Now showing items 1-20 of 144

    • Autoimmunity and viral immunity in Addison’s disease 

      Waade Edvardsen, Kine Susann (The University of Bergen, 2015-11-27)
      Autoimmune Addison’s disease (AAD) is caused by an immunological destruction of the steroid producing cells of the adrenal cortex. Both genetic and environmental factors are involved in disease development, and while ...
      Doctoral thesis
    • Combining a low fat diet with exercise reverses diet-induced obesity and improves glucose homeostasis in C57BL/6J mice 

      Andersen, Hanne (The University of Bergen, 2015-05-15)
      Background: The prevalence of obesity and obesity- related disorders, including type 2 diabetes and non-alcohol fatty liver disease is alarmingly high. These conditions can mostly be attributed to increased intake of energy ...
      Master thesis
    • Dietary casein has a higher potential than cod and pork to induce weight loss in obese C57BL/6J mice 

      Søgnen, Mona (The University of Bergen, 2015-05-15)
      OBJECTIVE: In the western world, a high energy intake combined with limited physical activity have resulted in an obesity epidemic. Challenges associated with this is an altered glucose homeostasis, increased risk of several ...
      Master thesis
    • Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms 

      Andreassen, Ole Andreas; Desikan, Rahul S.; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Zuber, Verena; Doncheva, Nadezhda T.; Ellinghaus,; Mattingsdal, Morten; Franke, Andre; Lie, Benedicte. A.; Mills, Ian Geoffrey; Aukrust, Pål; McEvoy, Linda K.; Djurovic, Srdjan; Karlsen, Tom H.; Dale, Anders M. (PLoS, 2015-04-08)
      Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well understood. We used genome-wide association studies (GWAS) to investigate ...
      Journal article
    • Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study 

      Mehl, Arne; Harthug, Stig; Lydersen, Stian; Paulsen, Julie; Åsvold, Bjørn Olav; Solligård, Erik; Damås, Jan Kristian; Edna, Tom-Harald (Springer, 2015-03)
      n several studies on patients with bloodstream infection (BSI), prior use of statins has been associated with improved survival. Gram-positive and Gram-negative bacteria alert the innate immune system in different ways. ...
      Journal article
    • Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome 

      Mazzawi, Tarek; Gundersen, Doris; Hausken, Trygve; El-Salhy, Magdy (Spandidos, 2014-11)
      The gut endocrine cells control and regulate several functions of the gastrointestinal tract. They have been reported to be abnormal in irritable bowel syndrome (IBS), with alterations occurring in several functions regulated ...
      Journal article
    • Seafood Intake and Serum Levels of Polychlorinated Biphenyls in Mother and Child 

      Barnung, Runa Borgund (The University of Bergen, 2014-05-15)
      Background and objectives Seafood is considered a natural part of a healthy and balanced diet. Seafood is an excellent source of high quality protein, and contains many essential nutrients like omega-3 fatty acids, vitamin ...
      Master thesis
    • A high proportion of dietary casein attenuates the obesogenic effect of high-fat diets in C57BL/6J mice 

      Hasselberg, Astrid Elise (The University of Bergen, 2014-05-15)
      The obesity epidemic is on the rise, and currently represents the largest global health threat. Westernization and advances in food production have led to a contemporary diet comprised of 49 % energy from carbohydrates, ...
      Master thesis
    • Sosiale skilnadar i kostvanar blant ungdom i Sogn og Fjordane i perioden 1997 - 2009 

      Stokstad, Janette Moland (The University of Bergen, 2014-05-15)
      Social disparities in health follow a gradient through the whole population, the social gradient in health. People with higher education, better occupational status and income live on average longer lives and have ...
      Master thesis
    • Depresjon og andre subjektive helseplager hos pasientar med korsryggsmerter. Har inntak av sjømat og vitamin D-status noko betyding? 

      Krogenes, Marianne Leiknes (The University of Bergen, 2014-05-15)
      Background: Vitamin D is found in limited selections of food, among other fatty fish and fish liver, as well as fortified food such as margarine and milk. Other vitamin D sources are dietary supplements and sunlight. Low ...
      Master thesis
    • Dietary methylmercury accumulates in pancreas and reduces basal insulin secretion in mice 

      Midttun, Ina (The University of Bergen, 2014-05-15)
      Lifestyle diseases like obesity and type 2 diabetes are highly prevalent worldwide, and represent a major public health concern. A potential link between lifestyle diseases and methylmercury exposure have been proposed in ...
      Master thesis
    • Maternal Seafood Consumption and Serum Levels of p.p'-DDE and PCB-153 in Mother and Child 

      Sørli, Kaja (The University of Bergen, 2014-05-15)
      Background: While seafood is a natural part of a healthy and balanced diet, it may also contain some undesirable environmental contaminants such as persistent organic pollutants (POPs), which can have detrimental effects ...
      Master thesis
    • Case-control study of food intake, nausea and vomiting of pregnant women 

      Birkeland, Elisabeth Sofie (The University of Bergen, 2014-05-15)
      Background: Severe pregnancy induced nausea and vomiting, also known as Hyperemesis gravidarum (HG), can lead to significant reduced quality of life (QOL) and of food intake. Untreated this can potentially harm both mother ...
      Master thesis
    • Longterm follow-up in European respiratory health studies - patterns and implications 

      Johannessen, Ane; Verlato, Guiseppe; Benediktsdottir, Bryndis; Forsberg, Bertil; Franklin, Karl; Gíslason, Thorainn; Holm, Mathias; Janson, Christer; Jögi, Rain; Lindberg, Eva; Macsali, Ferenc; Omenaas, Ernst; Gomez Real, Francisco; Saure, Eirunn Waatevik; Schlünssen, Vivi; Sigsgaard, Torben; Skorge, Trude Duelien; Svanes, Cecilie; Torén, Kjell; Waatevik, Marie Johanne; Nilsen, Roy Miodini; de Marco, Roberto (BioMed Central, 2014-04-16)
      Background: Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection ...
      Journal article
    • Is total immunoglobulin E and atopic sensitization associated with food-related gastrointestinal complaints? 

      Vara, Ellen Johanne (The University of Bergen, 2014-04-08)
      Background: We have observed increased number of "IgE-armed" mast cells in duodenal mucosa of patients with food hypersensitivity, and therefore we wanted to explore whether serum total IgE levels and atopic sensitization ...
      Master thesis
    • Susceptibility to chronic mucus hypersecretion, a genome wide association study 

      Dijkstra, Akkelies E.; Smolonska, J; Van Den Berge, M; Wijmenga, C; Zanen, P; Luinge, MA; Platteel, M; Lammers, JW; Dahlback, M; Tosh, K; Hiemstra, PS; Sterk, PJ; Spira, A; Vestbo, J; Nordestgaard, BG; Benn, M; Nielsen, SF; Dahl, M; Verschuren, WM; Picavet, HSJ; Smit, HA; Owsijewitsch, M; Kauczor, HU; De Koning, HJ; Nizankowska-Mogilnicka, E; Mejza, F; Nastalek, P; Van Diemen, CC; Cho, MH; Silverman, EK; Crapo, JD; Beaty, TH; Lomas, DA; Bakke, Per; Gulsvik, Amund; Bosse, Y; Obeidat, MA; Loth, DW; Lahousse, L; Rivadeneira, F; Uitterlinden, AG; Hofman, A; Stricker, BH; Brusselle, GG; Van Duijn, CM; Brouwer, U; Koppelman, GH; Vonk, JM; Nawijn, MC; Groen, HJM; Timens, W; Boezen, HM; Postma, DS; Alizadeh, BZ; De Boer, RA; Bruinenberg, M; Franke, L; Van Der Harst, P; Hillege, HL; Van Der Klauw, MM; Navis, G; Ormel, J; Rosmalen, J; Slaets, JP; Snieder, H; Stolk, RP; Wolffenbuttel, B (PLoS, 2014-04-08)
      Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. ...
      Journal article
    • Investigation of complement component C4 copy number variation in human longevity 

      Flachsbart, Friederike; Caliebe, Amke; Heinsen, Femke-Anouska; Karlsen, Tom Hemming; Schreiber, Stefan; Franke, Andre; Nebel, Almut (PLoS, 2014-01-22)
      Genetic factors have been estimated to account for about 25% of the variation in an adult’s life span. The complement component C4 with the isotypes C4A and C4B is an effector protein of the immune system, and differences ...
      Journal article
    • Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor-resistant, low- and Int-1-risk MDS: Results from the nordic NMDSG08A phase II trial 

      Tobiasson, Magnus; Dybedal, Ingunn; Holm, Mette Skov; Karimi, Mohsen; Brandefors, Lena; Garelius, Hege; Grövdal, Michael; Høgh-Dufva, Inge; Grønbæk, Kirsten; Jansson, Monika; Marcher, Vlaus Werenberg; Nilsson, Lars Håkan; Kittang, Astrid Marta Olsnes; Porwit, Anna; Saft, Leonie; Möllgård, Lars; Hellström-Lindberg, Eva (Nature Publishing Group, 2014)
      This prospective phase II study evaluated the efficacy of azacitidine (Aza)+erythropoietin (Epo) in transfusion-dependent patients with lower-risk myelodysplastic syndrome (MDS). Patients ineligible for or refractory to ...
      Journal article
    • Cost effectiveness of adding budesonide/formoterol to tiotropium in COPD in four Nordic countries 

      Nielsen, Rune; Kankaanranta, Hannu; Bjermer, Leif; Lange, Peter; Arnetorp, Sofie; Hedegaard, Morten; Stenling, Anna; Mittmann, Nicole (Elsevier, 2013-11)
      Objective: Assess the cost effectiveness of budesonide/formoterol (BUD/FORM) Turbuhaler®+tiotropium (TIO) HandiHaler® vs. placebo (PBO)+TIO in patients with chronic obstructive pulmonary disease (COPD) eligible for inhaled ...
      Journal article
    • Dietary intake of n-3 long-chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: a prospective cohort study 

      Strand, Elin; Pedersen, Eva Kristine Ringdal; Svingen, Gard Frodahl Tveitevåg; Schartum-Hansen, Hall; Rebnord, Eirik Wilberg; Bjørndal, Bodil; Seifert, Reinhard; Bohov, Pavol; Meyer, Klaus; Hiltunen, J. Kalervo; Nordrehaug, Jan Erik; Nilsen, Dennis W. T.; Berge, Rolf K.; Nygård, Ottar (BioMed Central, 2013-10-08)
      Background: A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence ...
      Journal article