Blar i Bergen Open Research Archive på forfatter "Skadberg, Øyvind"
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Adding stress biomarkers to high-sensitivity cardiac troponin for rapid non-ST-elevation myocardial infarction rule-out protocols
Restan, Ingar Ziad; Sanchez, Ana Yufera; Steiro, Ole-Thomas; Lopez-Ayala, Pedro; Tjora, Hilde Lunde; Langørgen, Jørund; Omland, Torbjørn; Boeddinghaus, Jasper; Nestelberger, Thomas; Koechlin, Luca; Collinson, Paul; Bjørneklett, Rune Oskar; Vikenes, Kjell; Strand, Heidi; Skadberg, Øyvind; Mjelva, Øistein; Larsen, Alf Inge; Vernon, Bonarjee; Mueller, Christian; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2022)Aims This study tested the hypothesis that combining stress-induced biomarkers (copeptin or glucose) with high-sensitivity cardiac troponin (hs-cTn) increases diagnostic accuracy for non-ST-elevation myocardial infarction ... -
Cardiac Troponin Assays With Improved Analytical Quality: A Trade-Off Between Enhanced Diagnostic Performance and Reduced Long-Term Prognostic Value
Tjora, Hilde Lunde; Steiro, Ole-Thomas; Langørgen, Jørund; Bjørneklett, Rune; Nygård, Ottar; Skadberg, Øyvind; Bonarjee, Vernon; Collinson, Paul; Omland, Torbjørn; Vikenes, Kjell; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2020)Background Cardiac troponin (cTn) permits early rule‐out/rule‐in of patients admitted with possible non–ST‐segment–elevation myocardial infarction. In this study, we developed an admission and a 0/1 hour rule‐out/rule‐in ... -
Determinants of interindividual variation in exercise-induced cardiac troponin I levels
Bjørkavoll-Bergseth, Magnus; Erevik, Christine Bjørkvik; Kleiven, Øyunn; Eijsvogels, Thijs M. H.; Skadberg, Øyvind; Frøysa, Vidar; Wiktorski, Tomasz; Auestad, Bjørn; Edvardsen, Thor; Aakre, Kristin Moberg; Ørn, Stein (Journal article; Peer reviewed, 2021)Background: Postexercise cardiac troponin levels show considerable interindividual variations. This study aimed to identify the major determinants of this postexercise variation in cardiac troponin I (cTnI) following 3 ... -
Diagnostic Performance of Novel Troponin Algorithms for the Rule-Out of Non-ST-Elevation Acute Coronary Syndrome
Tjora, Hilde Lunde; Steiro, Ole-Thomas; Langørgen, Jørund; Bjørneklett, Rune Oskar; Skadberg, Øyvind; Bonarjee, Vernon V S; Mjelva, Øistein; Collinson, Paul; Omland, Torbjørn; Vikenes, Kjell; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2022)Background The European Society of Cardiology (ESC) rule-out algorithms use cutoffs optimized for exclusion of non-ST elevation myocardial infarction (NSTEMI). We investigated these and several novel algorithms for the ... -
Duration of elevated heart rate Is an important predictor of exercise-induced troponin elevation
Bjørkavoll-Bergseth, Magnus; Kleiven, Øyunn; Auestad, Bjørn Henrik; Eftestøl, Trygve Christian; Oskal, Kay Raymond; Nygård, Martin; Skadberg, Øyvind; Aakre, Kristin Moberg; Melberg, Tor Harald; Gjesdal, Knut; Ørn, Stein (Journal article; Peer reviewed, 2020)Background The precise mechanisms causing cardiac troponin (cTn) increase after exercise remain to be determined. The aim of this study was to investigate the impact of heart rate (HR) on exercise‐induced cTn increase by ... -
Endurance exercise training volume is not associated with progression of coronary artery calcification
Kleiven, Øyunn; Bjørkavoll-Bergseth, Magnus; Omland, Torbjørn; Aakre, Kristin Moberg; Frøysa, Vidar; Erevik, Christine B.; Greve, Ole Jacob; Melberg, Tor Harald; Auestad, Bjørn Henrik; Skadberg, Øyvind; Edvardsen, Thor; Ørn, Stein (Journal article; Peer reviewed, 2020)Background Recent cross‐sectional studies have suggested a dose‐dependent relationship between lifelong exposure to physical activity and the burden of calcified coronary artery disease (CAD). No longitudinal studies have ... -
Glycated albumin and continuous glucose monitoring metrics across pregnancy in women with pre-gestational diabetes
Toft, Johanne Holm; Dalen, Ingvild; Skadberg, Øyvind; Gøransson, Lasse Gunnar; Økland, Inger; Bleskestad, Inger Hjørdis (Journal article; Peer reviewed, 2022)Introduction: Glycated albumin (GA), a biomarker reflecting short-term glycaemia, may be useful to assess glycaemic control in pregnancy. We examined the association between GA and continuous glucose monitoring (CGM) metrics ... -
Glycated albumin in pregnancy: LC-MS/MS-based reference interval in healthy, nulliparous Scandinavian women and its diagnostic accuracy in gestational diabetes mellitus
Toft, Johanne Holm; Bleskestad, Inger Hjørdis; Skadberg, Øyvind; Gøransson, Lasse Gunnar; Økland, Inger (Journal article; Peer reviewed, 2022)Glycated albumin (GA) may be a useful biomarker of glycemia in pregnancy. The aim of this study was to establish the reference interval (RI) for GA, analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), ... -
Hepcidin analysis in pneumonia: Comparison of immunoassay and LC-MS/MS
Oppen, Kjersti; Brede, Cato; Skadberg, Øyvind; Steinsvik, Trude; Holter, Jan Cato; Michelsen, Annika Elisabet; Heggelund, Lars (Journal article; Peer reviewed, 2023)Background: The iron-regulatory hormone hepcidin is a promising biomarker to differentiate anaemia of inflammation from iron deficiency. Plasma hepcidin concentrations increase substantially during inflammation, and the ... -
Hepcidin and Ferritin Predict Microbial Etiology in Community-Acquired Pneumonia
Oppen, Kjersti; Ueland, Thor; Siljan, William Ward; Skadberg, Øyvind; Brede, Cato; Lauritzen, Trine; Aukrust, Pål; Steinsvik, Trude; Husebye, Einar; Michelsen, Annika; Holter, Jan Cato; Heggelund, Lars (Journal article; Peer reviewed, 2021)Background Iron is crucial for survival and growth of microbes. Consequently, limiting iron availability is a human antimicrobial defense mechanism. We explored iron and iron-related proteins as potential biomarkers in ... -
Hepcidin predicts 5-year mortality after community-acquired pneumonia
Oppen, Kjersti; Ueland, Thor; Michelsen, Annika Elisabet; Aukrust, Pål; Steinsvik, Trude; Skadberg, Øyvind; Brede, Cato; Siljan, William Ward; Husebye, Einar; Holter, Jan Cato; Heggelund, Lars (Journal article; Peer reviewed, 2022)Background Virtually all living organisms, including microbes and humans, depend on iron to survive and grow. During an infection, the plasma level of iron and several iron-related proteins change substantially. We ... -
High-Sensitivity Cardiac Troponin I and T Response Following Strenuous Activity is Attenuated by Smokeless Tobacco: NEEDED (North Sea Race Endurance Exercise Study) 2014
Skranes, Julia Brox; Kleiven, Øyunn; Aakre, Kristin Moberg; Skadberg, Øyvind; Melberg, Tor Harald; Omland, Torbjørn; Ørn, Stein (Journal article; Peer reviewed, 2020)Background Use of snus, a smokeless tobacco product, is increasing in Scandinavia. Strenuous physical activity is associated with an acute increase in high‐sensitivity cardiac troponin (swhs‐cTn) concentrations. Current ... -
Kinetics of 2 different high-sensitive troponins during targeted temperature management in out-of-hospital cardiac arrest patients with acute myocardial infarction: a post hoc sub-study of a randomised clinical trial
Larsen, Alf Inge; Grejs, Anders Morten; Vistisen, Simon Tilma; Strand, Kristian; Skadberg, Øyvind; Jeppesen, Anni Nørgaard; Duez, Christophe H. V.; Kirkegaard, Hans; Søreide, Eldar (Journal article; Peer reviewed, 2022)Introduction Short term hypothermia has been suggested to have cardio protective properties in acute myocardial infarction (AMI) by reducing infarct size as assessed by troponins. There are limited data on the kinetics ... -
Klotho and Fibroblast Growth Factor 23 Are Independent of Vitamin D, and Unlike Vitamin D, Are Not Associated With Graft- and Patient Survival After Kidney Transplantation
Thorsen, Inga Strand; Bleskestad, Inger Hjørdis; Åsberg, Anders; Jonsson, Grete; Skadberg, Øyvind; Heldal, Kristian; Gøransson, Lasse Gunnar (Journal article; Peer reviewed, 2023)Background: Short-term survival after kidney transplantation is excellent but long-term survival remains suboptimal. The aim of the study was to explore the relationship between soluble α-Klotho (sKlotho) and intact ... -
Neutrophil gelatinase-associated lipocalin, fibroblast growth factor 23, and soluble klotho in long-term kidney donors
Thorsen, Inga Strand; Bleskestad, Inger Hjørdis; Jonsson, Grete; Skadberg, Øyvind; Gøransson, Lasse (Journal article; Peer reviewed, 2016)Background: The best treatment for end-stage renal disease (ESRD) is kidney transplantation. Twenty-seven percent of transplantations in Norway are from living donors. Recent studies have shown an increased risk of ESRD ... -
Occult obstructive coronary artery disease is associated with prolonged cardiac troponin elevation following strenuous exercise
Kleiven, Øyunn; Omland, Torbjørn; Skadberg, Øyvind; Melberg, Tor Harald; Bjørkavoll-Bergseth, Magnus; Auestad, Bjørn Henrik; Bergseth, Rolf; Greve, Ole Jacob; Aakre, Kristin Moberg; Ørn, Stein (Peer reviewed; Journal article, 2019)Background: Sudden cardiac death among middle-aged recreational athletes is predominantly due to myocardial ischaemia. This study examined whether measuring cardiac troponin I and T (cTnI and cTnT) after strenuous exercise ... -
Predictors of long-term symptom burden and quality of life in patients hospitalised with chest pain: a prospective observational study
Saeed, Nasir; Norekvål, Tone Merete; Steiro, Ole-Thomas; Tjora, Hilde Lunde; Langørgen, Jørund; Bjørneklett, Rune Oskar; Skadberg, Øyvind; Bonarjee, Vernon V S; Mjelva, Øistein; Omland, Torbjørn; Vikenes, Kjell; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2022)Objective: To describe the magnitude and predictors of symptom burden (SB) and quality of life (QoL) 3 months after hospital admission for acute chest pain. Design: Prospective observational study. Setting: Single ... -
Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation
Kleiven, Øyunn; Omland, Torbjørn; Skadberg, Øyvind; Melberg, Tor Harald; Bjørkavoll-Bergseth, Magnus; Auestad, Bjørn Henrik; Bergseth, Rolf; Greve, Ole Jacob; Aakre, Kristin Moberg; Ørn, Stein (Peer reviewed; Journal article, 2019)Background: The underlying mechanisms of the exercise-induced increase in cardiac troponins (cTn) are poorly understood. The aim of this study was to identify independent determinants of exercise-induced cTn increase in a ... -
Regular consumption of cod liver oil is associated with reduced basal and exercise-induced C-reactive protein levels; a prospective observational trial: A NEEDED (The North Sea Race Endurance Exercise Study) 2014 sub-study
Hansen, Mette Wærstad; Ørn, Stein; Erevik, Christine B.; Bjørkavoll-Bergseth, Magnus Friestad; Skadberg, Øyvind; Melberg, Tor Harald; Aakre, Kristin Moberg; Kleiven, Øyunn (Journal article; Peer reviewed, 2021)Background Dietary supplement use among recreational athletes is common, with the intention of reducing inflammation and improving recovery. We aimed to describe the relationship between omega-3 fatty acid supplement use ... -
The relationship between Fibroblast Growth Factor 23 (FGF23) and cardiac MRI findings following primary PCI in patients with acute first time STEMI
Thorsen, Inga Strand; Gøransson, Lasse Gunnar; Ueland, Thor; Aukrust, Pål; Manhenke, Cord A; Skadberg, Øyvind; Jonsson, Grete; Ørn, Stein (Journal article; Peer reviewed, 2021)Background: Fibroblast growth factor 23 (FGF23) is a regulator of mineral metabolism, that has been linked to myocardial remodeling including development of left ventricular (LV) hypertrophy and myocardial fibrosis. The ...