• Characterization of FGD5 expression in primary breast cancers and lymph node metastases 

      Valla, Marit; Mjønes, Patricia; Engstrøm, Monica J; Ytterhus, Borgny; Bordin, Diana Lilian; van Loon, Barbara; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Peer reviewed; Journal article, 2018)
      Faciogenital dysplasia 5 (FGD5) amplification drives tumor cell proliferation, and is present in 9.5% of breast cancers. We describe FGD5 expression, assess associations between FGD5 amplification and FGD5 expression, and ...
    • FGD5 amplification in breast cancer patients is associated with tumor proliferation and a poorer prognosis 

      Valla, Marit; Engstrøm, Monica J; Ytterhus, Borgny; Hansen, Åse Kristin Skain; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Peer reviewed; Journal article, 2017-04)
      Purpose: Proliferation is a hallmark of cancer. Using a combined genomic approach, FGD5 amplification has been identified as a driver of proliferation in Luminal breast cancer. We aimed to describe FGD5 copy number change ...
    • Microvascular proliferation in luminal Aand basal-like breast cancer subtypes 

      Kraby, Maria Ryssdal; Krüger, Kristi; Opdahl, Signe; Vatten, Lars Johan; Akslen, Lars A.; Bofin, Anna M. (Peer reviewed; Journal article, 2015)
      Aims: The aims of this study were to examine microvessel density (MVD), proliferating MVD (pMVD) and Vascular Proliferation Index (VPI) in basal-like phenotype (BP) and luminal A subtypes of breast cancer and to study their ...
    • Molecular Subtypes of Breast Cancer: Long-term Incidence Trends and Prognostic Differences 

      Valla, Marit; Vatten, Lars Johan; Engstrøm, Monica J; Haugen, Olav Anton; Akslen, Lars A.; Bjørngaard, Johan Håkon; Hagen, Anne Irene; Ytterhus, Borgny; Bofin, Anna M.; Opdahl, Signe (Peer reviewed; Journal article, 2016-12)
      Background: Secular trends in incidence and prognosis of molecular breast cancer subtypes are poorly described. We studied long-term trends in a population of Norwegian women born 1886–1977. Methods: A total of 52,949 women ...
    • Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients 

      Engstrøm, Monica J; Opdahl, Signe; Hagen, Anne Irene; Romundstad, Pål Richard; Akslen, Lars A.; Haugen, Olav A.; Vatten, Lars Johan; Bofin, Anna M. (Peer reviewed; Journal article, 2013-08)
      Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. However, its clinical significance remains to be established. In this study, the main aims were to discover ...
    • MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes 

      Klæstad, Elise; Opdahl, Signe; Engstrøm, Monica J; Ytterhus, Borgny; Wik, Elisabeth; Bofin, Anna Mary; Valla, Marit (Journal article; Peer reviewed, 2020-01-16)
      Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 copy ...
    • Quantifying tumour vascularity in non-luminal breast cancers 

      Kraby, Maria Ryssdal; Opdahl, Signe; Akslen, Lars A.; Bofin, Anna M. (Peer reviewed; Journal article, 2017)
      Aims: Microvessel density (MVD), proliferating MVD (pMVD) and vascular proliferation index (VPI) are methods used to quantify tumour vascularity in histopathological sections. In this study, we assessed MVD, pMVD and VPI ...