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Extra-colonic cancers in Lynch Syndrome
(The University of Bergen, 2010-11-12)
Lynch Syndrome (LS) is the most common of the hereditary colorectal cancer (CRC) syndromes. It is caused by germ-line mutations in one of the four mismatch repair (MMR) genes MLHl, MSH2, MSH6 or PMS2. Mutations in one of ...
Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers
(BMJ Publishing Group, 2010-09)
Background: Reported prevalence, penetrance and expression of deleterious mutations in the mismatch repair (MMR) genes, MLH1, MSH2, MSH6 and PMS2, may reflect differences in the clinical criteria used to select families ...