Now showing items 1-10 of 22
Deficient phosphorylation of stat-1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta
(Public Library of Science, 2014-02-19)
Background: Anti interferon-beta (IFN-β) neutralizing antibodies (NAb) affect efficacy of treatment of multiple sclerosis patients, but exactly when the detrimental effects of NAbs offset therapeutic efficacy is debated. ...
Poor Sleep in Patients with Multiple Sclerosis
(Public Library of Science, 2012-11-14)
Background: Poor sleep is a frequent symptom in patients with multiple sclerosis (MS). Sleep may be influenced by MS-related symptoms and adverse effects from immunotherapy and symptomatic medications. We aimed to study ...
Dietary Vitamin D3 Supplements Reduce Demyelination in the Cuprizone Model
(Public Library of Science, 2011-10-20)
Vitamin D is emerging as a probably important environmental risk factor in multiple sclerosis, affecting both susceptibility and disease progression. It is not known to what extent this effect is due to a modulation of ...
Employment among patients with multiple sclerosis - A population study
(Public Library of Science, 2014-07-23)
Disease-modifying treatments for multiple sclerosis – a review of approved medications
Background and purpose: There is still no curative treatment for multiple sclerosis (MS), but during the last 20 years eight different disease-modifying compounds have been approved for relapsing remitting MS (RRMS). Methods: ...
The cost of multiple sclerosis in Norway
Health economic aspects have been increasingly important during introduction of new treatments for multiple sclerosis. As a partial response for Norway, a costof- illness study was carried out to estimate the yearly ...
Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort
(Nature Publishing Group, 2015)
In an attempt to map chromosomal regions carrying rare gene variants contributing to the risk of multiple sclerosis (MS), we identified segments shared identical-by-descent (IBD) using the software BEAGLE 4.0’s refined IBD ...
Month of birth and risk of multiple sclerosis: confoundingand adjustments
A month of birth effect on multiple sclerosis (MS) risk has been reported from different countries. Recent critics have suggested that this finding is caused by confounding and that adequately adjusting for year and place ...
mtDNA nt13708A Variant Increases the Risk of Multiple Sclerosis
Background: Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility. Methods and Findings: In order to investigate the ...
Fingolimod does not enhance cerebellar remyelination in the cuprizone model
Fingolimod (FTY720) is approved for treatment of relapsing–remitting multiple sclerosis. In vitro studies have found that fingolimod stimulates remyelination in cerebellar slices, but in vivo animal studies have not detected ...