dc.contributor.author | Hooli, Shubhada | |
dc.contributor.author | King, Carina | |
dc.contributor.author | McCollum, Eric D. | |
dc.contributor.author | Colbourn, Tim | |
dc.contributor.author | Lufesi, Norman | |
dc.contributor.author | Mwansambo, Charles | |
dc.contributor.author | Gregory, Christopher J. | |
dc.contributor.author | Thamthitiwat, Somsak | |
dc.contributor.author | Cutland, Clare | |
dc.contributor.author | Madhi, Shabir Ahmed | |
dc.contributor.author | Nunes, Marta C. | |
dc.contributor.author | Gessner, Bradford D. | |
dc.contributor.author | Hazir, Tabish | |
dc.contributor.author | Mathew, Joseph L. | |
dc.contributor.author | Addo-Yobo, Emmanuel | |
dc.contributor.author | Chisaka, Noel | |
dc.contributor.author | Hassan, Mumtaz | |
dc.contributor.author | Hibberd, Patricia L. | |
dc.contributor.author | Jeena, Prakash | |
dc.contributor.author | Lozano, Juan M. | |
dc.contributor.author | MacLeod, William B. | |
dc.contributor.author | Patel, Archana | |
dc.contributor.author | Thea, Donald M. | |
dc.contributor.author | Nguyen, Ngoc Tuong Vy | |
dc.contributor.author | Zaman, Syed MA. | |
dc.contributor.author | Ruvinsky, Raul O. | |
dc.contributor.author | Lucero, Marilla | |
dc.contributor.author | Kartasasmita, Cissy B. | |
dc.contributor.author | Turner, Claudia | |
dc.contributor.author | Asghar, Rai | |
dc.contributor.author | Banajeh, Salem | |
dc.contributor.author | Iqbal, Imran | |
dc.contributor.author | Maulen-Radovan, Irene | |
dc.contributor.author | Mino-Leon, Greta | |
dc.contributor.author | Saha, Samir K. | |
dc.contributor.author | Santosham, Mathuram | |
dc.contributor.author | Singhi, Sunit | |
dc.contributor.author | Awasthi, Shally | |
dc.contributor.author | Bavdekar, Ashish | |
dc.contributor.author | Chou, Monidarin | |
dc.contributor.author | Nymadawa, Pagbajabyn | |
dc.contributor.author | Pape, Jean-William | |
dc.contributor.author | Paranhos-Baccala, Glaucia | |
dc.contributor.author | Picot, Valentina Sanchez | |
dc.contributor.author | Rakoto-Andrianarivelo, Mala | |
dc.contributor.author | Rouzier, Vanessa | |
dc.contributor.author | Russomando, Graciela | |
dc.contributor.author | Sylla, Mariam | |
dc.contributor.author | Vanhems, Philippe | |
dc.contributor.author | Wang, Jianwei | |
dc.contributor.author | Basnet, Sudha | |
dc.contributor.author | Strand, Tor Arne | |
dc.contributor.author | Neuman, Mark I. | |
dc.contributor.author | Arroyo, Luis Martinez | |
dc.contributor.author | Echavarria, Marcela | |
dc.contributor.author | Bhatnagar, Shinjini | |
dc.contributor.author | Wadhwa, Nitya | |
dc.contributor.author | Lodha, Rakesh | |
dc.contributor.author | Aneja, Satinder | |
dc.contributor.author | Gentile, Angela | |
dc.contributor.author | Chadha, Mandeep | |
dc.contributor.author | Hirve, Siddhivinayak | |
dc.contributor.author | O'Grady, Kerry-Ann F. | |
dc.contributor.author | Clara, Alexey W. | |
dc.contributor.author | Rees, Chris A. | |
dc.contributor.author | Campbell, Harry | |
dc.contributor.author | Nair, Harish | |
dc.contributor.author | Falconer, Jennifer | |
dc.contributor.author | Williams, Linda J. | |
dc.contributor.author | Horne, Margaret | |
dc.contributor.author | Qazi, Shamim A. | |
dc.contributor.author | Nisar, Yasir Bin | |
dc.date.accessioned | 2023-06-30T12:48:17Z | |
dc.date.available | 2023-06-30T12:48:17Z | |
dc.date.created | 2023-06-28T08:49:38Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1201-9712 | |
dc.identifier.uri | https://hdl.handle.net/11250/3074728 | |
dc.description.abstract | Objectives: We determined the pulse oximetry benefit in pediatric pneumonia mortality risk stratification and chest-indrawing pneumonia in-hospital mortality risk factors.
Methods: We report the characteristics and in-hospital pneumonia-related mortality of children aged 2-59 months who were included in the Pneumonia Research Partnership to Assess WHO Recommendations dataset. We developed multivariable logistic regression models of chest-indrawing pneumonia to identify mortality risk factors.
Results: Among 285,839 children, 164,244 (57.5%) from hospital-based studies were included. Pneumonia case fatality risk (CFR) without pulse oximetry measurement was higher than with measurement (5.8%, 95% confidence interval [CI] 5.6-5.9% vs 2.1%, 95% CI 1.9-2.4%). One in five children with chest-indrawing pneumonia was hypoxemic (19.7%, 95% CI 19.0-20.4%), and the hypoxemic CFR was 10.3% (95% CI 9.1-11.5%). Other mortality risk factors were younger age (either 2-5 months [adjusted odds ratio (aOR) 9.94, 95% CI 6.67-14.84] or 6-11 months [aOR 2.67, 95% CI 1.71-4.16]), moderate malnutrition (aOR 2.41, 95% CI 1.87-3.09), and female sex (aOR 1.82, 95% CI 1.43-2.32).
Conclusion: Children with a pulse oximetry measurement had a lower CFR. Many children hospitalized with chest-indrawing pneumonia were hypoxemic and one in 10 died. Young age and moderate malnutrition were risk factors for in-hospital chest-indrawing pneumonia-related mortality. Pulse oximetry should be integrated in pneumonia hospital care for children under 5 years. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 the authors | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1016/j.ijid.2023.02.005 | |
dc.identifier.cristin | 2158888 | |
dc.source.journal | International Journal of Infectious Diseases | en_US |
dc.source.pagenumber | 240-250 | en_US |
dc.identifier.citation | International Journal of Infectious Diseases. 2023, 129, 240-250. | en_US |
dc.source.volume | 129 | en_US |