Blar i Department of Clinical Medicine på tittel
Viser treff 438-457 av 2095
-
Default-mode network functional connectivity is closely related to metabolic activity
(Peer reviewed; Journal article, 2015-06)Over the last decade, the brain's default-mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more ... -
Defective i⁶A37 Modification of Mitochondrial and Cytosolic tRNAs Results from Pathogenic Mutations in TRIT1 and Its Substrate tRNA
(Peer reviewed; Journal article, 2014-06-05)Identifying the genetic basis for mitochondrial diseases is technically challenging given the size of the mitochondrial proteome and the heterogeneity of disease presentations. Using next-generation exome sequencing, we ... -
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
(Peer reviewed; Journal article, 2016-11-22)Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we ... -
Deficiency of the metabolic enzyme SCHAD in pancreatic β-cells promotes amino acid–sensitive hypoglycemia
(Journal article; Peer reviewed, 2023)Congenital hyperinsulinism of infancy (CHI) can be caused by a deficiency of the ubiquitously expressed enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD). To test the hypothesis that SCHAD-CHI arises from a specific ... -
Deficient phosphorylation of stat-1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta
(Peer reviewed; Journal article, 2014-02-19)Background: Anti interferon-beta (IFN-β) neutralizing antibodies (NAb) affect efficacy of treatment of multiple sclerosis patients, but exactly when the detrimental effects of NAbs offset therapeutic efficacy is debated. ... -
Defining Transabdominal Intestinal Ultrasound Treatment Response and Remission in Inflammatory Bowel Disease: Systematic Review and Expert Consensus Statement
(Journal article; Peer reviewed, 2021)Background and Aims No consensus exists on defining intestinal ultrasound response, transmural healing, or transmural remission in inflammatory bowel disease, nor clear guidance for optimal timing of assessment during ... -
Deformation and initial stability in hip arthroplasty. Effect of neck geometry and fixation – an experimental cadaver study
(Doctoral thesis, 2017-06-08)Introduction: The search for and development of the optimal joint implant include preclinical testing. Restoration of the individual and natural biomechanics in the hip joint is a central goal in hip arthroplasty, and can ... -
Degenerative bony changes in the temporal component of the temporomandibular joint – review of the literature
(Journal article; Peer reviewed, 2022)Temporomandibular joint (TMJ) changes are quite frequent in adults, but not all changes are degenerative. A high prevalence of bone alterations in the TMJs was reported by different research groups. Disturbed remodeling ... -
Delirium is frequently underdiagnosed among older hospitalised patients despite available information in hospital medical records
(Journal article; Peer reviewed, 2024)Background In-hospital delirium is associated with adverse outcomes and is underdiagnosed, limiting research and clinical follow-up. Objective To compare the incidence of in-hospital delirium determined by chart-based ... -
The Delta III and Delta Xtend reverse shoulder arthroplasty. Risk of revision and failure mechanisms: a report on 3,650 cases from the Norwegian Arthroplasty Register 1994-2021
(Journal article; Peer reviewed, 2024)Background: The Delta reverse shoulder arthroplasty (RSA) is commonly used worldwide and is the most frequently used RSA in Norway. The aim of this registry-based study was to report 10- and 20-year implant survival, risk ... -
Demens med Lewylegemer: søvn, kognisjon og nevropatologi
(Doctoral thesis, 2019-01-17)Background Sleep disorders are frequent in patients with dementia. Sleep disturbances can negatively influence the disease burden of dementia and accelerate the rate of cognitive decline. It is hypothesized that sleep ... -
Dementia with Lewy Bodies. Identification, frequency and sleep-disturbances. A cross-sectional clinical dementia cohort study
(Doctoral thesis, 2011-02-18)Background: Dementia with Lewy Bodies (DLB) has existed as a formal consensus diagnosis since 1996 and is defined by dementia and the core features parkinsonism, visual hallucinations and cognitive fluctuations. The original ... -
Densities of rectal peptide YY and somatostatin cells as biomarkers for the diagnosis of irritable bowel syndrome
(Peer reviewed; Journal article, 2015-03-09)Irritable bowel syndrome (IBS) is a common chronic disorder. IBS diagnosis is a diagnosis of exclusion since there are no blood tests, radiological or endoscopic examinations for this disorder. Although several attempts ... -
Density of Musashi‑1‑positive stem cells in the stomach of patients with irritable bowel syndrome
(Journal article; Peer reviewed, 2020)Irritable bowel syndrome (IBS) affects ~12% of the global population. Although the etiology of IBS is not completely understood, several factors are known to serve a pivotal role in its pathophysiology, including genetic ... -
Deoxyribonucleoside treatment rescues EtBr-induced mtDNA depletion in iPSC-derived neural stem cells with POLG mutations
(Journal article; Peer reviewed, 2023)Mutations in POLG, the gene encoding the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol-γ), lead to diseases driven by defective mtDNA maintenance. Despite being the most prevalent cause of ... -
Depresjon og andre subjektive helseplager hos pasientar med korsryggsmerter. Har inntak av sjømat og vitamin D-status noko betyding?
(Master thesis, 2014-05-15)Background: Vitamin D is found in limited selections of food, among other fatty fish and fish liver, as well as fortified food such as margarine and milk. Other vitamin D sources are dietary supplements and sunlight. Low ... -
Depression and migraine comorbid to diabetes
(Doctoral thesis, 2014-12-04)Background: Diabetes, depression and migraine are prevalent diseases in the Norwegian population, and have great impact on patients life in terms of disability. Diabetes is a systemic disease manifesting in a range of organ ... -
Depression in Parkinson’s disease
(Doctoral thesis, 2010-05-07) -
Depression trajectories and cytokines in schizophrenia spectrum disorders - A longitudinal observational study
(Journal article; Peer reviewed, 2023)Depression occurs frequently in all phases of schizophrenia spectrum disorders. Altered activity in the immune system is seen in both depression and schizophrenia. We aimed to uncover depressive trajectories in a sample ... -
Depressive symptoms in psychotic disorders : Trajectories of depression and antidepressive effectiveness of antipsychotic medication
(Doctoral thesis, 2020-10-16)Background: Depressive symptoms are common in psychotic disorders and contribute to impaired functioning, a poorer quality of life, elevated relapse rate and suicide risk. Depression in schizophrenia may emerge as part of ...