Browsing Section for Haematology by Author "Bredholt, Therese"
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines Bredholt, Therese; Dimba, Elizabeth A. O.; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell Ove; Tronstad, Karl Johan; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore (BioMed Central, 2009-11-13)Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ...Journal articlePeer reviewed
Delineating cellular and molecular mechanisms of toxicity of an extract of khat (Catha edulis Forsk.) in leukemia and normal peripheral blood cells Bredholt, Therese (The University of Bergen, 2010-05-07)Plants have been used in treatment and prevention of diseases for thousands of years. In modern medicine there is a trend towards isolation and identification of bioactive molecules, whereas plant preparations continue ...Doctoral thesis