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dc.contributor.authorHill, Wayne Daviden_US
dc.contributor.authorDavies, Gailen_US
dc.contributor.authorVan De Lagemaat, Louie N.en_US
dc.contributor.authorChristoforou, Andreaen_US
dc.contributor.authorMarioni, Riccardo R.en_US
dc.contributor.authorDuarte Fernandes, Carlaen_US
dc.contributor.authorLiewald, David Cherryen_US
dc.contributor.authorCroning, Mike D.R.en_US
dc.contributor.authorPayton, Anthonyen_US
dc.contributor.authorCraig, Leone C.A.en_US
dc.contributor.authorWhalley, Lawrence J.en_US
dc.contributor.authorHoran, Michaelen_US
dc.contributor.authorOllier, William E.R.en_US
dc.contributor.authorHansell, Narelle K.en_US
dc.contributor.authorWright, Margaret J.en_US
dc.contributor.authorMartin, Nicholas G.en_US
dc.contributor.authorMontgomery, Grant W.en_US
dc.contributor.authorSteen, Vidar Martinen_US
dc.contributor.authorLe Hellard, Stephanieen_US
dc.contributor.authorEspeseth, Thomasen_US
dc.contributor.authorLundervold, Astrien_US
dc.contributor.authorReinvang, Ivaren_US
dc.contributor.authorStarr, John M.en_US
dc.contributor.authorPendleton, Neilen_US
dc.contributor.authorGrant, Seth G.N.en_US
dc.contributor.authorBates, Timothy C.en_US
dc.contributor.authorDeary, Ian Johnen_US
dc.date.accessioned2015-05-19T12:26:23Z
dc.date.available2015-05-19T12:26:23Z
dc.date.issued2014eng
dc.identifier.issn2158-3188
dc.identifier.urihttps://hdl.handle.net/1956/9897
dc.description.abstractDifferences in general cognitive ability (intelligence) account for approximately half of the variation in any large battery of cognitive tests and are predictive of important life events including health. Genome-wide analyses of common single-nucleotide polymorphisms indicate that they jointly tag between a quarter and a half of the variance in intelligence. However, no single polymorphism has been reliably associated with variation in intelligence. It remains possible that these many small effects might be aggregated in networks of functionally linked genes. Here, we tested a network of 1461 genes in the postsynaptic density and associated complexes for an enriched association with intelligence. These were ascertained in 3511 individuals (the Cognitive Ageing Genetics in England and Scotland (CAGES) consortium) phenotyped for general cognitive ability, fluid cognitive ability, crystallised cognitive ability, memory and speed of processing. By analysing the results of a genome wide association study (GWAS) using Gene Set Enrichment Analysis, a significant enrichment was found for fluid cognitive ability for the proteins found in the complexes of N-methyl-D-aspartate receptor complex; P=0.002. Replication was sought in two additional cohorts (N=670 and 2062). A meta-analytic P-value of 0.003 was found when these were combined with the CAGES consortium. The results suggest that genetic variation in the macromolecular machines formed by membrane-associated guanylate kinase (MAGUK) scaffold proteins and their interaction partners contributes to variation in intelligence.en_US
dc.language.isoengeng
dc.publisherNature Publishing Groupeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/eng
dc.subjectGWASeng
dc.subjectintelligenceeng
dc.subjectNMDA-RCeng
dc.subjectpathway analysiseng
dc.subjectsynapseeng
dc.titleHuman cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteinsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-04-08T09:57:18Zen_US
dc.description.versionpublishedVersionen_US
dc.source.articlenumbere341
dc.identifier.doihttps://doi.org/10.1038/tp.2013.114
dc.identifier.cristin1160927
dc.source.journalTranslational psychiatry
dc.source.404
dc.subject.nsiVDP::Social sciences: 200::Psychology: 260::Cognitive psychology: 267eng
dc.subject.nsiVDP::Medical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical genetics: 714eng
dc.subject.nsiVDP::Samfunnsvitenskap: 200::Psykologi: 260::Kognitiv psykologi: 267nob
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714nob


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