Blar i Bergen Open Research Archive på forfatter "Hertz, Daniel Louis"
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Effect of genetic variability in 20 pharmacogenes on concentrations of tamoxifen and its metabolites
Chen, Yuanhuang; Marcath, Lauren A.; Eliassen, Finn Magnus; Lende, Tone Hoel; Soiland, Havard; Mellgren, Gunnar; Helland, Thomas; Hertz, Daniel Louis (Journal article; Peer reviewed, 2021)Background: Tamoxifen, as a treatment of estrogen receptor positive (ER+) breast cancer, is a weak anti-estrogen that requires metabolic activation to form metabolites with higher anti-estrogenic activity. Endoxifen is the ... -
Generating a Precision Endoxifen Prediction Algorithm to Advance Personalized Tamoxifen Treatment in Patients with Breast Cancer
Helland, Thomas; Alsomairy, Sarah; Lin, Chenchia; Søiland, Håvard; Mellgren, Gunnar; Hertz, Daniel Louis (Journal article; Peer reviewed, 2021)Tamoxifen is an endocrine treatment for hormone receptor positive breast cancer. The effectiveness of tamoxifen may be compromised in patients with metabolic resistance, who have insufficient metabolic generation of the ... -
Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen
Helland, Thomas; Naume, Bjørn; Hustad, Steinar; Bifulco, Ersilia; Kvaløy, Jan Terje; Sætersdal, Anna Barbro; Synnestvedt, Marit; Lende, Tone Hoel; Gilje, Bjørnar; Mjaaland, Ingvil; Weyde, Kjetil; Blix, Egil Støre; Wiedswang, Gro; Borgen, Elin; Hertz, Daniel Louis; Janssen, Emiel; Mellgren, Gunnar; Søiland, Håvard (Journal article; Peer reviewed, 2021)Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant ...