dc.contributor.author | Ager-Wick, Gunnhild Victoria Trym | |
dc.date.accessioned | 2019-06-27T00:32:01Z | |
dc.date.available | 2019-06-27T00:32:01Z | |
dc.date.issued | 2019-06-27 | |
dc.date.submitted | 2019-06-26T22:00:04Z | |
dc.identifier.uri | https://hdl.handle.net/1956/20464 | |
dc.description.abstract | Magnetic resonance spectroscopy with the use of spectral editing, provides direct measurements of metabolites with low-concentrations, like GABA+ and GSH, in vivo in the human brain. The most common sequences used in spectral editing are HERMES and MEGA-PRESS, which are typically implemented as work-in-progress sequences at research sites and thus not standardized across vendors. Postdoctoral Fellow Muhammad Saleh and colleagues at the Johns Hopkins University School of Medicine, Baltimore, USA, therefore recently developed a universal editing sequence with common RF pulse shapes and timings for major MR vendors. As part of the collaboration with the group in Baltimore, GE and Siemens 3 Tesla systems at the Department of Radiology, Haukeland University Hospital, are used to test the universal HERMES and MEGA-PRESS sequences and compare to vendor provided (vendor-native) work-in-progress versions of HERMES and MEGA-PRESS respectively. This thesis aims to test the reproducibility of GABA+ and GSH using these editing techniques, to see if the values from HERMES and MEGA-PRESS correlate on either system, and investigate if the universal implementation is superior to the vendor specific implementations for measurements across vendors. As such, this thesis provides a summary of the current use of the vendor-native and universal-sequences and for the first time compares, vendor specific implementations with universal sequences in the field of GABA+ and GSH edited MRS. Areas were further optimization and standardization is needed are discussed. This project is part of the ongoing research in the Bergen fMRI group, University of Bergen/ Haukeland University Hospital. | en_US |
dc.description.abstract | Magnetic resonance spectroscopy with the use of spectral editing, provides direct measurements of metabolites with low-concentrations, like GABA+ and GSH, in vivo in the human brain. The most common sequences used in spectral editing are HERMES and MEGA-PRESS, which are typically implemented as work-in-progress sequences at research sites and thus not standardized across vendors. Postdoctoral Fellow Muhammad Saleh and colleagues at the Johns Hopkins University School of Medicine, Baltimore, USA, therefore recently developed a universal editing sequence with common RF pulse shapes and timings for major MR vendors. As part of the collaboration with the group in Baltimore, GE and Siemens 3 Tesla systems at the Department of Radiology, Haukeland University Hospital, are used to test the universal HERMES and MEGA-PRESS sequences and compare to vendor provided (vendor-native) work-in-progress versions of HERMES and MEGA-PRESS respectively. This thesis aims to test the reproducibility of GABA+ and GSH using these editing techniques, to see if the values from HERMES and MEGA-PRESS correlate on either system, and investigate if the universal implementation is superior to the vendor specific implementations for measurements across vendors. As such, this thesis provides a summary of the current use of the vendor-native and universal-sequences and for the first time compares, vendor specific implementations with universal sequences in the field of GABA+ and GSH edited MRS. Areas were further optimization and standardization is needed are discussed. This project is part of the ongoing research in the Bergen fMRI group, University of Bergen/ Haukeland University Hospital. | en_US |
dc.language.iso | nob | |
dc.publisher | The University of Bergen | en_US |
dc.subject | Medical physics | |
dc.title | Measurements of GABA and GSH with Magnetic Resonance Spectroscopy using HERMES and MEGA-PRESS | |
dc.title.alternative | Measurements of GABA and GSH with Magnetic Resonance Spectroscopy using HERMES and MEGA-PRESS | |
dc.type | Master thesis | |
dc.date.updated | 2019-06-26T22:00:04Z | |
dc.rights.holder | Copyright the Author. All rights reserved | en_US |
dc.description.degree | Masteroppgave i fysikk | en_US |
dc.description.localcode | PHYS399 | |
dc.description.localcode | MAMN-PHYS | |
dc.subject.nus | 752199 | |
fs.subjectcode | PHYS399 | |
fs.unitcode | 12-24-0 | |