Blar i Department of Clinical Medicine på forfatter "Ytre-Hauge, Sigmund"
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Advanced imaging biomarkers in endometrial cancer
Ytre-Hauge, Sigmund (Doctoral thesis, 2019-12-11)Background: Endometrial cancer is the most common gynecological cancer in highdeveloped regions of the world, and the incidence has been increasing over the last half century, largely driven by a concurrent increase in ... -
MRI-assessed tumor-free distance to serosa predicts deep myometrial invasion and poor outcome in endometrial cancer
Dybvik, Julie Andrea; Fasmer, Kristine Eldevik; Ytre-Hauge, Sigmund; Husby, Jenny Hild Aase; Salvesen, Øyvind; Stefansson, Ingunn Marie; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2022)Objectives To explore the diagnostic accuracy of preoperative magnetic resonance imaging (MRI)-derived tumor measurements for the prediction of histopathological deep (≥ 50%) myometrial invasion (pDMI) and prognostication ... -
An mri-based radiomic prognostic index predicts poor outcome and specific genetic alterations in endometrial cancer
Jacob, Havjin; Dybvik, Julie Andrea; Ytre-Hauge, Sigmund; Fasmer, Kristine E.; Høivik, Erling Andre; Trovik, Jone; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021)Integrative tumor characterization linking radiomic profiles to corresponding gene expression profiles has the potential to identify specific genetic alterations based on non-invasive radiomic profiling in cancer. The aim ... -
Preoperative 18F-FDG PET/CT tumor markers outperform MRI-based markers for the prediction of lymph node metastases in primary endometrial cancer
Fasmer, Kristine Eldevik; Gulati, Ankush; Dybvik, Julie Andrea; Ytre-Hauge, Sigmund; Salvesen, Øyvind; Trovik, Jone; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2020)Objectives To compare the diagnostic accuracy of preoperative 18F-FDG PET/CT and MRI tumor markers for prediction of lymph node metastases (LNM) and aggressive disease in endometrial cancer (EC). Methods Preoperative ... -
Preoperative tumor size at MRI predicts deep myometrial invasion, lymph node metastases, and patient outcome in endometrial carcinomas
Ytre-Hauge, Sigmund; Husby, Jenny Hild Aase; Magnussen, Inger Johanne; Werner, Henrica Maria Johanna; Salvesen, Øyvind; Bjørge, Line; Trovik, Jone; Stefansson, Ingunn; Salvesen, Helga Birgitte; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2015)OBJECTIVE: The aim of this study was to explore the relation between preoperative tumor size based on magnetic resonance imaging (MRI) and the surgical pathologic staging parameters (deep myometrial invasion, cervical ... -
Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer
Berg, Anna; Fasmer, Kristine Eldevik; Mauland, Karen Klepsland; Ytre-Hauge, Sigmund; Høivik, Erling Andre; Husby, Jenny Hild Aase; Tangen, Ingvild Løberg; Trovik, Jone; Halle, Mari Kyllesø; Woie, Kathrine; Bjørge, Line; Bjørnerud, Atle; Salvesen, Helga; Werner, Henrica Maria Johanna; Krakstad, Camilla; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2016-09-13)Hypoxia is frequent in solid tumors and linked to aggressive phenotypes and therapy resistance. We explored expression patterns of the proposed hypoxia marker HIF-1α in endometrial cancer (EC) and investigate whether ... -
Tumour texture features from preoperative CT predict high-risk disease in endometrial cancer
Ytre-Hauge, Sigmund; Salvesen, Øyvind; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021-01)Background: To enable more individualised treatment of endometrial cancer, improved methods for preoperative tumour characterization are warranted. Texture analysis is a method for quantification of heterogeneity in images, ...