Blar i Department of Clinical Medicine på forfatter "Johannessen, Anne Christine"
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Analysis of salivary mycobiome in a cohort of oral squamous cell carcinoma patients from Sudan identifies higher salivary carriage of malassezia as an independent and favorable predictor of overall survival
Mohamed, Nazar; Litlekalsøy, Jorunn; Ahmed, Israa Abdul Rhman; Martinsen, Einar Marius Hjellestad; Furriol, Jessica; Javier-Lopez, Ruben; Elsheikh, Mariam; Mohamed, Nuha Mohamed Gaafar; Morgado, Luis; Mundra, Sunil; Johannessen, Anne Christine; Osman, Tarig Al-Hadi; Nginamau, Elisabeth Sivy; Suleiman, Ahmed; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-10-12)Background: Microbial dysbiosis and microbiome-induced inflammation have emerged as important factors in oral squamous cell carcinoma (OSCC) tumorigenesis during the last two decades. However, the “rare biosphere” of the ... -
Characterization of immune cell infiltrate in tumor stroma and epithelial compartments in oral squamous cell carcinomas of Sudanese patients
Mohamed, Nuha Mohamed Gaafar; Osman, Tarig Al-Hadi; Ahmed, Israa A.H.; Elsheikh, Mariam; Dongre, Harsh Nitin; Jacobsen, Martha Rolland; Mohamed, Nazar; Fromreide, Siren; Suleiman, Ahmed Mohamed; Johannessen, Anne Christine; Nginamau, Elisabeth Sivy; Costea, Daniela Elena (Journal article; Peer reviewed, 2021)Background Tumor immune infiltrate has been explored in oral squamous cell carcinoma (OSCC), but studies on simultaneous characterization of multiple immune cell subtypes separately in stromal and intraepithelial tumor ... -
Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan
Suliman, Nada M.; Åstrøm, Anne Nordrehaug; Ali, Raouf Wahab; Salman, Hussein; Johannessen, Anne Christine (Peer reviewed; Journal article, 2013-11-21)Background: Pemphigus is a rare group of life-threatening mucocutaneous autoimmune blistering diseases. Frequently, oral lesions precede the cutaneous ones. This study aimed to describe clinical and histological features ... -
Combined in situ hybridization and immunohistochemistry on archival tissues reveals stromal microRNA-204 as prognostic biomarker for oral squamous cell carcinoma
Rajthala, Saroj; Dongre, Harsh; Parajuli, Himalaya; Min, Anjie; Nginamau, Elisabeth Sivy; Kvalheim, Arild; Lybak, Stein; Sapkota, Dipak; Johannessen, Anne Christine; Costea, Daniela Elena (Journal article; Peer reviewed, 2021)Micro-RNAs (miRs) are emerging as important players in carcinogenesis. Their stromal expression has been less investigated in part due to lack of methods to accurately differentiate between tumor compartments. This study ... -
Embryonic Stem Cells Can Generate Oral Epithelia under Matrix Instruction
Das, Ridhima; Harper, Lisa; Kitajima, Kayoko; Osman, Tarig Al-Hadi; Cimpan, Mihaela-Roxana; Johannessen, Anne Christine; Suliman, Salwa; Mackenzie, Ian C.; Costea, Daniela Elena (Journal article; Peer reviewed, 2023)We aimed to investigate whether molecular clues from the extracellular matrix (ECM) can induce oral epithelial differentiation of pluripotent stem cells. Mouse embryonic stem cells (ESC) of the feeder-independent cell line ... -
Epithelial PD-L1 expression at tumor front predicts overall survival in a cohort of oral squamous cell carcinomas from Sudan
Mohamed, Nuha Mohamed Gaafar; Osman, Tarig Al-Hadi; Elsheikh, Mariam; Alhaj Ahmed, Israa Abdul Rhman Hassaballah; Dongre, Harsh Nitin; Fromreide, Siren; Suleiman, Ahmed M.; Johannessen, Anne Christine; Nginamau, Elisabeth Sivy; Costea, Daniela Elena (Journal article; Peer reviewed, 2022)Background We recently described the tumor immune microenvironment (TIME) in oral squamous cell carcinomas (OSCC) from Sudan by assessing the core of the lesions. However, the invasive tumor front (ITF) is the most active ... -
Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds.
Suliman, Salwa; Parajuli, Himalaya; Sun, Yang; Johannessen, Anne Christine; Finne-Wistrand, Anna; McCormack, Emmet; Mustafa, Kamal Babikeir Eln; Costea, Daniela Elena (Peer reviewed; Journal article, 2015)Background: Microenvironmental cues play a major role in head and neck cancer. Biodegradable scaffolds used for bone regeneration might also act as stimulative cues for head and neck cancer. The purpose of this study was ... -
Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential
Dongre, Harsh; Rana, Neha; Fromreide, Siren; Rajthala, Saroj; Engelsen, Ingeborg Bøe; Paradis, Justine; Gutkind, J. Silvio; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Bjørge, Line; Costea, Daniela Elena (Journal article; Peer reviewed, 2020)Vulvar squamous cell carcinoma associated with lichen sclerosus (VLS-VSCC) are rare tumors but with higher recurrence and worse prognosis than other types of VSCC. Lack of experimental models has limited the search for ... -
Feasibility of a portable electronic nose for detection of oral squamous cell carcinoma in sudan
Mohamed, Nazar; van de Goor, Rens; El-Sheikh, Mariam; Elrayah, Osman; Osman, Tarig; Nginamau, Elisabeth Sivy; Johannessen, Anne Christine; Suleiman, Ahmed; Costea, Daniela Elena; Kross, Kenneth W. (Journal article; Peer reviewed, 2021-05-03)Background: Oral squamous cell carcinoma (OSCC) is increasing at an alarming rate particularly in low-income countries. This urges for research into noninvasive, user-friendly diagnostic tools that can be used in ... -
Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better?
Steigen, Sonja E; Søland, Tine Merete; Nginamau, Elisabeth Sivy; Laurvik, Helene; Costea, Daniela-Elena; Johannessen, Anne Christine; Jebsen, Peter Wilhelm; Bjerkli, Inger-Heidi; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve (Peer reviewed; Journal article, 2020)Background: Numerous studies have been presented on histological grading of oral squamous cell carcinomas (OSCC) for predicting survival, but uncertainty of their usefulness rises due to discordances of results. A scoring ... -
Granulocyte macrophage-colony stimulating factor and keratinocyte growth factor control of early stages of differentiation of oral epithelium
Das, Ridhima; Virlan, Maria Justina Roxana; Xenaki, Victoria; Kulasekara, Keerthi Kumara; Lukandu, Ochiba Mohammed; Neppelberg, Evelyn; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Calenic, Bogdan; Costea, Daniela Elena (Journal article; Peer reviewed, 2022)Oral epithelial differentiation is known to be directed by underlying fibroblasts, but the responsible factor(s) have not been identified. We aimed here to identify fibroblast-derived factors responsible for oral epithelial ... -
Helicobacter pylori was not detected in oral squamous cell carcinomas from cohorts of Norwegian and Nepalese patients
Pandey, Sushma; Follin-Arbelet, Benoit; Bahadur Pun, Chin; K. Gautam, Dej; Johannessen, Anne Christine; Petersen, Fernanda Cristina; Costea, Daniela Elena; Sapkota, Dipak (Journal article; Peer reviewed, 2020)Helicobacter pylori (HP) infection is an established causative agent for gastric cancer. Although the oral cavity is a part of the gastrointestinal system, the presence and possible causative role of HP in oral squamous ... -
Inflammatory tissue reactions around aseptically loose cemented hip prostheses: A retrieval study of the Spectron EF stem with Reflection All-Poly acetabular cup
Wolf, Susann; Johannessen, Anne Christine; Ellison, Peter; Furnes, Ove Nord; Hallan, Geir; Rogg, Katharina; Skarstein, Kathrine; Høl, Paul Johan (Journal article; Peer reviewed, 2022)The cemented Spectron EF stem in combination with the cemented non-crosslinked Reflection All-Poly cup showed a high rate of mid-term aseptic loosening. However, the failure mechanisms are not fully known. We assessed the ... -
Influence of oral mucosal lesions and oral symptoms on oral health related quality of life in dermatological patients: a cross sectional study in Sudan
Suliman, Nada M.; Johannessen, Anne Christine; Ali, Raouf Wahab; Salman, Hussein; Åstrøm, Anne Nordrehaug (Peer reviewed; Journal article, 2012-07-08)Background: There are only few studies considering the impact of oral mucosal lesions (OML) on the oral quality of life of patients with different dermatological conditions. This study aimed to assess the relationship ... -
Integrin a11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression
Parajuli, Himalaya; Teh, Muy-Teck; Abrahamsen, Siren; Christoffersen, Ingeborg Monge; Neppelberg, Evelyn; Lybak, Stein; Osman, Tarig Al-Hadi; Johannessen, Anne Christine; Gullberg, Donald; Skarstein, Kathrine; Costea, Daniela Elena (Peer reviewed; Journal article, 2017-04)BACKGROUND: Cancer-associated fibroblasts (CAFs) were shown to be important for tumour progression in head and neck squamous cell carcinomas (HNSCCs). Their heterogeneity and lack of specific markers is increasingly ... -
Isolation and characterization of cells derived from human epithelial rests of Malassez
Kitajima, Kayoko; Das, Ridhima; Liang, Xiao; Neppelberg, Evelyn; Johannessen, Anne Christine; Costea, Daniela Elena; Igarashi, Masaru (Journal article; Peer reviewed, 2019)The epithelial rests of Malassez (ERMs) might represent a valuable source of oral epithelial cells with stem cell properties. The purpose of this study was to isolate and characterize cells derived from human ERM, and ... -
Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma
Pandey, Sushma; Osman, Tarig Al-Hadi; Sharma, Sunita; Vallenari, Evan Michael; Shahdafar, Aboulghassem; Pun, Chin B.; Gautam, Dej K.; Uhlin-Hansen, Lars; Rikardsen, Oddveig G; Johannessen, Anne Christine; Costea, Daniela Elena; Sapkota, Dipak (Journal article; Peer reviewed, 2020)Background We previously showed a tumor‐suppressive function of S100A14 in oral squamous cell carcinoma (OSCC). This study aimed to examine the prognostic significance and differentiation‐related function of S100A14 in ... -
The Low Affinity Nerve Growth Factor Receptor p75NTR Identifies a Transient Stem Cell-Like State in Oral Squamous Cell Carcinoma Cells
Osman, Tarig Al-Hadi; Costea, Daniela Elena; Parajuli, Himalaya; Sapkota, Dipak; Johannessen, Anne Christine; Ahmed, Israa A. H. (Peer reviewed; Journal article, 2014-09-12)Background Although several markers have been used for enrichment of cells with stem cell-like properties in oral squamous cell carcinoma (OSCC), isolation of a pure subpopulation is still a challenging task. Normal oral ... -
MicroRNA-138 abates fibroblast motility with effect on invasion of adjacent cancer cells
Rajthala, Saroj; Parajuli, Himalaya; Dongre, Harsh Nitin; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Sapkota, Dipak; Johannessen, Anne Christine; Costea, Daniela Elena (Journal article; Peer reviewed, 2022-03-17)Background: Recent studies have shown aberrant expression of micro-RNAs in cancer-associated fibroblasts (CAFs). This study aimed to investigate miR-138 dysregulation in CAFs in oral squamous cell carcinoma (OSCC) and its ... -
Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes
Suliman, Salwa; Mustafa, Kamal Babikeir Eln; Krueger, Anke; Steinmüller-Nethl, Doris; Finne-Wistrand, Anna; Osdal, Tereza; Osman, Amani Hamza Ali; Sun, Yang; Parajuli, Himalaya; Waag, Thilo; Nickel, Joachim; Johannessen, Anne Christine; McCormack, Emmet; Costea, Daniela Elena (Peer reviewed; Journal article, 2016-07)This study aimed to evaluate the tumorigenic potential of functionalising poly(LLA-co-CL) scaffolds. The copolymer scaffolds were functionalised with nanodiamonds (nDP) or with nDP and physisorbed BMP-2 (nDP-PHY) to enhance ...