Browsing Bergen Open Research Archive by Author "Klein, Raphael"
Now showing items 1-3 of 3
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An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics
Espeland, Ludvik Olai; Georgiou, Charis; Klein, Raphael; Bhukya, Hemalatha; Haug, Bengt Erik; Underhaug, Jarl; Mainkar, Prathama S.; Brenk, Ruth (Journal article; Peer reviewed, 2021)FabF (3-oxoacyl-[acyl-carrier-protein] synthase 2), which catalyses the rate limiting condensation reaction in the fatty acid synthesis II pathway, is an attractive target for new antibiotics. Here, we focus on FabF from ... -
In silico identification and experimental validation of hits active against KPC-2 β-lactamase
Klein, Raphael; Linciano, Pasquale; Celenza, Guiseppe; Bellio, Pierangelo; Papaioannou, Sofia; Blazques, Jesus; Cendron, Laura; Brenk, Ruth; Tondi, Donatella (Peer reviewed; Journal article, 2018-11-29)Bacterial resistance has become a worldwide concern, particularly after the emergence of resistant strains overproducing carbapenemases. Among these, the KPC-2 carbapenemase represents a significant clinical challenge, ... -
Targeting the Class A Carbapenemase GES-5 via Virtual Screening
Klein, Raphael; Cendron, Laura; Montanari, Maria; Bellio, Pierangelo; Celenza, Giuseppe; Maso, Lorenzo; Tondi, Donatella; Brenk, Ruth (Journal article; Peer reviewed, 2020)The worldwide spread of β-lactamases able to hydrolyze last resort carbapenems contributes to the antibiotic resistance problem and menaces the successful antimicrobial treatment of clinically relevant pathogens. Class A ...