dc.contributor.author | Smith, Carl Inge Edvard | |
dc.contributor.author | Zain, Rula | |
dc.contributor.author | Österborg, Anders | |
dc.contributor.author | Palma, Marzia | |
dc.contributor.author | Buggert, Marcus | |
dc.contributor.author | Bergman, Peter | |
dc.contributor.author | Bryceson, Yenan | |
dc.date.accessioned | 2022-07-05T09:39:27Z | |
dc.date.available | 2022-07-05T09:39:27Z | |
dc.date.created | 2022-04-03T14:31:16Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0300-9475 | |
dc.identifier.uri | https://hdl.handle.net/11250/3002719 | |
dc.description.abstract | Infections with SARS-CoV-2 have been unduly severe in patients with haematological malignancies, in particular in those with chronic lymphocytic leukaemia (CLL). Based on a series of observations, we propose that an underlying mechanism for the aggressive clinical course of COVID-19 in CLL is a paucity of plasmacytoid dendritic cells (pDCs) in these patients. Indeed, pDCs express Toll-like receptor 7 (TLR7), which together with interferon-regulatory factor 7 (IRF7), enables pDCs to produce large amounts of type I interferons, essential for combating COVID-19. Treatment of CLL with Bruton's tyrosine kinase (BTK) inhibitors increased the number of pDCs, likely secondarily to the reduction in the tumour burden. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Do reduced numbers of plasmacytoid dendritic cells contribute to the aggressive clinical course of COVID-19 in chronic lymphocytic leukaemia? | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 the authors | en_US |
dc.source.articlenumber | e13153 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1111/sji.13153 | |
dc.identifier.cristin | 2014879 | |
dc.source.journal | Scandinavian Journal of Immunology | en_US |
dc.identifier.citation | Scandinavian Journal of Immunology. 2022, 95 (4), e13153. | en_US |
dc.source.volume | 95 | en_US |
dc.source.issue | 4 | en_US |