Blar i Bergen Open Research Archive på forfatter "Pedersen, Gabriel Kristian"
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Evaluation of the Sublingual Route for Administration of Influenza H5N1 Virosomes in Combination with the Bacterial Second Messenger c-di-GMP
Pedersen, Gabriel Kristian; Ebensen, Thomas; Gjeraker, Ingrid Hjetland; Svindland, Signe; Bredholt, Geir; Guzmán, Carlos Alberto; Cox, Rebecca Jane (Peer reviewed; Journal article, 2011-11-01)Avian influenza A H5N1 is a virus with pandemic potential. Mucosal vaccines are attractive as they have the potential to block viruses at the site of entry, thereby preventing both disease and further transmission. The ... -
Matrix M Adjuvanted H5N1 Vaccine Elicits Broadly Neutralizing Antibodies and Neuraminidase Inhibiting Antibodies in Humans That Correlate With In Vivo Protection
Zhou, Fan; Hansen, Lena; Pedersen, Gabriel Kristian; Grødeland, Gunnveig; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)The highly pathogenic avian influenza H5N1 viruses constantly evolve and give rise to novel variants that have caused widespread zoonotic outbreaks and sporadic human infections. Therefore, vaccines capable of eliciting ... -
Matrix M H5N1 vaccine induces cross-H5 clade humoral immune responses in a randomized clinical trial and provides protection from highly pathogenic influenza challenge in ferrets
Cox, Rebecca Jane; Major, Diane; Pedersen, Gabriel Kristian; Pathirana, Rishi; Höschler, Katja; Guilfoyle, Kate; Roseby, Sarah; Bredholt, Geir; Assmus, Jörg; Breakwell, Lucy; Campitelli, Laura; Sjursen, Haakon (Peer reviewed; Journal article, 2015-07-06)Background and Methods: Highly pathogenic avian influenza (HPAI) viruses constitute a pandemic threat and the development of effective vaccines is a global priority. Sixty adults were recruited into a randomized clinical ... -
A Novel Prophylaxis Strategy Using Liposomal Vaccine Adjuvant CAF09b Protects against Influenza Virus Disease
Zimmermann, Julie; Schmidt, Signe Tandrup; Trebbien, Ramona; Cox, Rebecca Jane; Zhou, Fan; Follmann, Frank; Pedersen, Gabriel Kristian; Christensen, Dennis (Journal article; Peer reviewed, 2022-02-06)The SARS-CoV-2 pandemic caused a massive health and societal crisis, although the fast development of effective vaccines reduced some of the impact. To prepare for future respiratory virus pandemics, a pan-viral prophylaxis ...