Browsing Bergen Open Research Archive by Author "Handel E, Adam"
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The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
Oftedal, Bergithe Eikeland; Maio, Stefano; Handel E, Adam; White PJ, Madeleine; Howie, Duncan; Davis, Simon; Prevot, Nicolas; Rota A, Ioanna; Deadman E, Mary; Kessler M, Benedict; Fischer, Roman; Trede S, Nikolaus; Sezgin, Erdinc; Maizels M, Rick; Holländer, Georg A. (Journal article; Peer reviewed, 2021)T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In the absence of the eukaryotic type II chaperonin complex, CCT, T ...