dc.contributor.author | Pelissier, Fanny | en_US |
dc.contributor.author | Schapiro, Denis | en_US |
dc.contributor.author | Chang, Hang | en_US |
dc.contributor.author | Borowsky, Alexander D. | en_US |
dc.contributor.author | Lee, Jonathan K. | en_US |
dc.contributor.author | Parvin, Bahram | en_US |
dc.contributor.author | Stampfer, Martha R. | en_US |
dc.contributor.author | LaBarge, Mark A. | en_US |
dc.contributor.author | Bodenmiller, Bernd | en_US |
dc.contributor.author | Lorens, James B. | en_US |
dc.date.accessioned | 2018-05-28T11:35:00Z | |
dc.date.available | 2018-05-28T11:35:00Z | |
dc.date.issued | 2018-04 | |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | https://hdl.handle.net/1956/17728 | |
dc.description.abstract | Aging is associated with tissue-level changes in cellular composition that are correlated with increased susceptibility to disease. Aging human mammary tissue shows skewed progenitor cell potency, resulting in diminished tumor-suppressive cell types and the accumulation of defective epithelial progenitors. Quantitative characterization of these age-emergent human cell subpopulations is lacking, impeding our understanding of the relationship between age and cancer susceptibility. We conducted single-cell resolution proteomic phenotyping of healthy breast epithelia from 57 women, aged 16–91 years, using mass cytometry. Remarkable heterogeneity was quantified within the two mammary epithelial lineages. Population partitioning identified a subset of aberrant basal-like luminal cells that accumulate with age and originate from age-altered progenitors. Quantification of age-emergent phenotypes enabled robust classification of breast tissues by age in healthy women. This high-resolution mapping highlighted specific epithelial subpopulations that change with age in a manner consistent with increased susceptibility to breast cancer. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Cell Press | eng |
dc.relation.ispartof | <a href="http://hdl.handle.net/1956/17729" target="_blank">The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor</a> | |
dc.rights | Attribution CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | eng |
dc.title | High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2018 The Author(s) | |
dc.identifier.doi | https://doi.org/10.1016/j.celrep.2018.03.114 | |
dc.source.journal | Cell reports | |
dc.source.40 | 23 | |
dc.source.pagenumber | 1205-1219 | |