dc.contributor.author | Kessler, Ute | en_US |
dc.contributor.author | Schøyen, Helle Kristine | en_US |
dc.contributor.author | Andreassen, Ole Andreas | en_US |
dc.contributor.author | Eide, Geir Egil | en_US |
dc.contributor.author | Hammar, Åsa | en_US |
dc.contributor.author | Malt, Ulrik Fredrik | en_US |
dc.contributor.author | Ødegaard, Ketil Joachim | en_US |
dc.contributor.author | Morken, Gunnar | en_US |
dc.contributor.author | Sundet, Kjetil Søren | en_US |
dc.contributor.author | Vaaler, Arne Einar | en_US |
dc.date.accessioned | 2015-12-16T13:43:16Z | |
dc.date.available | 2015-12-16T13:43:16Z | |
dc.date.issued | 2013-04-04 | |
dc.Published | BMC Psychiatry 2013, 13 | eng |
dc.identifier.issn | 1471-244X | |
dc.identifier.uri | https://hdl.handle.net/1956/10760 | |
dc.description.abstract | Background The literature on the neuropsychological profiles in Bipolar disorder (BD) depression is sparse. The aims of the study were to assess the neurocognitive profiles in treatment-resistant, acutely admitted BD depression inpatients, to compare the neurocognitive functioning in patients with BD I and II, and to identify the demographic and clinical illness characteristics associated with cognitive functioning. Methods Acutely admitted BD I (n = 19) and BD II (n = 32) inpatients who fulfilled the DSM-IV-TR criteria for a major depressive episode were tested with the MATRICS Consensus Cognitive Battery (MCCB), the Wechsler Abbreviated Scale of Intelligence, the National Adult Reading Test, and a battery of clinical measures. Results Neurocognitive impairments were evident in the BD I and BD II depression inpatients within all MCCB domains. The numerical scores on all MCCB-measures were lower in the BD I group than in the BD II group, with a significant difference on one of the measures, category fluency. 68.4% of the BD I patients had clinically significant impairment (>1.5 SD below normal mean) in two or more domains compared to 37.5% of the BD II patients (p = 0.045). A significant reduction in IQ from the premorbid to the current level was seen in BD I but not BD II patients. Higher age was associated with greater neurocognitive deficits compared to age-adjusted published norms. Conclusions A high proportion of patients with therapy-resistant BD I or II depression exhibited global neurocognitive impairments with clinically significant severity. The cognitive impairments were more common in BD I compared to BD II patients, particularly processing speed. These findings suggest that clinicians should be aware of the severe neurocognitive dysfunction in treatment-resistant bipolar depression, particularly in BD I. | en_US |
dc.language.iso | eng | eng |
dc.publisher | BioMed Central | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | eng |
dc.subject | Bipolar disorder depression | eng |
dc.subject | Bipolar II disorder | eng |
dc.title | Neurocognitive profiles in treatment-resistant bipolar I and bipolar II disorder depression | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-09-11T13:15:59Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright Kessler et al.; licensee BioMed Central Ltd. | |
dc.identifier.doi | https://doi.org/10.1186/1471-244x-13-105 | |
dc.identifier.cristin | 1023736 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757 | |
dc.subject.nsi | VDP::Midical sciences: 700::Clinical medical sciences: 750::Psychiatry, child psychiatry: 757 | |
dc.subject.nsi | VDP::Medisinske Fag: 700 | en_US |