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dc.contributor.authorKoziel, Joannaeng
dc.contributor.authorMydel, Piotr Mateuszeng
dc.contributor.authorPotempa, Janeng
dc.date.accessioned2015-03-10T15:17:16Z
dc.date.available2015-03-10T15:17:16Z
dc.date.issued2014-01eng
dc.identifier.issn1523-3774eng
dc.identifier.urihttp://hdl.handle.net/1956/9494
dc.description.abstractPorphyromonas gingivalis is a leading pathogen in chronic periodontitis, a disease process involving progressive destruction of the tissues that support the teeth. Recently, the organism has been reported to produce a unique bacterial enzyme, P. gingivalis peptidyl-arginine deiminase (PPAD), which has the ability to convert arginine residues in proteins to citrulline. Protein citrullination alters protein structure and function; hence, PPAD may be involved in deregulation of the host’s signalling network and immune evasion. Further, accumulating evidence suggests a role for autoimmunity against citrullinated proteins in the development of rheumatoid arthritis (RA). As inflammatory conditions in the lungs of cigarette smokers contribute to the breakdown of immune tolerance to citrullinated epitopes, chronic exposure to citrullinated proteins at periodontitis sites may also predispose susceptible individuals to the development of autoantibodies and the initiation of RA. In this review, we discuss evidence that PPAD may represent a mechanistic link between periodontitis and RA, diseases that are known to be significantly associated at the epidemiological level.en_US
dc.language.isoengeng
dc.publisherSpringereng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectPeriodontal diseaseeng
dc.subjectRheumatoid arthritiseng
dc.subjectCitrullinationeng
dc.subjectPPADeng
dc.subjectPeriodontitiseng
dc.subjectP. gingivalis peptidyl-arginine deiminase (PPAD)eng
dc.titleThe link between periodontal disease and rheumatoid arthritis: An updated revieweng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk odontologiske fag: 830::Periodonti: 837nob
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759nob
dc.subject.nsiVDP::Medical sciences: 700::Clinical dentistry sciences: 830::Periodontics: 837eng
dc.subject.nsiVDP::Medical sciences: 700::Clinical medical sciences: 750::Rheumatology: 759eng
dc.date.updated2015-03-05T09:17:17Zen_US
dc.rights.holderCopyright 2014 The Authors
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bora.journalTitleCurrent Rheumatology Reportseng
bibo.volume16eng
bibo.number408eng
bibo.doihttp://dx.doi.org/10.1007/s11926-014-0408-9eng
bora.accessRightsinfo:eu-repo/semantics/openAccesseng
dc.identifier.cristinID1156875eng
dc.identifier.doi10.1007/s11926-014-0408-9


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