Now showing items 31-40 of 219
Autoimmune polyendocrine syndrome type I. Novel diagnostic assays and immune regulation
(The University of Bergen, 2012-02-10)
Autoimmune polyendocrine syndrome type I (APS-I) is a rare, monogenetic recessively inherited disease caused by mutations in the autoimmune regulator (AIRE) gene. The patients display different endocrine and ectodermal ...
Long-term prognosis in chronic primary glomerulonephritides
(The University of Bergen, 2012-03-15)
Chronic primary glomerulonephritides (CPGN) is a group of diseases characterised by leakage of proteins and/or erythrocytes into the urine with or without decreased glomerular filtration rate (GFR), hypertension, oedema, ...
Delineating cellular and molecular mechanisms of toxicity of an extract of khat (Catha edulis Forsk.) in leukemia and normal peripheral blood cells
(The University of Bergen, 2010-05-07)
Plants have been used in treatment and prevention of diseases for thousands of years. In modern medicine there is a trend towards isolation and identification of bioactive molecules, whereas plant preparations continue ...
High-intensity Interval Training after Percutaneous Coronary Intervention. A randomized controlled study evaluating the effect of exercise training on late luminal loss with relationship to inflammation and endothelial function
(The University of Bergen, 2010-10-22)
Introduction: In spite of consistent scientific documentation of the beneficial effects of exercise training programs in coronary artery disease (CAD), exercise training is a remarkably underutilized (1) and probably ...
Genetic biomarkers as prognostic and predictive factors in metastatic malignant melanoma
(The University of Bergen, 2010-10-26)
Malignant melanoma is one of the most chemoresistant malignancies in man. Although effort is put into developing new drugs to treat metastatic melanoma, still dacarbazine, an alkylating agent approved in 1975 for therapeutic ...
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response
(BioMed Central, 2010-03-25)
Background: Breast cancer is the most frequent cancer in women and consists of a heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic characteristics. In this study, we aimed to ...
Calprotectin (S100A8/A9) and S100A12 in inflammatory arthritis : clinical and epidemiological studies of rheumatoid and psoriatic arthritis
(The University of Bergen, 2007-12-14)
Rheumatoid- and psoriatic arthritis (RA and PsA) are the two most prevalent inflammatory joint diseases in Caucasian. Different biomarkers in peripheral blood may contribute in the diagnostic and prognostic process, as ...
Flt3 receptor tyrosine kinase in AML and its modulation of the p53/Hdm2/Bcl-2 pathway
(The University of Bergen, 2007-09-06)
Acute myeloid leukemia (AML) is an aggressive disease with a poor overall survival rate. The most frequent mutations associated with AML are internal tandem duplications (ITD) in the juxtamembrane region of the receptor ...
Prognostic indicators of total-, cardiac- and sudden cardiac death in chest pain patients with suspected acute coronary syndrome (ACS)
(The University of Bergen, 2013-05-30)
Radiofrequency ablation of atrial fibrillation. Clinical results and studies of mechanisms
(The University of Bergen, 2011-09-30)
Introduction: Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia. AF requires a trigger that initiates the arrhythmia, and the presence of a predisposing substrate that perpetuates it. ...