Introduction: To address the growing incidence of hip replacement revision, this project aimed to find a stem that would fulfil three criteria. First, solid osteointegration and long survival of the implant. Second, ...

Background: Next to Alzheimer’s disease, Parkinson’s disease (PD) is the second most neurodegenerative disease. As the population structure in the industrialized and industrializing countries is changing, an increasing ...

Background: In total knee replacement surgery (TKR), the surgeon aims to align the implant according to the mechanical axis of the limb. Among knee surgeons the dominating belief is that good alignment reduces wear and ...

The sleep-wake cycle, lipid metabolism and hormone levels are examples of circadian rhythms, which are endogenously generated cycles that reach both maximum and minimum values once in the course of 24 hours. In ...

Background: Cognitive impairment is common even in newly diagnosed Parkinson’s disease (PD), and characteristically involves executive and visuospatial functions with deficits also in the memory domain. There is an ...

Objectives: The objectives of the thesis were to describe the functional level (papers I and II) and self awareness of functional deficits (paper III) after moderate and severe Traumatic Brain Injury (TBI), and to ...

Background: Lyme borreliosis (LB) caused by the bacteria Borrelia burgdorferi sensu lato (Bbsl) is the most common tick transmitted infection in Europe. LB is a multi systemic infection that develops when the bacteria ...

Antipsychotic agents represent efficient therapy for serious psychiatric disorders, particularly schizophrenia, but also bipolar disorder, and are used by millions of patients worldwide. Metabolic adverse effects of ...