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dc.contributor.authorTekpli, Xavieren_US
dc.contributor.authorLien, Tonje Gulbrandsenen_US
dc.contributor.authorRøssevold, Andreas Hagenen_US
dc.contributor.authorNebdal, Daniel J.H.en_US
dc.contributor.authorBorgen, Elinen_US
dc.contributor.authorOhnstad, Hege Omaen_US
dc.contributor.authorKyte, Jon Aen_US
dc.contributor.authorVallon-Christersson, Johanen_US
dc.contributor.authorFongaard, Marieen_US
dc.contributor.authorDue, Eldri Undlienen_US
dc.contributor.authorSvartdal, Lisa Gregussonen_US
dc.contributor.authorSveli, My Anh Tuen_US
dc.contributor.authorGarred, Øysteinen_US
dc.contributor.authorFrigessi Di Rattalma, Arnoldoen_US
dc.contributor.authorSahlberg, Kristine Kleivien_US
dc.contributor.authorSørlie, Thereseen_US
dc.contributor.authorRussnes, Hege Elisabeth Gierckskyen_US
dc.contributor.authorNaume, Bjørnen_US
dc.contributor.authorKristensen, Vessela N.en_US
dc.date.accessioned2020-08-14T12:24:29Z
dc.date.available2020-08-14T12:24:29Z
dc.date.issued2019
dc.PublishedTekpli X, Lien TGL, Røssevold AH, Nebdal D, Borgen E, Ohnstad HO, Kyte JA, Vallon-Christersson J, Fongaard M, Due EU, Svartdal LG, Sveli MA, Garred Ø, Frigessi Di Rattalma A, Sahlberg K, Sørlie T, Russnes HE, Naume B, Kristensen VN. An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment. Nature Communications. 2019;10:5499eng
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/1956/23781
dc.description.abstractHow mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated with a worse prognosis independently of known clinicopathological features. Furthermore, immune clusters are associated with response to neoadjuvant chemotherapy. In silico dissection of the immune contexture of the clusters identified Cluster A as immune cold, Cluster C as immune hot while Cluster B has a pro-tumorigenic immune infiltration. Through phenotypical analysis, we find epithelial mesenchymal transition and proliferation associated with the immune clusters and mutually exclusive in breast cancers. Here, we describe immune clusters which improve the prognostic accuracy of immune contexture in breast cancer. Our discovery of a novel independent prognostic factor in breast cancer highlights a correlation between tumor phenotype and immune contexture.en_US
dc.language.isoengeng
dc.publisherNature Researcheng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.titleAn independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironmenten_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2020-01-30T06:38:19Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2019 The Authors
dc.identifier.doihttps://doi.org/10.1038/s41467-019-13329-5
dc.identifier.cristin1778279
dc.source.journalNature Communications


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