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Assessment of clinically related outcomes and biomarker analysis for translational integration in colorectal cancer (ACROBATICC): study protocol for a population-based, consecutive cohort of surgically treated colorectal cancers and resected colorectal liver metastasis
(BioMed Central, 2016-06-29)
Background: More accurate predictive and prognostic biomarkers for patients with colorectal cancer (CRC) primaries or colorectal liver metastasis (CLM) are needed. Outside clinical trials, the translational integration of ...
Primary Leiomyosarcoma of the Pancreas—a Case Report and a Comprehensive Review
(Springer, 2016-12)
Purpose: Primary mesenchymal tumors of the pancreas are rare, with leiomyosarcomas the most encountered entities among the pancreatic sarcomas. With few exceptions, single case reports published over the last six decades ...
Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis
(Springer, 2016-11)
Background: Perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with risk of anastomotic leak (AL). However, concomitant use of other drugs could infer a bias in risk assessment. Thus, we aimed ...
Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways
(Elsevier, 2014-03-12)
The interconnectivity between diet, gut microbiota and cell molecular responses is well known; however, only recently has technology allowed the identification of strains of microorganisms harbored in the gastrointestinal ...
Comparison of CpG Island Methylator Phenotype (CIMP) Frequency in Colon Cancer Using Different Probe- and Gene-Specific Scoring Alternatives on Recommended Multi-Gene Panels
(PLoS, 2014-01-21)
Background: In colorectal cancer a distinct subgroup of tumours demonstrate the CpG island methylator phenotype (CIMP).
However, a consensus of how to score CIMP is not reached, and variation in definition may influence ...
Scoring systems for outcome prediction in patients with perforated peptic ulcer
(BioMed Central, 2013-04-10)
Background:
Patients with perforated peptic ulcer (PPU) often present with acute, severe illness that carries a high
risk for morbidity and mortality. Mortality ranges from 3-40% and several prognostic scoring systems ...
Influence of microsatellite instability and KRAS and BRAF mutations on lymph node harvest in stage I–III colon cancers
(Feinstein Institute for Medical Research, 2013)
Lymph node (LN) harvest is influenced by several factors, including tumor genetics. Microsatellite instability (MSI) is associated with
improved node harvest, but the association to other genetic factors is largely unknown. ...
Emergency surgery in the elderly: the balance between function, frailty, fatality and futility
(BioMed Central, 2015-02-03)
Becoming old is considered a privilege and results from the socioeconomic progress and improvements in health
care systems worldwide. However, morbidity and mortality increases with age, and even more so in acute ...