dc.contributor.author | Haave, Hilde | |
dc.contributor.author | Ljøkjel, Borghild | |
dc.contributor.author | Lybak, Helene | |
dc.contributor.author | Moe, Svein Erik Emblem | |
dc.contributor.author | Berge, Jan Erik | |
dc.contributor.author | Vintermyr, Olav Karsten | |
dc.contributor.author | Helgeland, Lars | |
dc.contributor.author | Aarstad, Hans Jørgen | |
dc.date.accessioned | 2022-12-12T10:27:06Z | |
dc.date.available | 2022-12-12T10:27:06Z | |
dc.date.created | 2022-11-07T08:52:18Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2227-9059 | |
dc.identifier.uri | https://hdl.handle.net/11250/3037213 | |
dc.description.abstract | Oropharynx squamous cell carcinoma (OPSCC) is of special interest because human papilloma virus (HPV) and/or smoking cause this disease. Influxes of inflammatory cells into such tumors are known to vary with prognoses. Aims: To study whether the density of tumor-infiltrating T lymphocytes and tumor-infiltrating macrophages predicted general 20-year overall survival (OS), as well as OS with only disease-specific survival (DSS) patients included. Methods: Biopsies from patients treated for OPSCC (n = 180) were stained by immunohistochemistry and the tumor cell macrophage (CD68), pan T lymphocytes (CD3), and regulatory T lymphocytes (Foxp3) densities were determined. The HE-determined percentage of matured tumor cells and the rate of invasion were calculated, and stromal desmoplasia were performed. Tumor HPV presence was studied by PCR. Twenty-year OS and five-year DSS patients were determined. Results: Tumor HPV status strongly predicted survival. High tumor infiltration of CD3, Foxp3 and CD68-positive cells predicted better twenty-year OS, with and without HPV stratification. Foxp3 and CD68 levels predicted OS, and 20-year among DSS patients, primarily among HPV(+) patients. Tumor HE-derived variables did not predict such survival. Conclusions: Tumor HPV status, level of Foxp3 tumor-infiltrating lymphocytes and CD68 tumor-infiltrating macrophages predicted up to 20-year OS of both all patients and disease-specific survived patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Tumor HPV status, level of regulatory T cells and macrophage infiltration predict up to 20-year non-disease-specific survival in oropharynx squamous cell carcinoma patients | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
dc.source.articlenumber | 2484 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.3390/biomedicines10102484 | |
dc.identifier.cristin | 2069700 | |
dc.source.journal | Biomedicines | en_US |
dc.identifier.citation | Biomedicines. 2022, 10 (10), 2484. | en_US |
dc.source.volume | 10 | en_US |
dc.source.issue | 10 | en_US |