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Assessment of retention force and bone apposition in two differently coated femoral stems after 6 months of loading in a goat model
(BioMed Central, 2014-08-16)
Background: Since the introduction of uncemented hip implants, there has been a search for the best surface
coating to enhance bone apposition in order to improve retention. The surface coating of the different stems ...
Prevalence and implications of elevated microsatellite alterations at selected tetranucleotides in cancer
(Nature Publishing Group, 2014-04-01)
Elevated microsatellite alterations at selected tetranucleotides (EMAST), a variation of microsatellite instability (MSI), has been reported in a variety of malignancies (e.g., neoplasias of the lung, head and neck, ...
Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients
(BioMed Central, 2017-09-05)
Background: Patients with early colorectal cancer (stages I–II) generally have a good prognosis, but a subgroup of 15–20% experiences relapse and eventually die of disease. Occult metastases have been suggested ...
Molecular subtypes in stage II-III colon cancer defined by genomic instability: Early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A
(PLOS, 2015-04-16)
Objective: We sought to investigate various molecular subtypes defined by genomic instability that may be related to early death and recurrence in colon cancer.
Methods: We sought to investigate various molecular subtypes ...
Using patient-reported outcome measures for improved decision-making in patients with gastrointestinal cancer – the last clinical frontier in surgical oncology?
(Frontiers, 2013-06-14)
The genomic era has introduced concepts of “personalized medicine” and “targeted therapy” in the field of oncology. Medicine has become increasingly complex with a plethora of potential dilemmas in diagnosis, treatment, ...
Improving pancreas surgery over time: Performance factors related to transition of care and patient volume
(Elsevier, 2016-06-29)
Background: Pancreas surgery has evolved with better diagnostic imaging, changing indications, and improved patient selection. Outside high-volume tertiary centers, the documented effect of evolution in care and volumes ...
What Is the Best Predictor of Mortality in Perforated Peptic Ulcer Disease? A Population-Based, Multivariable Regression Analysis Including Three Clinical Scoring Systems
(Springer, 2014-03-08)
Background Mortality rates in perforated peptic ulcer (PPU) have remained unchanged. The aim of this study was to compare known clinical factors and three scoring systems (American Society of Anesthesiologists (ASA), Boey ...
Determining universal processes related to best outcome in emergency abdominal surgery: A multicentre, international, prospective cohort study
(BMJ, 2014-10-29)
Introduction: Emergency abdominal surgery outcomes represent an internationally important marker of healthcare quality and capacity. In this study, a novel approach to investigating global surgical outcomes is proposed, ...
Can bone apposition predict the retention force of a femoral stem? An experimental weight-bearing hip-implant model in goats
(BioMed Central, 2015-04-28)
Background: The increasing incidence of prosthesis revision surgery in the Western world has led to an increased
focus on the capacity for stem removal. We previously reported on a femoral stem implanted in goats with ...
Predicting outcomes in patients with perforated gastroduodenal ulcers: artificial neural network modelling indicates a highly complex disease
(Springer, 2014-06-14)
Purpose Mortality prediction models for patients with perforated peptic ulcer (PPU) have not yielded consistent or highly accurate results. Given the complex nature of this disease, which has many non-linear associations ...