Browsing Bergen Open Research Archive by Author "Davies, Richard Allan"
Now showing items 1-8 of 8
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Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation
Sarkar, Irene; Davies, Richard Allan; Aarebrot, Anders Krogh; Solberg, Silje Michelsen; Petrovic, Aleksandra; Joshi, Anagha; Bergum, Brith; Brun, Johan Gorgas; Hammenfors, Daniel; Jonsson, Roland; Appel, Silke (Journal article; Peer reviewed, 2022)Background: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, characterized by mononuclear cell infiltrates in the salivary and lacrimal glands, leading to glandular atrophy and dryness. Patient heterogeneity ... -
Flow cytometry based analyses as a tool in biomarker discovery for patient stratification in primary Sjögren’s syndrome
Davies, Richard Allan (Doctoral thesis, 2017-03-09)Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by lymphocytic infiltrates of exocrine glands, notably the salivary and lacrimal glands combined with immune-mediated glandular destruction. ... -
Harmonization and qualification of an IFN-γ Enzyme-Linked ImmunoSpot assay (ELISPOT) to measure influenza-specific cell-mediated immunity within the FLUCOP consortium
Waerlop, Gwenn; Leroux-Roels, Geert; Lambe, Teresa; Bellamy, Duncan; Medaglini, Donata; Pettini, Elena; Cox, Rebecca Jane; Trieu, Mai Chi; Davies, Richard Allan; Bredholt, Geir; Montomoli, Emanuele; Gianchecchi, Elena; Clement, Frédéric (Journal article; Peer reviewed, 2022-09-08)Influenza continues to be the most important cause of viral respiratory disease, despite the availability of vaccines. Today’s evaluation of influenza vaccines mainly focuses on the quantitative and functional analyses of ... -
Harmonization and qualification of intracellular cytokine staining to measure influenza-specific CD4+ T cell immunity within the FLUCOP consortium
Begue, Sarah; Waerlop, Gwenn; Salaun, Bruno; Janssens, Michel; Bellamy, Duncan; Cox, Rebecca Jane; Davies, Richard Allan; Gianchecchi, Elena; Medaglini, Donata; Montomoli, Emanuele; Pettini, Elena; Leroux-Roels, Geert; Clement, Frédéric; Pagnon, Anke (Journal article; Peer reviewed, 2022-10-20)Despite the knowledge that cell-mediated immunity (CMI) contributes to the reduction of severe influenza infection, transmission, and disease outcome, the correlates of protection for cell-mediated immunity remain still ... -
Herring roe oil in treatment of psoriasis – influence on immune cells and cytokine network
Petrovic, Aleksandra; Bueide, Ingvild Øye; Tveit, Kåre Steinar; Hallaråker, Hogne; Bjørndal, Bodil; Holmes, Timothy Dunstan; Davies, Richard Allan; Brokstad, Karl Albert; Bergum, Brith; Appel, Silke (Journal article; Peer reviewed, 2023)Background: Psoriasis is a chronic immune-mediated skin disease with systemic inflammation and comorbidities. Although the disease severity may vary over time, many patients suffer from mild to moderate disease. Often local ... -
Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome
Keindl, Magdalena; Davies, Richard Allan; Bergum, Brith; Brun, Johan Gorgas; Hammenfors, Daniel; Jonsson, Roland; Lyssenko, Valeriya; Appel, Silke (Journal article; Peer reviewed, 2022)Background Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune diseases. ... -
An optimized multiplex flow cytometry protocol for the analysis of intracellular signaling in peripheral blood mononuclear cells
Davies, Richard Allan; Vogelsang, Petra; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2016-09)Phosphoflow cytometry is increasingly being used as a tool for the discovery of biomarkers used in the treatment and monitoring of disease and therapy. The ability to measure numerous phospho-protein targets simultaneously ... -
Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary Sjögren's syndrome
Davies, Richard Allan; Sarkar, Irene; Hammenfors, Daniel; Bergum, Brith; Vogelsang, Petra; Solberg, Silje Michelsen; Gavasso, Sonia; Brun, Johan G; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2019-02-21)Primary Sjögren's syndrome (pSS) is associated with polymorphisms and mRNA expression profiles that are indicative of an exaggerated innate and type I IFN immune response. Excessive activation potential of signaling pathways ...