Amelioration of Severe TNBS Induced Colitis by Novel AP-1 and NF-κB Inhibitors in Rats
dc.contributor.author | El-Salhy, Magdy | en_US |
dc.contributor.author | Umezawa, Kazuo | en_US |
dc.contributor.author | Gilja, Odd Helge | en_US |
dc.contributor.author | Hatlebakk, Jan G | en_US |
dc.contributor.author | Gundersen, Doris Irene | en_US |
dc.contributor.author | Hausken, Trygve | en_US |
dc.date.accessioned | 2015-05-15T12:59:35Z | |
dc.date.available | 2015-05-15T12:59:35Z | |
dc.date.issued | 2014-01-30 | eng |
dc.identifier.issn | 1537-744X | |
dc.identifier.uri | https://hdl.handle.net/1956/9888 | |
dc.description.abstract | AP-1 and NF-κB inhibitors, namely, DTCM-G and DHMEQ, were investigated in male Wistar rats with severe colitis, induced by TNBS. The animals were randomized into 3 groups. The control group received 0.5 mL of 0.5% of the vehicle i.p., the DTCM-G group received 22.5 mg/kg body weight DTCM-G in 0.5% i.p., and the DHMEQ group received 15 mg/kg body weight DHMEQ i.p., all twice daily for 5 days. The body weight losses and mortality rates were significantly higher in the control group than those in DTCM-G-treated and DHMEQ-treated groups. The endoscopic inflammation scores in the control, DTCM-G-treated, and DHMEQ-treated groups were 6.3 ± 0.7, 1.0 ± 0.3, and 0.7 ± 0.3, respectively (P = 0.004 and 0.02, resp.). The inflammation scores as assessed by the macroscopic appearance were 4.3 ± 0.8, 0.7 ± 0.3, and 1.2 ± 0.4 in the control, DTCM-G-treated, and DHMEQ-treated groups, respectively (P = 0.01 and 0.009, resp.). The histopathological inflammation scores were 6.4 ± 0.7, 2.0 ± 1.0, and 2.2 ± 0.6 in the control, DTCM-G-treated, and DHMEQ-treated groups, respectively (P = 0.03 and 0.01, resp.). It was concluded that DTCM-G and DHMEQ exhibit strong anti-inflammatory and anticancer activities with no apparent toxicity, which make them excellent drug candidates for clinical use in inflammatory bowel diseases. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Hindawi | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | eng |
dc.title | Amelioration of Severe TNBS Induced Colitis by Novel AP-1 and NF-κB Inhibitors in Rats | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-04-08T12:21:36Z | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2014 Magdy El-Salhy et al. | |
dc.source.articlenumber | 813804 | |
dc.identifier.doi | https://doi.org/10.1155/2014/813804 | |
dc.identifier.cristin | 1104572 | |
dc.source.journal | Scientific World Journal | |
dc.source.40 | 2014 | |
dc.subject.nsi | VDP::Medical sciences: 700::Clinical medical sciences: 750::Gastroenterology: 773 | eng |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773 | nob |