Blar i Department of Clinical Medicine på tittel
Viser treff 523-542 av 2043
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DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion
(Journal article; Peer reviewed, 2021)Mutations in POLG, encoding POLγA, the catalytic subunit of the mitochondrial DNA polymerase, cause a spectrum of disorders characterized by mtDNA instability. However, the molecular pathogenesis of POLG-related diseases ... -
Do direct oral anticoagulants (DOACs) cause delayed surgery, longer length of hospital stay, and poorer outcome for hip fracture patients?
(Journal article; Peer reviewed, 2020)Purpose The perioperative consequences of direct oral anticoagulants (DOACs) in hip fracture patients are not sufficiently investigated. The primary aim of this study was to determine whether DOAC-users have delayed surgery ... -
Do nonsteroidal anti-inflammatory drugs affect the outcome of arthroscopic Bankart repair?
(Peer reviewed; Journal article, 2014-04-22)To achieve pain control after arthroscopic shoulder surgery, nonsteroidal anti-inflammatory drugs (NSAIDs) are a complement to other analgesics. However, experimental studies have raised concerns that these drugs may have ... -
Does a parental history of cancer moderate the associations between impaired health status in parents and psychosocial problems in teenagers: a HUNT study.
(Peer reviewed; Journal article, 2014-08)Severe disease in a parent is associated with increased psychosocial problems in their children. However, moderating factors of such associations are less studied. In this cross-sectional population-based controlled study ... -
Does changing from a first generation antipsychotic (perphenazin) to a second generation antipsychotic (risperidone) alter brain activation and motor activity? A case report
(Peer reviewed; Journal article, 2013-05-06)Background: In patients with schizophrenia, altered brain activation and motor activity levels are central features, reflecting cognitive impairments and negative symptoms, respectively. Newer studies using nonlinear methods ... -
Does childhood trauma influence cognitive functioning in schizophrenia? The association of childhood trauma and cognition in schizophrenia spectrum disorders.
(Journal article; Peer reviewed, 2020)Childhood trauma (CT) is a risk factor for schizophrenia spectrum disorders (SSDs), and cognitive impairment is a core feature and a vulnerability marker of SSDs. Studies of the relationship between CT and cognitive ... -
Does choice of bearings influence the survival of cement-less total hip arthroplasty in patients aged 20–55 years? Comparison of 21,594 patients reported to the Nordic Arthroplasty Register Association dataset 2005–2017
(Journal article; Peer reviewed, 2023)Background and purpose: The bearings with the best survivorship for young patients with total hip arthroplasty (THA) should be identified. We compared hazard ratios (HR) of revision of primary stemmed cementless THAs with ... -
Does maternal genetic liability to folate deficiency influence the risk of antiseizure medication-associated language impairment and autistic traits in children of women with epilepsy?
(Journal article; Peer reviewed, 2023)Background: Prenatal exposure to antiseizure medication (ASM) may lead to low plasma folate concentrations and is associated with impaired neurodevelopment. Objectives: To examine whether maternal genetic liability to ... -
Dog-assisted interventions for adults diagnosed with schizophrenia and related disorders: a systematic review
(Journal article; Peer reviewed, 2023)Background: Many individuals diagnosed with schizophrenia and related disorders experience insufficient symptom relief from currently available treatment options. Researching additional venues should be prioritized. This ... -
“Don’t Think Twice, It’s All Right”: Using Additional Data to Reduce Uncertainty Regarding Oncologic Drugs Provided Through Managed Access Agreements in England
(Journal article; Peer reviewed, 2022)Objectives The Cancer Drugs Fund (CDF) in England uses managed access agreements to facilitate additional data collection to address uncertainties identified in the appraisals of new drugs. This study reviews the uncertainties ... -
Dose Constraints for important Organs at Risk in the Head and Neck Region for Carbon Ion Radiotherapy optimized with the Local Effect Model I (LEM I)
(Doctoral thesis, 2021-03-25)Carbon ion radiotherapy (CIRT) exhibits higher relative biological effectiveness (RBE), compared to photon and proton RT. However, there are substantial uncertainties regarding the clinical RBE of carbon ions. Therefore, ... -
Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs
(Peer reviewed; Journal article, 2006-10-20)Background: The etiology of schizophrenia is unknown, but neurodevelopmental disturbances, myelin- and oligodendrocyte abnormalities and synaptic dysfunction have been suggested as pathophysiological factors in this severe ... -
Drusenoid pigment epithelial detachment volume is associated with a decrease in best-corrected visual acuity and central retinal thickness: the Norwegian Pigment Epithelial Detachment Study (NORPED) report no. 1
(Journal article; Peer reviewed, 2020)Purpose To investigate the association of drusenoid pigment epithelial detachment (DPED) volume and change in best‐corrected visual acuity (BCVA) and central retinal thickness (CRT) during the growth phase of large ... -
Duodenal administered seal oil for patients with subjective food hypersensitivity: an explorative open pilot study
(Peer reviewed; Journal article, 2010-12)Short-term duodenal administration of n-3 polyunsaturated fatty acid (PUFA)-rich seal oil may improve gastrointestinal complaints in patients with subjective food hypersensitivity, as well as joint pain in patients with ... -
Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome
(Peer reviewed; Journal article, 2014-06-16)Background and Aim. Chromogranin A (CgA) is a common marker for endocrine cells. The density of duodenal CgA cells is reduced in patients with irritable bowel syndrome (IBS). Methods. The present study was undertaken to ... -
Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patients
(Journal article; Peer reviewed, 2022)Background Neutralizing antibodies are important for protection against the pandemic SARS-CoV-2 virus, and long-term memory responses determine the risk of re-infection or boosting after vaccination. T-cellular responses ... -
Dynamic contrast-enhanced MRI shows altered blood–brain barrier function of deep gray matter structures in neuroborreliosis: a case–control study
(Journal article; Peer reviewed, 2023)Background Main aim was assessment of regional blood–brain barrier (BBB) function by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with neuroborreliosis. Secondary aim was to study the correlation ... -
The Dynamics and Prognostic Potential of DNA Methylation Changes at Stem Cell Gene Loci in Women's Cancer
(Peer reviewed; Journal article, 2012-02-09)Aberrant DNA methylation is an important cancer hallmark, yet the dynamics of DNA methylation changes in human carcinogenesis remain largely unexplored. Moreover, the role of DNA methylation for prediction of clinical ... -
Dynamics of Plasma and Urinary Extracellular DNA in Acute Kidney Injury
(Journal article; Peer reviewed, 2022)Early and reliable markers of acute kidney injury (AKI) are essential. One such candidate marker of tissue damage is extracellular DNA (ecDNA). The aim of our present study is to describe the unknown dynamics of ecDNA in ... -
Dyslipidemia and rupture risk of intracranial aneurysms—a systematic review
(Journal article; Peer reviewed, 2021)Dyslipidemia is a well-established risk factor for coronary artery disease. However, the effect on cerebral artery disease, and more specifically the rupture risk of intracranial aneurysms, is unclear and has not yet been ...