dc.contributor.author | Mi, Fengling | en_US |
dc.contributor.author | Jiang, Guanglu | en_US |
dc.contributor.author | Du, Jian | en_US |
dc.contributor.author | Li, Liang | en_US |
dc.contributor.author | Yue, Wentao | en_US |
dc.contributor.author | Harries, Anthony D. | en_US |
dc.contributor.author | Hinderaker, Sven Gudmund | en_US |
dc.contributor.author | Lin, Yan | en_US |
dc.date.accessioned | 2015-04-15T08:50:56Z | |
dc.date.available | 2015-04-15T08:50:56Z | |
dc.date.issued | 2014-05-19 | eng |
dc.identifier.issn | 1654-9880 | |
dc.identifier.uri | https://hdl.handle.net/1956/9788 | |
dc.description.abstract | Background: China has a high burden of drug-resistant tuberculosis (TB) and diabetes mellitus (DM). Objective: The objectives of this study were to determine the following in patients with culture-confirmed TB: 1) demographic characteristics and disease patterns in relation to the presence or absence of type 2 diabetes and 2) presence or absence of drug resistance to isoniazid (INH), rifampicin (RMP) or both in relation to duration of diabetes and control of diabetes. Design: This is a cross-sectional and retrospective study involving record reviews. Results: There were 621 patients with culture-positive TB, of whom 187 (30%) had previously known or new type 2 diabetes. In those with diabetes, there was a significantly higher proportion of males, persons aged ≥35 years and patients registered with new TB (p<0.05). Prevalence of multidrug-resistant TB (MDR-TB) was 6.2% in new patients (N=422) and 62.3% in previously treated patients (N=199), with no significant differences between those with and without diabetes. In patients with diabetes, there was no association of drug resistance with diabetes duration or disease control [assessed by fasting blood glucose (FBG) at 1 week]. Conclusion: A high proportion of patients with TB in a tertiary health facility, Beijing, China, had diabetes, but there was no association between type 2 diabetes and drug-resistant TB. Further prospective studies are needed to confirm these findings. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Co-Action Publishing | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject | Diabetes mellitus | eng |
dc.subject | diabetes duration | eng |
dc.subject | diabetes control | eng |
dc.subject | Tuberculosis | eng |
dc.subject | multidrug-resistant tuberculosis | eng |
dc.subject | China | eng |
dc.title | Is resistance to anti-tuberculosis drugs associated with type 2 diabetes mellitus? A register review in Beijing, China | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-04-01T09:51:28Z | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2014 Fengling Mi et al. | |
dc.source.articlenumber | 24022 | |
dc.identifier.doi | https://doi.org/10.3402/gha.v7.24022 | |
dc.identifier.cristin | 1162916 | |
dc.source.journal | Global health action | |
dc.source.40 | 7 | |
dc.subject.nsi | VDP::Medical sciences: 700::Clinical medical sciences: 750::Endocrinology: 774 | eng |
dc.subject.nsi | VDP::Medical sciences: 700::Basic medical, dental and veterinary sciences: 710::Clinical pharmacology: 739 | eng |
dc.subject.nsi | VDP::Medical sciences: 700::Clinical medical sciences: 750::Lung diseases: 777 | eng |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 | nob |
dc.subject.nsi | VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Klinisk farmakologi: 739 | nob |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Lungesykdommer: 777 | nob |