Now showing items 1-10 of 26
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
(Nature Publishing Group, 2017)
A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple ...
Deficient phosphorylation of stat-1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta
(Public Library of Science, 2014-02-19)
Background: Anti interferon-beta (IFN-β) neutralizing antibodies (NAb) affect efficacy of treatment of multiple sclerosis patients, but exactly when the detrimental effects of NAbs offset therapeutic efficacy is debated. ...
Poor Sleep in Patients with Multiple Sclerosis
(Public Library of Science, 2012-11-14)
Background: Poor sleep is a frequent symptom in patients with multiple sclerosis (MS). Sleep may be influenced by MS-related symptoms and adverse effects from immunotherapy and symptomatic medications. We aimed to study ...
Dietary Vitamin D3 Supplements Reduce Demyelination in the Cuprizone Model
(Public Library of Science, 2011-10-20)
Vitamin D is emerging as a probably important environmental risk factor in multiple sclerosis, affecting both susceptibility and disease progression. It is not known to what extent this effect is due to a modulation of ...
Employment among patients with multiple sclerosis - A population study
(Public Library of Science, 2014-07-23)
Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: The EnvIMS study.
Background: Low vitamin D levels have been associated with an increased risk of multiple sclerosis (MS), although it remains unknown whether this relationship varies by age. Objective: The objective of this paper is to ...
Discovery and initial verification of differentially abundant proteins between multiple sclerosis patients and controls using iTRAQ and SID-SRM
In the present study, we aimed to discover cerebrospinal fluid (CSF) proteins with significant abundance difference between early multiple sclerosis patients and controls, and do an initial verification of these proteins ...
Fingolimod does not enhance cerebellar remyelination in the cuprizone model
Fingolimod (FTY720) is approved for treatment of relapsing–remitting multiple sclerosis. In vitro studies have found that fingolimod stimulates remyelination in cerebellar slices, but in vivo animal studies have not detected ...
A 60-year follow-up of the incidence and prevalence of multiple sclerosis in Hordaland County, Western Norway
Objective: Investigate the incidence of multiple sclerosis during 1953–2013 and estimate the prevalence rate of MS on 1 January 2003 and 2013 in Hordaland County, Western Norway. Methods: All patients with onset ...
Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model
Magnetization transfer ratio (MTR) is a magnetic resonance imaging (MRI) method which may detect demyelination not detected by conventional MRI in the central nervous system of patients with multiple sclerosis (MS). A ...