• The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease 

      Brakedal, Brage; Dölle, Christian; Riemer, Frank; Ma, Yilong; Nido, Gonzalo Sanchez; Skeie, Geir Olve; Craven, Alexander R.; Schwarzlmüller, Thomas; Brekke, Njål; Diab, Joseph; Sverkeli, Lars Jansen; Skjeie, Vivian; Varhaug, Kristin Nielsen; Tysnes, Ole-Bjørn; Peng, Shichun; Haugarvoll, Kristoffer; Ziegler, Mathias; Grüner, Renate; Eidelberg, David; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)
      We conducted a double-blinded phase I clinical trial to establish whether nicotinamide adenine dinucleotide (NAD) replenishment therapy, via oral intake of nicotinamide riboside (NR), is safe, augments cerebral NAD levels, ...
    • Negative valence of hallucinatory voices as predictor of cortical glutamatergic metabolite levels in schizophrenia patients 

      Hjelmervik, Helene; Craven, Alexander R.; Johnsen, Erik; Kompus, Kristiina; Bless, Josef Johann; Sinkeviciute, Igne; Kroken, Rune Andreas; Løberg, Else-Marie; Ersland, Lars; Grüner, Eli Renate; Sommer, Iris E.; Hugdahl, Kenneth Jan (Journal article; Peer reviewed, 2021)
      Objectives Negative emotional valence of auditory verbal hallucinations (AVHs) in schizophrenia can be a source of distress and is considered a strong predictor of illness severity. Previous studies have found glutamate ...
    • Neural activation in the ventromedial prefrontal cortex precedes conscious experience of being in or out of a transient hallucinatory state 

      Hugdahl, Kenneth; Craven, Alexander R.; Johnsen, Erik; Ersland, Lars; Stoyanov, Drozdstoy; Kandilarova, Sevdalina; Sandøy, Lydia Brunvoll; Kroken, Rune A.; Løberg, Else-Marie; Sommer, Iris E. (Journal article; Peer reviewed, 2022)
      Background and Hypotheses Auditory verbal hallucinations (AVHs) is not only a common symptom in schizophrenia but also observed in individuals in the general population. Despite extensive research, AVHs are poorly understood, ...
    • Neurobiological mechanisms of ECT and TMS treatment in depression: study protocol of a multimodal magnetic resonance investigation 

      Frid, Leila Marie; Kessler, Ute; Ousdal, Olga Therese; Hammar, Åsa Karin; Haavik, Jan; Riemer, Frank; Hirnstein, Marco; Ersland, Lars; Erchinger, Vera Jane; Ronold, Eivind Haga; Nygaard, Gyrid; Jakobsen, Petter; Craven, Alexander R.; Osnes, Berge; Alisauskiene, Renata; Bartsch, Hauke; Hellard, Stephanie Francoise Claire Le; Stavrum, Anne-Kristin Støbakk; Oedegaard, Ketil J.; Oltedal, Leif (Journal article; Peer reviewed, 2023)
      Background: Noninvasive neurostimulation treatments are increasingly being used to treat major depression, which is a common cause of disability worldwide. While electroconvulsive therapy (ECT) and transcranial magnetic ...
    • No Effects of Anodal tDCS on Local GABA and Glx Levels in the Left Posterior Superior Temporal Gyrus 

      Dwyer, Gerard Eric; Craven, Alexander R.; Hirnstein, Marco; Kompus, Kristiina; Assmus, Jörg; Ersland, Lars; Hugdahl, Kenneth; Grüner, Renate (Peer reviewed; Journal article, 2019-01-08)
      A number of studies investigating the biological effects of transcranial direct current stimulation (tDCS) using magnetic resonance spectroscopy (MRS) have found that it may affect local levels of γ-aminobutyric acid (GABA), ...
    • Pilot-RCT Finds No Evidence for Modulation of Neuronal Networks of Auditory Hallucinations by Transcranial Direct Current Stimulation 

      Marquardt, Lynn Anne; Craven, Alexander R.; Hugdahl, Kenneth Jan; Johnsen, Erik; Kroken, Rune Andreas; Kusztrits, Isabella; Specht, Karsten; Thomassen, Anne Synnøve; Weber, Sarah; Hirnstein, Marco (Journal article; Peer reviewed, 2022-10-12)
      Background: Transcranial direct current stimulation (tDCS) is used as treatment for auditory verbal hallucinations (AVH). The theory behind the treatment is that tDCS increases activity in prefrontal cognitive control ...
    • Similarities and differences between intermittent and continuous resting-state fMRI 

      Beresniewicz, Justyna; Riemer, Frank; Kazimierczak, Katarzyna Anna; Ersland, Lars; Craven, Alexander R.; Hugdahl, Kenneth Jan; Grüner, Renate (Journal article; Peer reviewed, 2023)
      Introduction: Functional Magnetic Resonance Imaging (fMRI) block-design experiments typically include active ON-blocks with presentation of cognitive tasks which are contrasted with OFF- blocks with no tasks presented. ...
    • Simultaneous Measurement of the BOLD Effect and Metabolic Changes in Response to Visual Stimulation Using the MEGA-PRESS Sequence at 3 T 

      Dwyer, Gerard Eric; Craven, Alexander R.; Beresniewicz, Justyna; Kazimierczak, Katarzyna Anna; Ersland, Lars; Hugdahl, Kenneth Jan; Grüner, Eli Renate (Journal article; Peer reviewed, 2021)
      The blood oxygen level dependent (BOLD) effect that provides the contrast in functional magnetic resonance imaging (fMRI) has been demonstrated to affect the linewidth of spectral peaks as measured with magnetic resonance ...
    • White matter microstructural differences between hallucinating and non-hallucinating schizophrenia spectrum patients 

      Beresniewicz, Justyna; Craven, Alexander R.; Hugdahl, Kenneth; Løberg, Else-Marie; Kroken, Rune Andreas; Johnsen, Erik; Gruner, Eli Renate (Journal article; Peer reviewed, 2021)
      The relation between auditory verbal hallucinations (AVH) and white matter has been studied, but results are still inconsistent. This inconsistency may be related to having only a single time-point of AVH assessment in ...