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Molecular subtypes in stage II-III colon cancer defined by genomic instability: Early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A
(PLOS, 2015-04-16)
Objective: We sought to investigate various molecular subtypes defined by genomic instability that may be related to early death and recurrence in colon cancer.
Methods: We sought to investigate various molecular subtypes ...
Improving pancreas surgery over time: Performance factors related to transition of care and patient volume
(Elsevier, 2016-06-29)
Background: Pancreas surgery has evolved with better diagnostic imaging, changing indications, and improved patient selection. Outside high-volume tertiary centers, the documented effect of evolution in care and volumes ...
What Is the Best Predictor of Mortality in Perforated Peptic Ulcer Disease? A Population-Based, Multivariable Regression Analysis Including Three Clinical Scoring Systems
(Springer, 2014-03-08)
Background Mortality rates in perforated peptic ulcer (PPU) have remained unchanged. The aim of this study was to compare known clinical factors and three scoring systems (American Society of Anesthesiologists (ASA), Boey ...
Predicting outcomes in patients with perforated gastroduodenal ulcers: artificial neural network modelling indicates a highly complex disease
(Springer, 2014-06-14)
Purpose Mortality prediction models for patients with perforated peptic ulcer (PPU) have not yielded consistent or highly accurate results. Given the complex nature of this disease, which has many non-linear associations ...
Long-term follow-up and survivorship after completing systematic surveillance in stage I–III colorectal cancer: who is still at risk?
(Springer, 2015-09)
Purpose: In patients with a high life expectancy at the time of surgery for colorectal cancer (CRC), the long-term outcome may be influenced by factors other than their cancer. We aimed to investigate the long-term outcome ...
Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies
(Elsevier, 2015-02)
Background: Gastrointestinal stromal tumours (GISTs) are rare, yet the most common mesenchymal tumour within the digestive tract. Lack of diagnostic criteria and no specific code in the ICD system has prevented epidemiological ...
Epidemiology and classification of gastroenteropancreatic neuroendocrine neoplasms using current coding criteria
(Wiley, 2016-02)
Background: The lack of uniform criteria for coding of gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) has hampered previous epidemiological studies. The epidemiology of GEP-NEN was investigated in this study ...
Clinical patterns of presentation and attenuated inflammatory response in octo- and nonagenarians with perforated gastroduodenal ulcers
(Elsevier, 2016-08)
Background. Perforated gastrodudenal ulcer (PGDU) is an operative emergency with high mortality rates. The growing elderly populationincreasingly presents with need for geriatric acute operative care. Current knowledge of ...
Assessment of clinically related outcomes and biomarker analysis for translational integration in colorectal cancer (ACROBATICC): study protocol for a population-based, consecutive cohort of surgically treated colorectal cancers and resected colorectal liver metastasis
(BioMed Central, 2016-06-29)
Background: More accurate predictive and prognostic biomarkers for patients with colorectal cancer (CRC) primaries or colorectal liver metastasis (CLM) are needed. Outside clinical trials, the translational integration of ...