• Quality of Life in European Patients with Addison’s Disease: Validity of the Disease-Specific Questionnaire AddiQoL 

      Øksnes, Marianne; Bensing, Sophie; Hulting, Anna-Lena; Kämpe, Olle; Hackemann, Annika; Meyer, Gesine; Badenhoop, Klaus; Betterle, Corrado; Parolo, Anna; Giordano, Roberta; Falorni, Alberto; Papierska, Lucyna; Jeske, Wojciech; Kasperlik-Zaluska, Anna A.; Chatterjee, V. Krishna K.; Husebye, Eystein Sverre; Løvås, Kristian (Peer reviewed; Journal article, 2012-02)
      Context: Patients with Addison’s disease (AD) self-report impairment in specific dimensions on well-being questionnaires. An AD-specific quality-of-life questionnaire (AddiQoL) was developed to aid evaluation of patients. ...
    • Residual Corticosteroid Production in Autoimmune Addison Disease 

      Sævik, Åse Bjorvatn; Åkerman, Anna-Karin; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Høybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Valland, Susanna Fonneland; Wahlberg, Jeanette; Holte, Synnøve Emblem; Simunkova, Katerina; Kämpe, Olle; Husebye, Eystein Sverre; Bensing, Sophie; Øksnes, Marianne (Journal article; Peer reviewed, 2020)
      Design: Two-staged, cross-sectional clinical study in 17 centers (Norway, Sweden, and Germany). Residual glucocorticoid (GC) production was defined as quantifiable serum cortisol and 11-deoxycortisol and residual ...
    • Self-management and hospitalization in 615 Swedish patients with Addison's disease during the coronavirus disease 2019 pandemic: a retrospective study 

      Öster, Sara; Esposito, Daniela; Aranda-Guillén, Maribel; Åkerman, Anna-Karin; Wahlberg, Jeanette; Husebye, Eystein Sverre; Kämpe, Olle; Botusan, Ileana Ruxandra; Dahlqvist, Per; Bergthorsdottir, Ragnhildur; Bensing, Sophie (Journal article; Peer reviewed, 2023)
      Objective Autoimmune Addison's disease (AAD) entails a chronic adrenal insufficiency and is associated with an increased risk of severe infections. It is, however, unknown how patients with AAD were affected by the ...
    • Sex-Specific Limitations in Physical Health in Primary Adrenal Insufficiency 

      Didriksen, Nora Møller; Sævik, Åse Bjorvatn; Sortland, Linn Solveig; Øksnes, Marianne; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2021)
      Background: Patients with primary adrenal insufficiency (PAI) suffer reduced quality of life (QoL), but comparisons with large-scale normative data are scarce. The clinical characteristics associated with reduced QoL are ...
    • Substantial changes in inflammatory and cardiovascular biomarkers in patients with autonomous cortisol secretion 

      Ueland, Grethe Åstrøm; Methlie, Paal; Heie, Anette; Stokland, Ann-Elin Meling; Dahle, Anne Lise; Sævik, Åse Bjorvatn; Løvås, Kristian; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2023)
      Objective To map inflammatory biomarkers in patients with autonomous cortisol secretion (ACS) and overt Cushing syndrome (CS). Method Observational study including serum from prospectively included patients with ACS ...
    • Systemic Activation of the Kynurenine Pathway in Graves Disease With and Without Ophthalmopathy 

      Ueland, Hans Olav; Ulvik, Arve; Løvås, Kristian; Wolff, Anette Susanne Bøe; Breivik, Lars Ertesvåg; Stokland, Ann-Elin Meling; Rødahl, Eyvind; Nilsen, Roy Miodini; Husebye, Eystein Sverre; Ueland, Grethe Åstrøm (Journal article; Peer reviewed, 2023)
      Context Graves disease (GD) is one of the most common autoimmune disorders. Recent literature has shown an immune response involving several different inflammatory related proteins in these patients. Objective This ...
    • Systemic interferon type I and B cell responses are impaired in autoimmune polyendocrine syndrome type 1 

      Oftedal, Bergithe Eikeland; Delaleu, Nicolas; Dolan, David William Peter; Meager, Anthony; Husebye, Eystein Sverre; Wolff, Anette Susanne Bøe (Journal article; Peer reviewed, 2023)
      Autoimmune polyendocrine syndrome type I (APS-1) is caused by mutations in the autoimmune regulator (AIRE) gene and characterised clinically by multiple autoimmune manifestations and serologically by autoantibodies against ...
    • Therapy options for adrenal insufficiency and recommendations for the management of adrenal crisis 

      Nowotny, Hanna; Ahmed, S. Faisal; Bensing, Sophie; Beun, Johan G.; Brösamle, Manuela; Chifu, Irina; Claahsen van der Grinten, Hedi; Clemente, Maria; Falhammar, Henrik; Hahner, Stefanie; Husebye, Eystein Sverre; Kristensen, Jette; Loli, Paola; Lajic, Svetlana; Reisch, Nicole (Journal article; Peer reviewed, 2021)
      Adrenal insufficiency (AI) is a life-threatening condition requiring life-long glucocorticoid (GC) substitution therapy, as well as stress adaptation to prevent adrenal crises. The number of individuals with primary and ...
    • Transcriptional Changes in Regulatory T Cells From Patients With Autoimmune Polyendocrine Syndrome Type 1 Suggest Functional Impairment of Lipid Metabolism and Gut Homing 

      Berger, Amund Holte; Bratland, Eirik; Sjøgren, Thea; Heimli, Marte; Tyssedal, Torgeir; Bruserud, Øyvind; Johansson, Stefan; Husebye, Eystein Sverre; Oftedal, Bergithe Eikeland; Wolff, Anette Susanne Bøe (Journal article; Peer reviewed, 2021)
      Autoimmune polyendocrine syndrome type I (APS-1) is a monogenic model disorder of organ-specific autoimmunity caused by mutations in the Autoimmune regulator (AIRE) gene. AIRE facilitates the expression of organ-specific ...
    • Vaccination prevents severe COVID-19 outcome in patients with neutralizing type 1 interferon autoantibodies 

      Wolff, Anette Susanne Bøe; Hansen, Lena; Grytaas, Marianne Aardal; Oftedal, Bergithe Eikeland; Breivik, Lars Ertesvåg; Zhou, Fan; Hufthammer, Karl Ove; Sjøgren, Thea; Olofsson, Jan Stefan; Trieu, Mai Chi; Meager, Anthony; Jørgensen, Anders Palmstrøm; Lima, Kari; Mohn, Kristin Greve-Isdahl; Langeland, Nina; Cox Brokstad, Rebecca Jane; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2023)
      A hallmark of patients with autoimmune polyendocrine syndrome type 1 (APS-1) is serological neutralizing autoantibodies against type 1 interferons (IFN-I). The presence of these antibodies has been associated with severe ...