Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles
Prandina, Anthony; Herfindal, Lars; Radix, S; Rongved, Pål; Doskeland, Stein Ove; Le Borgne, Marc; Perret, F
Journal article, Peer reviewed
Published version
Åpne
Permanent lenke
https://hdl.handle.net/1956/24436Utgivelsesdato
2018Metadata
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Originalversjon
https://doi.org/10.1080/14756366.2017.1421638Sammendrag
Phenazine is known to regroup planar nitrogen-containing heterocyclic compounds. It was used here to
enhance the bioavailability of the biologically important compound iodinin, which is near insoluble in
aqueous solutions. Its water solubility has led to the development of new formulations using diverse
amphiphilic a-cyclodextrins (CDs). With the per-[6-desoxy-6-(3-perfluorohexylpropanethio)-2,3-di-O-methyl]-
a-CD, we succeeded to get iodinin-loaded nanoformulations with good parameters such as a size of
97.9 nm, 62% encapsulation efficiency and efficient control release. The study presents an interesting alternative
to optimizing the water solubility of iodinin by chemical modifications of iodinin.