dc.contributor.author | Oftedal, Bergithe Eikeland | |
dc.contributor.author | Maio, Stefano | |
dc.contributor.author | Handel E, Adam | |
dc.contributor.author | White PJ, Madeleine | |
dc.contributor.author | Howie, Duncan | |
dc.contributor.author | Davis, Simon | |
dc.contributor.author | Prevot, Nicolas | |
dc.contributor.author | Rota A, Ioanna | |
dc.contributor.author | Deadman E, Mary | |
dc.contributor.author | Kessler M, Benedict | |
dc.contributor.author | Fischer, Roman | |
dc.contributor.author | Trede S, Nikolaus | |
dc.contributor.author | Sezgin, Erdinc | |
dc.contributor.author | Maizels M, Rick | |
dc.contributor.author | Holländer, Georg A. | |
dc.date.accessioned | 2022-04-26T07:16:57Z | |
dc.date.available | 2022-04-26T07:16:57Z | |
dc.date.created | 2022-01-25T10:26:49Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2399-3642 | |
dc.identifier.uri | https://hdl.handle.net/11250/2992664 | |
dc.description.abstract | T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In the absence of the eukaryotic type II chaperonin complex, CCT, T cell activation induced changes in the proteome are compromised including the formation of nuclear actin filaments and the formation of a normal cell stress response. Consequently, thymocyte maturation and selection, and T cell homeostatic maintenance and receptor-mediated activation are severely impaired. In the absence of CCT-controlled protein folding, Th2 polarization diverges from normal differentiation with paradoxical continued IFN-γ expression. As a result, CCT-deficient T cells fail to generate an efficient immune protection against helminths as they are unable to sustain a coordinated recruitment of the innate and adaptive immune systems. These findings thus demonstrate that normal T cell biology is critically dependent on CCT-controlled proteostasis and that its absence is incompatible with protective immunity. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright Crown 2021 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1038/s42003-021-02203-0 | |
dc.identifier.cristin | 1989214 | |
dc.source.journal | Communications Biology | en_US |
dc.source.pagenumber | 681 | en_US |
dc.relation.project | Norges forskningsråd: 250030 | en_US |
dc.identifier.citation | Communications Biology. 2021, 4, 681. | en_US |
dc.source.volume | 4 | en_US |