Blar i Department of Clinical Medicine på tittel
Viser treff 212-231 av 2095
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Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
(Peer reviewed; Journal article, 2017-05-17)The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ... -
Cancer cell line-specific protein profiles in extracellular vesicles identified by proteomics
(Journal article; Peer reviewed, 2020-09-04)Extracellular vesicles (EVs), are important for intercellular communication in both physiological and pathological processes. To explore the potential of cancer derived EVs as disease biomarkers for diagnosis, monitoring, ... -
Cancer epigenetics in solid organ tumours: A primer for surgical oncologists
(Peer reviewed; Journal article, 2019-05)Cancer is initiated through both genetic and epigenetic alterations. The end-effect of such changes to the DNA machinery is a set of uncontrolled mechanisms of cell division, invasion and, eventually, metastasis. Epigenetic ... -
Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study
(Peer reviewed; Journal article, 2017-12-18)Background. Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk. Objectives. To quantify the cancer risk associated with contemporary ... -
Cancer related mortality in multiple sclerosis. A population based cohort study
(Journal article; Peer reviewed, 2023)Background: Cancer is a major cause of death, but how cancer influences mortality risk in Multiple Sclerosis (MS) is unclear. Objectives: Determine all-cause mortality and mortality following a cancer diagnosis among ... -
Cancer risk in children of mothers with epilepsy and high-dose folic acid use during pregnancy
(Journal article; Peer reviewed, 2022)Importance: Women with epilepsy are recommended high doses of folic acid before and during pregnancy owing to risk of congenital anomalies associated with antiseizure medications. Whether prenatal exposure to high-dose ... -
Cancer Stem Cell-Related Markers in Normal and Neoplastic Oral Mucosa. A study on human samples and experimental models
(Doctoral thesis, 2014-06-04)The existence of cancer stem cells (CSCs) in solid cancers is still a controversial issue. Several markers were successfully used to enrich for cells with stem cell-like properties in oral squamous cell carcinoma (OSCC). ... -
Cancer-Associated Ischemic Stroke: The Bergen NORSTROKE Study
(Doctoral thesis, 2018-05-25)Background: Stroke and cancer are both leading causes of death and disability in the Western world. Cancer can lead to a hypercoagulable state that can cause ischemic stroke. Mechanisms include disturbance of the coagulation ... -
Cancer-Associated stroke: The Bergen NORSTROKE Study
(Peer reviewed; Journal article, 2015-10-13)Background: Underlying malignancy can cause ischemic stroke in some patients. Mechanisms include the affection of the coagulation cascade, tumor mucin secretion, infections and nonbacterial endocarditis. The release of ... -
Cancer-related fatigue and treatment burden in surgically treated colorectal cancer patients – A cross-sectional study
(Journal article; Peer reviewed, 2021)Objective This cross-sectional study aimed to describe cancer-related fatigue (CRF) in colorectal cancer (CRC) patients who were surgically treated with curative intent, identify subgroups at risk of elevated fatigue ... -
The cannabis pathway to non-affective psychosis may reflect less neurobiological vulnerability
(Peer reviewed; Journal article, 2014-11-18)There is a high prevalence of cannabis use reported in non-affective psychosis. Early prospective longitudinal studies conclude that cannabis use is a risk factor for psychosis, and neurochemical studies on cannabis have ... -
Capillary leakage in post-cardiac arrest survivors during therapeutic hypothermia - a prospective, randomised study
(Peer reviewed; Journal article, 2010-05-25)Background: Fluids are often given liberally after the return of spontaneous circulation. However, the optimal fluid regimen in survivors of cardiac arrest is unknown. Recent studies indicate an increased fluid requirement ... -
Carboxyl ester lipase in pancreatic disease : In vitro and in vivo studies of human pathogenic CEL mutations
(Doctoral thesis, 2023-03-21)Karboksylester-lipase (CEL) er et fordøyelsesenzym som hovedsakelig er uttrykt i bukspytt-kjertelen. Det siste eksonet i CEL-genet inneholder et variabelt antall tandem repetisjoner (VNTR), altså en region av repeterte ... -
Carboxyl-ester lipase in human pancreatic disease. A study with focus on genetics, glycosylation and ABO blood groups
(Doctoral thesis, 2018-09-28)Glycosylation is a post-translational modification where carbohydrates are attached to a protein or other organic molecule. Defects in glycosylation are seen in many human pathologies and may even be the underlying cause ... -
Cardiac Arrest in a Community: Epidemiology, Treatment, and Outcome
(Doctoral thesis, 2017-09-01)Background: Incidence and mortality from sudden cardiac arrest is high, making it a prevalent cause of death. Both incidence and survival rates show great variability between populations. In order to improve survival from ... -
Cardiac Structure and Function in Epilepsy Patients with Drug-Resistant Convulsive Seizures
(Journal article; Peer reviewed, 2022)High frequency of convulsive seizures and long-lasting epilepsy are associated with an increased risk of sudden unexpected death in epilepsy (SUDEP). Structural changes in the myocardium have been described in SUDEP victims. ... -
Cardiac Structure and Function in Epilepsy Patients with Drug-Resistant Convulsive Seizures
(Journal article; Peer reviewed, 2022)High frequency of convulsive seizures and long-lasting epilepsy are associated with an increased risk of sudden unexpected death in epilepsy (SUDEP). Structural changes in the myocardium have been described in SUDEP victims. ... -
Cardiovascular changes in young renal failure patients
(Journal article; Peer reviewed, 2021)Progresses in medical care of severe kidney disease and congenital anomalies of kidney and urinary tract make it possible for a higher percentage of young renal failure patients to survive and enter adulthood. There is ... -
Carotid intima-media thickness and cerebrovascular vasoreactivity in patients with intracranial aneurysms : A sonographic study of potential predictors for aneurysm rupture risk and delayed cerebral ischemia
(Doctoral thesis, 2020-04-03)Background and aims Intracranial aneurysms can rupture and cause an aneurysmal subarachnoid hemorrhage (aSAH), a bleeding under the arachnoid meninges covering the brain. This is a devastating event, in which delayed ... -
Case Report: Limbic encephalitis following treatment with durvalumab for small-cell lung cancer
(Journal article; Peer reviewed, 2023-10-16)Background: Durvalumab is an immune checkpoint Inhibitor (ICIs) that is used in the treatment of malignant tumors, such as lung cancer and melanoma. ICIs are associated with immune-related adverse events including autoimmune ...