Now showing items 21-30 of 220
Flt3 receptor tyrosine kinase in AML and its modulation of the p53/Hdm2/Bcl-2 pathway
(The University of Bergen, 2007-09-06)
Acute myeloid leukemia (AML) is an aggressive disease with a poor overall survival rate. The most frequent mutations associated with AML are internal tandem duplications (ITD) in the juxtamembrane region of the receptor ...
Prognostic indicators of total-, cardiac- and sudden cardiac death in chest pain patients with suspected acute coronary syndrome (ACS)
(The University of Bergen, 2013-05-30)
Radiofrequency ablation of atrial fibrillation. Clinical results and studies of mechanisms
(The University of Bergen, 2011-09-30)
Introduction: Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia. AF requires a trigger that initiates the arrhythmia, and the presence of a predisposing substrate that perpetuates it. ...
Predictive and Prognostic Impact of TP53 Mutations and MDM2 Promoter Genotype in Primary Breast Cancer Patients Treated with Epirubicin or Paclitaxel
(Public Library of Science, 2011-04-27)
Background: TP53 mutations have been associated with resistance to anthracyclines but not to taxanes in breast cancer patients. The MDM2 promoter single nucleotide polymorphism (SNP) T309G increases MDM2 activity and may ...
Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome
The gut endocrine cells control and regulate several functions of the gastrointestinal tract. They have been reported to be abnormal in irritable bowel syndrome (IBS), with alterations occurring in several functions regulated ...
Subjective food hypersensitivity: Studies on enterochromaffin cell secretion products and effects of seal oil therapy
(The University of Bergen, 2013-03-08)
Background: Perceived food hypersensitivity is a prevalent condition which often remains medically unexplained. The etiology of this subjective condition is not fully understood, mainly because of a lack of specific ...
Iron Status in Norwegian Blood Donors
(The University of Bergen, 2010-05-07)
Background and aims: Blood banks in Norway struggle to close the gap between need and supply of blood. The overall objective of this study was to investigate the iron status in blood donors. The aims of this thesis were ...
Biological mechanisms for chronic fatigue in primary Sjøgren`s syndrome
(The University of Bergen, 2012-06-15)
Background: Primary Sjøgren`s syndrome (pSS) is a chronic autoimmune disease, characterised by lymphocytic infiltration of exocrine glands and autoantibody production. Fatigue is a frequent phenomenon in pSS, associated ...
The role of dietary fat and carbohydrates in development of adipose tissue inflammation
(The University of Bergen, 2009-06-02)
Obesity is considered as a chronic low-grade inflammatory condition, which can be characterized by increased levels of the proinflammatory cytokines such as TNF-α and IL-6, and macrophage infiltration in adipose tissue. ...
Serum 25(OH)D Is a 2-Year Predictor of All-Cause Mortality, Cardiac Death and Sudden Cardiac Death in Chest Pain Patients from Northern Argentina
(Public Library of Science, 2012-09-06)
Background: Several studies have shown an association between vitamin D deficiency and cardiovascular risk. Vitamin D status is assessed by determination of 25-hydroxyvitamin D [25(OH)D] in serum. Methods: We assessed the ...