommedal, Øyvind; Grewal, Harleen (Journal article; Peer reviewed, 2023)
      Syndromic PCR-based analysis of lower respiratory tract (LRT) samples in patients with community-acquired pneumonia (CAP) improves the bacterial yield and time-to-results compared to culture-based methods. However, obtaining ...
    • Implementing a new emergency medical triage tool in one health region in Norway: some lessons learned 

      Brevik, Heidi Synnøve; Hufthammer, Karl Ove; Hernes, Merete Eide; Bjørneklett, Rune Oskar; Brattebø, Guttorm (Journal article; Peer reviewed, 2022)
      Background: Acutely sick or injured patients depend on ambulance and emergency department personnel performing an accurate initial assessment and prioritisation (triage) to effectively identify patients in need of immediate ...
    • Long-term follow-up of IgA nephropathy: clinicopathological features and predictors of outcomes 

      Haaskjold, Yngvar Lunde; Lura, Njål; Bjørneklett, Rune Oskar; Bostad, Lars Sigurd; Knoop, Thomas; Bostad, Leif Henry (Journal article; Peer reviewed, 2023)
      Background: The establishment of the Oxford classification and newly developed prediction models have improved the prognostic information for immunoglobulin A nephropathy (IgAN). Considering new treatment options, optimizing ...
    • Rapid syndromic PCR testing in patients with respiratory tract infections reduces time to results and improves microbial yield 

      Serigstad, Sondre; Grewal, Harleen; Ebbesen, Marit Helen; Kommedal, Øyvind; Heggelund, Lars; van Werkhoven, Werkhoven; Faurholt-Jepsen, Daniel; Clark, T.W.; Ritz, Christian; Ulvestad, Elling; Bjørneklett, Rune Oskar; Knoop, Siri Tandberg; Ravn, P.; Markussen, Dagfinn Lunde (Journal article; Peer reviewed, 2022)
      Lack of rapid and comprehensive microbiological diagnosis in patients with community acquired pneumonia (CAP) hampers appropriate antimicrobial therapy. This study evaluates the real-world performance of the BioFire FilmArray ...
    • Utilizing the MEST score for prognostic staging in IgA nephropathy 

      Haaskjold, Yngvar Lunde; Bjørneklett, Rune Oskar; Bostad, Leif; Bostad, Lars Sigurd; Lura, Njål Gjærde; Knoop, Thomas (Journal article; Peer reviewed, 2022)
      Background The Oxford classification/MEST score is an established histopathologic scoring system for patients with IgA nephropathy (IgAN). The objective of this study was to derive a prognostic model for IgAN based on the ...
    • Validation of two IgA nephropathy risk-prediction tools using a cohort with a long follow-up 

      Haaskjold, Yngvar Lunde; Lura, Njål Gjærde; Bjørneklett, Rune Oskar; Bostad, Leif; Bostad, Lars Sigurd; Knoop, Thomas (Journal article; Peer reviewed, 2022)
      Background: Recently, two immunoglobulin A (IgA) nephropathy-prediction tools were developed that combine clinical and histopathologic parameters. The International IgAN Prediction Tool predicts the risk for 50% declines ...