Recent Submissions

  • Autoimmunity and viral immunity in Addison’s disease 

    Waade Edvardsen, Kine Susann (The University of Bergen, 2015-11-27)
    Autoimmune Addison’s disease (AAD) is caused by an immunological destruction of the steroid producing cells of the adrenal cortex. Both genetic and environmental factors are involved in disease development, and while ...
    Doctoral thesis
  • Diet in irritable bowel syndrome 

    El-Salhy, Magdy; Gundersen, Doris Irene (BioMed Central Ltd, 2015-04-14)
    Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder that is characterized by intermittent abdominal pain/discomfort, altered bowel habits and abdominal bloating/distension. This review aimed at ...
    Journal article
  • Longterm follow-up in European respiratory health studies - patterns and implications 

    Johannessen, Ane; Verlato, Guiseppe; Benediktsdottir, Bryndis; Forsberg, Bertil; Franklin, Karl; Gíslason, Thorainn; Holm, Mathias; Janson, Christer; Jögi, Rain; Lindberg, Eva; Macsali, Ferenc; Omenaas, Ernst; Gomez Real, Francisco; Saure, Eirunn Waatevik; Schlünssen, Vivi; Sigsgaard, Torben; Skorge, Trude Duelien; Svanes, Cecilie; Torén, Kjell; Waatevik, Marie Johanne; Nilsen, Roy Miodini; de Marco, Roberto (BioMed Central, 2014-04-16)
    Background: Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection ...
    Journal article
  • Dietary casein has a higher potential than cod and pork to induce weight loss in obese C57BL/6J mice 

    Søgnen, Mona (The University of Bergen, 2015-05-15)
    OBJECTIVE: In the western world, a high energy intake combined with limited physical activity have resulted in an obesity epidemic. Challenges associated with this is an altered glucose homeostasis, increased risk of several ...
    Master thesis
  • Combining a low fat diet with exercise reverses diet-induced obesity and improves glucose homeostasis in C57BL/6J mice 

    Andersen, Hanne (The University of Bergen, 2015-05-15)
    Background: The prevalence of obesity and obesity- related disorders, including type 2 diabetes and non-alcohol fatty liver disease is alarmingly high. These conditions can mostly be attributed to increased intake of energy ...
    Master thesis
  • Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor-resistant, low- and Int-1-risk MDS: Results from the nordic NMDSG08A phase II trial 

    Tobiasson, Magnus; Dybedal, Ingunn; Holm, Mette Skov; Karimi, Mohsen; Brandefors, Lena; Garelius, Hege; Grövdal, Michael; Høgh-Dufva, Inge; Grønbæk, Kirsten; Jansson, Monika; Marcher, Vlaus Werenberg; Nilsson, Lars Håkan; Kittang, Astrid Marta Olsnes; Porwit, Anna; Saft, Leonie; Möllgård, Lars; Hellström-Lindberg, Eva (Nature Publishing Group, 2014)
    This prospective phase II study evaluated the efficacy of azacitidine (Aza)+erythropoietin (Epo) in transfusion-dependent patients with lower-risk myelodysplastic syndrome (MDS). Patients ineligible for or refractory to ...
    Journal article
  • Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms 

    Andreassen, Ole Andreas; Desikan, Rahul S.; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Zuber, Verena; Doncheva, Nadezhda T.; Ellinghaus, E.va; Mattingsdal, Morten; Franke, Andre; Lie, Benedicte. A.; Mills, Ian Geoffrey; Aukrust, Pål; McEvoy, Linda K.; Djurovic, Srdjan; Karlsen, Tom H.; Dale, Anders M. (PLoS, 2015-04-08)
    Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well understood. We used genome-wide association studies (GWAS) to investigate ...
    Journal article
  • Prognostic impact of vitamin B6 metabolism in lung cancer 

    Galluzzi, Lorenzo; Vitale, Ilio; Senovilla, Laura; Olaussen, Ken André; Pinna, Guillaume; Eisenberg, Tobias; Goubar, Aïcha; Martins, Isabelle; Michels, Judith; Kratassiouk, Guerorgui; Carmona-Gutierrez, Didac; Scoazec, Marie; Vacchelli, Erika; Schlemmer, Frederic; Kepp, Oliver; Shen, Sheshi; Tailler, Maximilien; Niso-Santano, Mireia; Morselli, Eugenia; Criollo, Alfredo; Adjemian, Sandy; Jemaa, Mohamed; Chaba, Kariman; Pailleret, Claire; Michaud, Mickaël; Pietrocola, Federico; Tajeddine, Nicolas; Rouge, Thibault de La Motte; Araujo, Natalia; Morozova, Nadya; Robert, Thomas; Ripoche, Hugues; Commo, Frederic; Besse, Benjamin; Validire, Pierre; Fouret, Pierre; Robin, Angélique; Dorvault, Nicolas; Girard, Philippe; Gouy, Sébastien; Pautier, Patricia; Jägemann, Nora; Nickel, Ann-Christin; Marsili, Sabrina; Paccard, Caroline; Servant, Nicolas; Hupé, Philippe; Behrens, Carmen; Behnam-Motlagh, Paviz; Kohno, Kimitoshi; Cremer, Isabelle; Damotte, Diane; Alifano, Marco; Midttun, Øivind; Ueland, Per Magne; Lazar, Vladimir; Dessen, Philippe; Zischka, Hans; Chatelut, Etienne; Castedo, Maria; Madeo, Frank; Barillot, Emmanuel; Thomale, Jürgen; Wistuba, Ignacio Ivan; Sautes-Fridman, Catherine; Zitvogel, Laurence; Soria, Jean-Charles; Harel-Bellan, Annick; Kroemer, Guido (Elsevier, 2012-08-30)
    Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin ...
    Journal article
  • A salmon peptide diet alleviates experimental colitis as compared with fish oil 

    Grimstad, Tore; Bjørndal, Bodil; Cacabelos, Daniel; Aasprong, Ole Gunnar; Omdal, Roald; Svardal, Asbjørn M.; Bohov, Pavol; Pamplona, Reinald; Portero-Otin, Manuel; Berge, Rolf Kristian; Hausken, Trygve (Cambridge University Press, 2013-01-10)
    Fish oil (FO) has been shown to have anti-inflammatory properties in animal models of inflammatory bowel disease, but how fish peptides (FP) influence intestinal inflammation has been less studied. Male Wistar rats, divided ...
    Journal article
  • A question–answer pair (QAP) database integrated with websites to answer complex questions submitted to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive study 

    Schjøtt, Jan; Reppe, Linda Amundstuen; Roland, Pål-Didrik Hoff; Westergren, Tone (Elsevier, 2012-03-15)
    Objective To assess a question–answer pair (QAP) database integrated with websites developed for drug information centres to answer complex questions effectively. Design Descriptive study with comparison of two ...
    Journal article
  • Cost effectiveness of adding budesonide/formoterol to tiotropium in COPD in four Nordic countries 

    Nielsen, Rune; Kankaanranta, Hannu; Bjermer, Leif; Lange, Peter; Arnetorp, Sofie; Hedegaard, Morten; Stenling, Anna; Mittmann, Nicole (Elsevier, 2013-11)
    Objective: Assess the cost effectiveness of budesonide/formoterol (BUD/FORM) Turbuhaler®+tiotropium (TIO) HandiHaler® vs. placebo (PBO)+TIO in patients with chronic obstructive pulmonary disease (COPD) eligible for inhaled ...
    Journal article
  • Update on primary sclerosing cholangitis 

    Karlsen, Tom Hemming; Boberg, Kirsten Muri (Elsevier, 2013-09)
    Primary sclerosing cholangitis (PSC) remains one of the most challenging conditions of clinical hepatology. There has been a steady growth in research to overcome this fact and the present review aims at summarizing the ...
    Journal article
  • Investigation of complement component C4 copy number variation in human longevity 

    Flachsbart, Friederike; Caliebe, Amke; Heinsen, Femke-Anouska; Karlsen, Tom Hemming; Schreiber, Stefan; Franke, Andre; Nebel, Almut (PLoS, 2014-01-22)
    Genetic factors have been estimated to account for about 25% of the variation in an adult’s life span. The complement component C4 with the isotypes C4A and C4B is an effector protein of the immune system, and differences ...
    Journal article
  • Susceptibility to chronic mucus hypersecretion, a genome wide association study 

    Dijkstra, Akkelies E.; Smolonska, J; Van Den Berge, M; Wijmenga, C; Zanen, P; Luinge, MA; Platteel, M; Lammers, JW; Dahlback, M; Tosh, K; Hiemstra, PS; Sterk, PJ; Spira, A; Vestbo, J; Nordestgaard, BG; Benn, M; Nielsen, SF; Dahl, M; Verschuren, WM; Picavet, HSJ; Smit, HA; Owsijewitsch, M; Kauczor, HU; De Koning, HJ; Nizankowska-Mogilnicka, E; Mejza, F; Nastalek, P; Van Diemen, CC; Cho, MH; Silverman, EK; Crapo, JD; Beaty, TH; Lomas, DA; Bakke, Per; Gulsvik, Amund; Bosse, Y; Obeidat, MA; Loth, DW; Lahousse, L; Rivadeneira, F; Uitterlinden, AG; Hofman, A; Stricker, BH; Brusselle, GG; Van Duijn, CM; Brouwer, U; Koppelman, GH; Vonk, JM; Nawijn, MC; Groen, HJM; Timens, W; Boezen, HM; Postma, DS; Alizadeh, BZ; De Boer, RA; Bruinenberg, M; Franke, L; Van Der Harst, P; Hillege, HL; Van Der Klauw, MM; Navis, G; Ormel, J; Rosmalen, J; Slaets, JP; Snieder, H; Stolk, RP; Wolffenbuttel, B (PLoS, 2014-04-08)
    Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. ...
    Journal article
  • Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study 

    Mehl, Arne; Harthug, Stig; Lydersen, Stian; Paulsen, Julie; Åsvold, Bjørn Olav; Solligård, Erik; Damås, Jan Kristian; Edna, Tom-Harald (Springer, 2015-03)
    n several studies on patients with bloodstream infection (BSI), prior use of statins has been associated with improved survival. Gram-positive and Gram-negative bacteria alert the innate immune system in different ways. ...
    Journal article
  • Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome 

    Mazzawi, Tarek; Gundersen, Doris; Hausken, Trygve; El-Salhy, Magdy (Spandidos, 2014-11)
    The gut endocrine cells control and regulate several functions of the gastrointestinal tract. They have been reported to be abnormal in irritable bowel syndrome (IBS), with alterations occurring in several functions regulated ...
    Journal article
  • Development of functional gastrointestinal disorders after Giardia lamblia infection 

    Hanevik, Kurt; Dizdar, Vernesa; Langeland, Nina; Hausken, Trygve (BioMed Central, 2009-04-21)
    Background: Functional gastrointestinal disorders (FGID) may occur following acute gastroenteritis. This long-term complication has previously not been described after infection with the non-invasive protozoan Giardia ...
    Journal article
  • Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)alpha agonist fenofibrate and the PPAR gamma agonist pioglitazone 

    Syversen, Unni; Stunes, Astrid Kamilla; Gustafsson, Björn I.; Obrant, Karl J.; Nordsletten, Lars; Berge, Rolf K.; Thommesen, Liv; Reseland, Janne E. (BioMed Central, 2009-03-30)
    Background: All the peroxisome proliferator activated receptors (PPARs) are found to be expressed in bone cells. The PPARγ agonist rosiglitazone has been shown to decrease bone mass in mice and thiazolidinediones ...
    Journal article
  • Predictors of long time survival after lung cancer surgery. A retrospective cohort study. 

    Roth, Kjetil; Nilsen, Tom Ivar Lund; Hatlen, Elisabeth; Sørensen, Karina Søvik; Hole, Torstein; Haaverstad, Rune (BioMed Central, 2008-10-27)
    Background: There have been few reports regarding long time survival after lung cancer surgery. The influence of age and pulmonary function on long time survival is still not fully discovered. Some reports suggest that ...
    Journal article
  • Does a history of migraine affect the rate of thrombolysis in young stroke patients? 

    Øygarden, Halvor; Kvistad, Christopher Elnan; Thomassen, Lars; Waje-Andreassen, Ulrike; Næss, Halvor (Hindawi, 2013)
    Background. Migraine is prevalent in young patients and a frequent stroke mimic. To distinguish stroke mimics from true stroke can be difficult, and there is a possibility of misdiagnosing a stroke as a migrainous attack ...
    Journal article

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