• Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults 

  Hemminghyth, Mathilde Suhr; Chwiszczuk, Luiza; Breitve, Monica Haraldseid; Gisladottir, Berglind; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Rongve, Arvid; Fladby, Tormod; Kirsebom, Bjørn-Eivind Seljelid (Journal article; Peer reviewed, 2023)

  Multiple cognitive domains, including learning, memory, and psychomotor speed, show significant reductions with age. Likewise, several cerebrospinal fluid (CSF) neurodegenerative biomarkers, including total tau (t-tau, a ...

• Single use flexible ureteroscopes: Current status and future directions 

  Juliebø-Jones, Patrick; Ventimiglia, Eugenio; Somani, Bhaskar K.; Æsøy, Mathias S.; Gjengstø, Peder; Beisland, Christian; Ulvik, Øyvind (Journal article; Peer reviewed, 2023)

  Introduction: Single use ureteroscopes are a technological innovation that have become available in the past decade and gained increased popularity. To this end, there are now an increasing number of both benchside and ...

• Tenecteplase, 0.4 mg/kg, in Moderate and Severe Acute Ischemic Stroke: A Pooled Analysis of NOR-TEST and NOR-TEST 2A 

  Novotny, Vojtech; Kvistad, Christopher Elnan; Næss, Halvor; Logallo, Nicola; Fromm, Annette; Khanevski, Andrej; Thomassen, Lars (Journal article; Peer reviewed, 2023)

  Background: The optimal dose of tenecteplase in acute ischemic stroke remains to be defined. We present a pooled analysis of the 2 NOR‐TESTs (Norwegian Tenecteplase Stroke Trials) exploring the efficacy and safety of ...

• Pharmacokinetics of epinephrine during cardiac arrest: A pilot study 

  Heradstveit, Bård Einar; Sunde, Geir Arne; Asbjørnsen, Helge; Aalvik, Rune; Wentzel-Larsen, Tore; Heltne, Jon-Kenneth (Journal article; Peer reviewed, 2023)

  Aim of the study: Epinephrine has been recommended for several decades for the treatment of cardiac arrest. However, although this potent medicament has a documented impact on the return of spontaneous circulation, it does ...

• Cementing techniques for total knee arthroplasty in Norwegian hospitals; a questionnaire-based study 

  Khan, Michelle; Gjertsen, Jan-Erik; Fenstad, Anne Marie; Refsum, Anders Myhre; Nguyen, Uy Viet; Hallan, Geir; Høl, Paul Johan; Furnes, Ove Nord (Journal article; Peer reviewed, 2023-11-18)

  Background: Cementing technique in total knee arthroplasty (TKA) may influence implant survival. There is limited knowledge about the results with clinically used techniques. The aim of this study was to investigate ...

• Case report: Seropositive myasthenia gravis complicated by limbic encephalitis positive for antibodies to AMPAR and Lgi1 

  Nes, Magne Solberg; Haugen, Mette; Haugland, Hans Kristian; Gilhus, Nils Erik; Vedeler, Christian Alexander (Journal article; Peer reviewed, 2023-10-12)

  Objectives: Autoantibodies to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and leucine-rich glioma-inactivated 1 (Lgi1) are associated with autoimmune encephalitis. We described an acetylcholine ...

• Longer-term quality of care, effectiveness, and cost-effectiveness of implementing a model of care for osteoarthritis: A cluster-randomized controlled trial 

  Østerås, Nina; Aas, Eline; Moseng, Tuva; van Bodegom-Vos, Leti; Dziedzic, Krysia; Natvig, Bård; Røtterud, Jan H; Vlieland, Thea Vliet; Furnes, Ove Nord; Fenstad, Anne Marie; Hagen, Kåre Birger (Journal article; Peer reviewed, 2024)

  Objective: To assess the quality of care, effectiveness, and cost-effectiveness over 12 months after implementing a structured model of care for hip and knee osteoarthritis (OA) in primary healthcare as compared to usual ...

• The TP53 Codon 72 Arginine Polymorphism Is Found with Increased TP53 Somatic Mutations in HPV(−) and in an Increased Percentage among HPV(+) Norwegian HNSCC Patients 

  Moe, Svein Erik Emblem; Erland, Fredrik Atteraas; Fromreide, Siren; Lybak, Stein; Brydøy, Marianne; Dongre, Harsh Nitin; Manueldas, Sophia; Costea, Daniela Elena; Vintermyr, Olav Karsten; Aarstad, Hans Jørgen (Journal article; Peer reviewed, 2023-06-26)

  Background: Somatic TP53 mutations are frequent in head and neck squamous cell carcinoma (HNSCC) and are important pathogenic factors. Objective: To study TP53 mutations relative to the presence of human papillomavirus ...

• External validation of SAPS II score reported to the Norwegian Intensive Care and Pandemic Registry (NIPaR) 

  Buanes, Eirik Alnes; Bruserud, Øyvind; Carracedo Huroz, Sergio; Barratt-Due, Andreas; Flaatten, Hans Kristian; Kvåle, Reidar (Journal article; Peer reviewed, 2023)

  Background: Simplified Acute Physiology Score II (SAPS II) is a mortality prediction model widely used to compensate for differences between intensive care units (ICU) in benchmarking and research. Accuracy of SAPS II is ...

• Case Report: Limbic encephalitis following treatment with durvalumab for small-cell lung cancer 

  Moss, Thomas Totland; Stavem, Knut; Aandahl, Astrid; Gløersen, Anne S.; Grønberg, Bjørn Henning; Neumann, Kirill; Vedeler, Christian Alexander; Lundqvist, Christofer (Journal article; Peer reviewed, 2023-10-16)

  Background: Durvalumab is an immune checkpoint Inhibitor (ICIs) that is used in the treatment of malignant tumors, such as lung cancer and melanoma. ICIs are associated with immune-related adverse events including autoimmune ...

• TP53 mutation and human papilloma virus status as independent prognostic factors in a Norwegian cohort of vulva squamous cell carcinoma 

  Dongre, Harsh Nitin; Elnour, Rammah; Tornaas, Stian; Fromreide, Siren; Thomsen, Liv Cecilie Vestrheim; Kolseth, Ingrid Moss; Nginamau, Elisabeth Sivy; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Costea, Daniela Elena; Bjørge, Line (Journal article; Peer reviewed, 2024)

  Introduction: Vulva squamous cell carcinoma (VSCC) develops through two separate molecular pathways—one involving high-risk human papilloma virus infection (HPV-associated), and the other without HPV infection (HPV-independent) ...

• Specific neuropsychiatric symptoms are associated with functional decline trajectories in Alzheimer’s disease and Lewy body dementia: a five-year follow-up study 

  Borda, Miguel Germán; Brønnick, Kolbjørn Kallesten; Garcia-Cifuentes, Elkin; Jaramillo-Jiménez, Alberto; Reyes-Ortiz, Carlos; Patricio-Baldera, Jonathan; Sønnesyn, Hogne; Pérez-Zepeda, Mario Ulises; Vik-Mo, Audun Osland; Aarsland, Dag (Journal article; Peer reviewed, 2023-10-17)

  Background: Neuropsychiatric symptoms (NPS) are often overlooked and under-identified symptoms associated with dementia, despite their significant impact on the prognosis of individuals living with the disease. The specific ...

• A new pathway for penicillin delabeling in Norway 

  Alnæs, Marie Bjørbak; Oppegaard, Oddvar; Kittang, Bård Reiakvam; Lygre, Stein Håkon Låstad; Langeland, Anine Bernhoft; Skodvin, Brita; Bjånes, Tormod Karlsen; Storaas, Torgeir (Journal article; Peer reviewed, 2023)

  Background: Penicillin allergy is self-reported by 3–10% of patients admitted to hospital. The label is wrong in 90% of the cases and has severe health implications. Penicillin-delabeling can reverse the negative effects ...

• Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer 

  Børretzen, Astrid; Reisæter, Lars Anders Rokne; Ringheim, Anders; Gravdal, Karsten; Haukaas, Svein Andreas; Fasmer, Kristine Eldevik; Haldorsen, Ingfrid S.; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2023)

  Active angiogenesis may be assessed by immunohistochemistry using Nestin, a marker of newly formed vessels, combined with Ki67 for proliferating cells. Here, we studied microvascular proliferation by Nestin-Ki67 co-expression ...

• Orthopaedic surgeons' ability to detect pathologic hip fractures: review of 1484 fractures reported to the Norwegian Hip Fracture Register 

  Sund, Anders; Dybvik, Eva Hansen; Gjertsen, Jan-Erik (Journal article; Peer reviewed, 2023-11-04)

  Background: The proximal femur is the most common location of metastases in the appendicular skeleton. Data on pathologic hip fractures, however, are sparse despite it is the most frequently operated pathologic fracture. ...

• Cognitive assessment in the early stages of multiple sclerosis : the importance of screening and management of cognitive impairment 

  Skorve, Ellen Danielsen (Doctoral thesis, 2024-04-19)

  Bakgrunn: Kognitiv svekkelse er et vanlig symptom hos pasienter med multippel sklerose (MS), med potentielt stor innvirkning på livskvalitet, yrkesdeltagelse og sosialt liv. Dette kan oppstå i alle stadier og alle subtyper ...

• Use and non-use of antipsychotics and other psychotropic drugs in schizophrenia 

  Strømme, Maria Fagerbakke (Doctoral thesis, 2022-06-08)

  Background: Little is known about health-related outcomes for patients with schizophrenia when comparing periods with use and non-use of antipsychotic drugs in a real-life setting. Current evidence is also limited for the ...

• Validation of forearm fracture diagnoses in administrative patient registers 

  Omsland, Tone Kristin; Solberg, Lene Bergendal; Bjørnerem, Åshild Marit; Borgen, Tove Tveitan; Andreasen, Camilla; Wisløff, Torbjørn; Hagen, Gunhild; Basso, Trude; Gjertsen, Jan-Erik; Apalset, Ellen Margrete; Figved, Wender; Stutzer, Jens-Meinhard; Nissen, Frida Igland; Hansen, Ann Kristin; Joakimsen, Ragnar Martin; Figari, Elisa; Peel, Geoffrey; Rashid, Ali A.; Khoshkhabari, Jashar; Eriksen, Erik Fink; Nordsletten, Lars; Frihagen, Frede; Dahl, Cecilie (Journal article; Peer reviewed, 2023)

  Summary: The validity of forearm fracture diagnoses recorded in five Norwegian hospitals was investigated using image reports and medical records as gold standard. A relatively high completeness and correctness of the ...

• Neurofilament and Brain Atrophy and Their Association with Cognition in Multiple Sclerosis: A 10-Year Follow-Up Study 

  Bhan, Alok; Jacobsen, Cecilie; Dalen, Ingvild; Alves, Guido Werner; Bergsland, Niels; Myhr, Kjell-Morten; Zetterberg, Henrik; Zivadinov, Robert; Farbu, Elisabeth (Journal article; Peer reviewed, 2023)

  Introduction. Cognitive impairment is an important contributor to disability in multiple sclerosis (MS). Disconnection of neuronal circuits due to axonal injury is probably an important underlying mechanism for this ...

• COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study 

  Jacobsen, Kaya Kvarme; Børte, Sigrid; Laborie, Lene Bjerke; Kristiansen, Hege; Schäfer, Annette; Gundersen, Trude; Zayats, Tetyana; Winsvold, Bendik Kristoffer Slagsvold; Karen, Rosendahl; Martinsen, Amy; Skogholt, Anne Heidi; Brumpton, Ben Michael; Willer, Cristen J; Fors, Egil Andreas; Kristoffersen, Espen Saxhaug; Heuch, Ingrid; Mundal, Ingunn Pernille; Zwart, John Anker Henrik; Nielsen, Jonas B.; Storheim, Kjersti; Hagen, Knut; Nilsen, Kristian Bernhard; Hveem, Kristian; Fritsche, Lars G; Thomas, Laurent Francois; Pedersen, Linda Margareth; Gabrielsen, Maiken Elvestad; Lie, Marie U.; Stensland, Synne; Zhou, Wei (Journal article; Peer reviewed, 2024)

  Objective: Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30% of all total hip arthroplasties (THAs) in adults ...

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