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dc.contributor.authorMrdalj, Jelenaeng
dc.contributor.authorPallesen, Ståleeng
dc.contributor.authorMilde, Anne Maritaeng
dc.contributor.authorJellestad, Finn Konoweng
dc.contributor.authorMurison, Roberteng
dc.contributor.authorUrsin, Reiduneng
dc.contributor.authorBjorvatn, Bjørneng
dc.contributor.authorGrønli, Janneeng
dc.date.accessioned2015-03-17T12:30:30Z
dc.date.available2015-03-17T12:30:30Z
dc.date.issued2013-07-26eng
dc.identifier.issn1932-6203eng
dc.identifier.urihttp://hdl.handle.net/1956/9544
dc.description.abstractExposure to early life stress may profoundly influence the developing brain in lasting ways. Neuropsychiatric disorders associated with early life adversity may involve neural changes reflected in EEG power as a measure of brain activity and disturbed sleep. The main aim of the present study was for the first time to characterize possible changes in adult EEG power after postnatal maternal separation in rats. Furthermore, in the same animals, we investigated how EEG power and sleep architecture were affected after exposure to a chronic mild stress protocol. During postnatal day 2–14 male rats were exposed to either long maternal separation (180 min) or brief maternal separation (10 min). Long maternally separated offspring showed a sleep-wake nonspecific reduction in adult EEG power at the frontal EEG derivation compared to the brief maternally separated group. The quality of slow wave sleep differed as the long maternally separated group showed lower delta power in the frontal-frontal EEG and a slower reduction of the sleep pressure. Exposure to chronic mild stress led to a lower EEG power in both groups. Chronic exposure to mild stressors affected sleep differently in the two groups of maternal separation. Long maternally separated offspring showed more total sleep time, more episodes of rapid eye movement sleep and higher percentage of non-rapid eye movement episodes ending in rapid eye movement sleep compared to brief maternal separation. Chronic stress affected similarly other sleep parameters and flattened the sleep homeostasis curves in all offspring. The results confirm that early environmental conditions modulate the brain functioning in a long-lasting way.en_US
dc.language.isoengeng
dc.publisherPublic Library of Scienceeng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/9543" target="blank">The early life condition: Importance for sleep, circadian rhythmicity, behaviour and response to later life challenges</a>eng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/eng
dc.titleEarly and Later Life Stress Alter Brain Activity and Sleep in Ratseng
dc.typeJournal articleeng
dc.rights.holderCopyright: 2013 Mrdalj et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bora.journalTitlePLoS ONEeng
bibo.volume8eng
bibo.issue7eng
bibo.numbere69923eng
bibo.doihttp://dx.doi.org/10.1371/journal.pone.0069923eng
bora.accessRightsinfo:eu-repo/semantics/openAccesseng
dc.identifier.cristinID1041210eng
dc.identifier.doi10.1371/journal.pone.0069923
dcterms.isPartOfhttp://hdl.handle.net/1956/9543


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