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Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation
Introduction: Increased intestinal hydration by activation of the epithelial enzyme linked receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation. Activating mutations in the GUCY2C ...
Bowel Perfusion Measured with Dynamic Contrast-enhanced Ultrasound Predicts Treatment Outcome in Patients with Crohn’s Disease
(Lippincott, Williams & WilkinsCrohn’s & Colitis Foundation of America, Inc, 2014-09-02)
Background: To improve management of patients with Crohn's disease (CD), objective measurements of the degree of local inflammation in the gastrointestinal wall are needed. Increased microvessel density and perfusion ...