Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study
dc.contributor.author | Husebø, Gunnar Reksten | en_US |
dc.contributor.author | Bakke, Per | en_US |
dc.contributor.author | Aanerud, Marianne | en_US |
dc.contributor.author | Hardie, Jon Andrew | en_US |
dc.contributor.author | Ueland, Thor | en_US |
dc.contributor.author | Grønseth, Rune | en_US |
dc.contributor.author | Persson, Louise Jeanette Pauline | en_US |
dc.contributor.author | Aukrust, Pål | en_US |
dc.contributor.author | Eagan, Tomas Mikal | en_US |
dc.date.accessioned | 2015-04-15T11:48:15Z | |
dc.date.available | 2015-04-15T11:48:15Z | |
dc.date.issued | 2014-10-03 | eng |
dc.Published | 2014, 9: | en_US |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/1956/9799 | |
dc.description.abstract | Background: COPD exacerbations accelerate disease progression. Aims To examine if COPD characteristics and systemic inflammatory markers predict the risk for acute COPD exacerbation (AECOPD) frequency and duration. Methods: 403 COPD patients, GOLD stage II-IV, aged 44–76 years were included in the Bergen COPD Cohort Study in 2006/07, and followed for 3 years. Examined baseline predictors were sex, age, body composition, smoking, AECOPD the last year, GOLD stage, Charlson comorbidity score (CCS), hypoxemia (PaO2<8 kPa), cough, use of inhaled steroids, and the inflammatory markers leucocytes, C-reactive protein (CRP), neutrophil gelatinase associated lipocalin (NGAL), soluble tumor necrosis factor receptor 1 (sTNF-R1), and osteoprotegrin (OPG). Negative binomial models with random effects were fitted to estimate the annual incidence rate ratios (IRR). For analysis of AECOPD duration, a generalized estimation equation logistic regression model was fitted, also adjusting for season, time since inclusion and AECOPD severity. Results: After multivariate adjustment, significant predictors of AECOPD were: female sex [IRR 1.45 (1.14–1.84)], age per 10 year increase [1.23 (1.03–1.47)], >1 AECOPD last year before baseline [1.65 (1.24–2.21)], GOLD III [1.36 (1.07–1.74)], GOLD IV [2.90 (1.98–4.25)], chronic cough [1.64 (1.30–2.06)] and use of inhaled steroids [1.57 (1.21–2.05)]. For AECOPD duration more than three weeks, significant predictors after adjustment were: hypoxemia [0.60 (0.39–0.92)], years since inclusion [1.19 (1.03–1.37)], AECOPD severity; moderate [OR 1.58 (1.14–2.18)] and severe [2.34 (1.58–3.49)], season; winter [1.51 (1.08–2.12)], spring [1.45 (1.02–2.05)] and sTNF-R1 per SD increase [1.16 (1.00–1.35)]. Conclusion: Several COPD characteristics were independent predictors of both AECOPD frequency and duration. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Public Library of Science | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.title | Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-04-01T06:36:02Z | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright: 2014 Husebø et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.source.articlenumber | e0109721 | |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0109721 | |
dc.identifier.cristin | 1232735 | |
dc.source.journal | PLoS ONE | |
dc.source.40 | 9 | |
dc.subject.nsi | VDP::Medical sciences: 700::Clinical medical sciences: 750::Lung diseases: 777 | eng |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Lungesykdommer: 777 | nob |
dc.identifier.citation | PLoS ONE. 2014, 9 (10), e109721. |